A History of Cell Biology from the Perspective of the Signal Hypothesis

信号假说视角下的细胞生物学史

• 批准号: 7921463
• 负责人: KARL S MATLIN
• 金额: $ 7.85万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7921463
• 关键词: Binding; Biochemical; Biochemistry; Biological; Biological Phenomena; Biological Sciences; Biology; Books; Cell-Free System; Cells; Cellular biology; Centrifugation; Cytology; Development; Discipline; Drug Formulations; Electron Microscopy; Epigenetic Process; Event; Foundations; Funding; Genetic; Genetic Engineering; Genomics; In Vitro; Interview; Knowledge; Life; Mainstreaming; Membrane; Modeling; Molecular; Molecular Analysis; Molecular Biology; One-Step dentin bonding system; Organism; Participant; Pathway interactions; Phase; Philosophy; Plant Roots; Positioning Attribute; Preparation; Protein Secretion; Protein translocation; Proteins; Qualifying; Recording of previous events; Relative (related person); Reporting; Request for Applications; Research; Science; Signal Transduction; Staging; System; Time; Universities; Work; World War II; Writing; programs; reconstitution; repository; research study; secretory protein

DESCRIPTION (provided by application): The history and philosophy of cell biology is largely unexplored in comparison to that of molecular biology. Of the two recent books that have examined the origins of cell biology, Bechtel's Discovering Cell Mechanisms (2006) only followed advances prior to 1970 while Rasmussen's Picture Control (1997) limited itself to a description of the development of biological electron microscopy until 1960. This application requests funds to write a history of cell biology focused on the research that elucidated the secretory pathway, primarily conducted at the Rockefeller University. In particular, the book will use the year 1975 as a pivot point to examine and describe the development of the signal hypothesis by G¿nter Blobel and David Sabatini prior to 1975, its demonstration by Blobel in 1975, and his extension and elaboration of it into a model of protein topogenesis in subsequent years (Aim 1). The book will, in addition, explore the philosophical relationships between molecular biology and cell biology, and will argue that, of the two disciplines, cell biology is more capable of explaining biological phenomena than the extreme reductionist research program of molecular biology (Aim 2)

描述（由应用程序提供）： 与分子生物学相比，细胞生物学的历史和哲学在很大程度上是未探索的。在最近的两本研究细胞生物学起源的书中，Bechtel的《发现细胞机制》（2006年）仅遵循了1970年之前的进展，而Rasmussen的《图像控制》（1997年）仅限于描述1960年之前生物电子显微镜的发展。该申请要求资金撰写细胞生物学的历史，重点是阐明 分泌途径，主要在洛克菲勒大学进行。特别是，这本书将使用1975年作为一个支点，以检查和描述信号假说的发展由Günter Blobel和大卫Sabatini在1975年之前，它的演示由Blobel在1975年，和他的扩展和阐述它成为一个模型的蛋白质拓扑发生在随后的几年（目的1）。此外，这本书还将探讨分子生物学和细胞生物学之间的哲学关系，并认为，在这两个学科中，细胞生物学比分子生物学的极端还原主义研究计划更能解释生物现象。