A History of Cell Biology from the Perspective of the Signal Hypothesis

描述(由应用程序提供)： 与分子生物学相比，细胞生物学的历史和哲学在很大程度上是未被探索的。在最近研究细胞生物学起源的两本书中，贝克特尔的《发现细胞机制》(2006)只遵循1970年之前的进展，而拉斯穆森的《图片控制》(1997)仅限于描述直到1960年的生物电子显微镜的发展。这项申请申请资金，以撰写细胞生物学的历史，重点是阐明分泌途径的研究，主要是在洛克菲勒大学进行的。特别是，该书将以1975年为支点，检查和描述1975年之前G？nter Blobel和David Sabatini对信号假说的发展，Blobel在1975年的演示，以及他在随后几年将其扩展和详细阐述为蛋白质拓扑学模型(目标1)。此外，这本书还将探讨分子生物学和细胞生物学之间的哲学关系，并将争辩说，在这两个学科中，细胞生物学比极端简化论的分子生物学研究计划更有能力解释生物现象(目标2)。

DESCRIPTION (provided by application): The history and philosophy of cell biology is largely unexplored in comparison to that of molecular biology. Of the two recent books that have examined the origins of cell biology, Bechtel's Discovering Cell Mechanisms (2006) only followed advances prior to 1970 while Rasmussen's Picture Control (1997) limited itself to a description of the development of biological electron microscopy until 1960. This application requests funds to write a history of cell biology focused on the research that elucidated the secretory pathway, primarily conducted at the Rockefeller University. In particular, the book will use the year 1975 as a pivot point to examine and describe the development of the signal hypothesis by G¿nter Blobel and David Sabatini prior to 1975, its demonstration by Blobel in 1975, and his extension and elaboration of it into a model of protein topogenesis in subsequent years (Aim 1). The book will, in addition, explore the philosophical relationships between molecular biology and cell biology, and will argue that, of the two disciplines, cell biology is more capable of explaining biological phenomena than the extreme reductionist research program of molecular biology (Aim 2)