Anxiety Vulnerability and Smoking Cessation

描述(由申请人提供)：本提案的主要目标如下：1.为了检验这样一种假设，即吸烟者的焦虑敏感度(AS)比焦虑敏感度(AS)低的吸烟者在自我指导戒烟尝试中表现出的成功率较低，其指标为：(1.a.1)首次戒烟时间较短；(1.a.2)较低点--戒烟后一周、两周、四周和12周的戒烟率。1.B.为了验证AS与再次吸烟/再次吸烟之间的联系是由特定的情绪和基于吸烟的过程介导的假设，包括：(1.b.1)戒烟尝试期间更高水平的负面情绪强度；(1.b.2)在戒烟尝试期间更高水平的尼古丁戒断症状强度。公共卫生相关性：本提案填补了吸烟精神病学文献中在临床上和理论上所需的空白，正如最近NIMH吸烟精神脆弱性报告(Ziedonis等人，正在出版中)所支持的那样。事实上，拟议的研究结果将直接为AS吸烟模型提供信息，并更广泛地用作说明特定的与焦虑相关的过程如何有助于维持吸烟行为。这项拟议的调查对一项旨在了解吸烟失误和复发机制的研究计划来说，是一项具有临床意义和创新的测试。

DESCRIPTION (provided by applicant): The primary objectives of the current proposal are as follows: 1.a. To test the hypothesis that smokers characterized by higher compared to lower Anxiety Sensitivity (AS) will demonstrate less success in a self-guided cessation attempt, as indexed by: (1.a.1) Shorter time to first smoking lapse; (1.a.2) Lower point-prevalence abstinence at one, two, four, and 12 weeks post-quit date. 1.b. To test the hypothesis that the association between AS and lapse/relapse to smoking is mediated by the specified emotion and smoking-based processes, including: (1.b.1) Greater levels of negative affect intensity during the cessation attempt; (1.b.2) Greater levels of nicotine withdrawal symptom intensity during the cessation attempt. PUBLIC HEALTH RELEVANCE: The present proposal fills a needed clinically- and theoretically-relevant gap in the smoking- psychiatric literature, as recently espoused by the current NIMH smoking-psychiatric vulnerability report (Ziedonis et al., in press). Indeed, results of the proposed study will directly inform AS-smoking models, and serve more generally as an illustration of how specific anxiety-related processes serve to maintain smoking behavior. The proposed investigation represents a clinically significant and innovative test for a program of research aimed at understanding the mechanisms underlying smoking lapse and relapse.