Optimising benefits and minimising potential harms of obesity treatments

这项工作旨在为全球超过21亿的超重或肥胖人群找到安全有效的肥胖治疗方法。严格限制能量的饮食是目前最有效的饮食肥胖治疗方法，但由于担心潜在的危害，这些方法没有得到充分利用。这项工作将研究间歇性地而不是连续地使用严格的饮食，作为一种提高长期体重/脂肪减少的好处，同时减少潜在有害影响的手段。

This work aims to find safe and more effective obesity treatments for the over 2.1 billion people worldwide with overweight or obesity. Severely energy restricted diets are currently the most effective dietary obesity treatment, but these are underutilized due to concerns about potential harms. This work will investigate using severe diets intermittently rather than continuously, as a means of enhancing their benefits of long-term weight/fat loss while also reducing potential harmful effects.