MATERNAL OBESITY, INFLAMMATION AND EPIGENETIC MODIFICATIONS IN FETAL INTESTINE

母体肥胖、胎儿肠道炎症和表观遗传修饰

• 批准号: 7960353
• 负责人: Meijun Zhu
• 金额: $ 5.35万
• 依托单位: UNIVERSITY OF WYOMING
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2010-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7960353
• 关键词: 3 year old; Age-Years; Allergic; American; Bacteria; Biomedical Research; Child; Computer Retrieval of Information on Scientific Projects Database; Computer Systems Development; Country; Development; Disease; Ensure; Epigenetic Process; Fetal Development; Fetal Gastrointestinal Tract; Fetus; Food Hypersensitivity; Funding; Gastrointestinal tract structure; Grant; Health; Human; Immune response; Immune system; Inflammation; Inflammatory; Institution; Intervention; Intestines; Knowledge; Modeling; Modification; Mucous Membrane; National Health and Nutrition Examination Survey; Nutritional Requirements; Obesity; Pregnancy; Pregnant Women; Quality of life; Research; Research Personnel; Resources; Sheep; Source; Staging; Surveys; Time; United States National Institutes of Health; Wyoming; cytokine; feeding; fetal; improved; pathogen; pregnant

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The obesity rate increased more than 2 fold in recent decades. According to the latest NHANES survey (1999-2002), 29% of non-pregnant women 20-39 years of age are obese. At the same time, food allergy and related mucosal inflammatory diseases in gastrointestinal tract (GI) is also increasing (3.4% of all American have food allergy but more than 5% for children under 3 years old). Major steps of mucosal immune system development are accomplished during the fetal stage. We hypothesize that maternal obesity (MO) induces systemic inflammation in fetal GI tract, which enhances pro-inflammatory cytokine expression in gut mucosa, favoring inflammatory immune response which is associated with GI inflammatory diseases. We will use our well-established obese pregnant sheep model - ewes fed 100% (Con) or 150% of nutrient requirements (OB) to study the effect of MO on mucosal immune system (MIS) development. Due to the similarity of fetal development with the human fetus, pregnant sheep are one of the most powerful and widely used models for fetal development studies that relate to important problems in human pregnancy. MIS is responsible for the defense of tremendous amount of bacteria and opportunistic pathogens in GI tract and their proper development is crucial for lifelong health. Knowledge obtained in this study will provide targets for interventions to ensure proper development of MIS, improving the quality of life for the increasing number of obese people, as well as people suffered by allergic diseases in this country.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 近几十年来，肥胖率提高了2倍以上。根据最新的NHANES调查（1999-2002），20-39岁的非怀孕妇女中有29％肥胖。同时，胃肠道（GI）中的食物过敏和相关的粘膜炎症性疾病也正在增加（3.4％的美国人患有食物过敏，但3岁以下儿童的食物过敏）。在胎儿阶段完成了粘膜免疫系统发育的主要步骤。我们假设孕产妇肥胖症（MO）会诱导胎儿胃肠道的全身性炎症，从而增强了肠粘膜促炎性细胞因子的表达，有利于与胃肠道炎性疾病有关的炎性免疫反应。我们将使用良好的肥胖怀孕绵羊模型 - 母羊喂养100％（con）或150％的营养需求（OB）来研究MO对粘膜免疫系统（MIS）发育的影响。由于胎儿发育与人类胎儿的相似性，怀孕的绵羊是胎儿发育研究最强大，最广泛使用的模型之一，与人类怀孕的重要问题有关。 MIS负责捍卫胃肠道中大量细菌和机会性病原体，其适当发育对于终身健康至关重要。在这项研究中获得的知识将为您提供干预措施的目标，以确保MIS的适当发展，改善肥胖人数越来越多的生活质量，以及该国过敏性疾病所遭受的遭受的人。