SEROLOGICAL MARKERS OF PERIODONTAL DISEASE AND PANCREATIC CANCER RISK

牙周疾病和胰腺癌风险的血清学标志物

• 批准号: 7790045
• 负责人: JACQUES G. IZARD
• 金额: $ 24.72万
• 依托单位: BROWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-04-01 至 2012-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7790045
• 关键词: Actinobacillus actinomycetemcomitans; Address; Anaerobic Bacteria; Antibodies; Area; Bacteria; Biological; Biological Assay; Biological Markers; Blood; Blood specimen; Boston; Budgets; Cancer Etiology; Cancer Patient; Cancer and Nutrition; Caring; Cessation of life; Chronic; Cohort Studies; Data; Dental; Development; Diagnosis; Disease; Disease Progression; Early Diagnosis; Epidemiologic Studies; Epidemiology; Etiology; European; Forsythia; General Population; Genetic Predisposition to Disease; Gingiva; Head; Health Professional; Health Status; Immune; Immune response; Immunoglobulins; Incidence; Infection; Inflammatory; Inherited; Institutes; Institution; Investigation; Laboratories; Lead; Light; Link; London; Malignant Neoplasms; Malignant neoplasm of pancreas; Measurement; Measures; Nature; Obesity; Oral; Oral health; Organism; Pancreatitis; Patient Self-Report; Patients; Periodontal Diseases; Periodontal Infection; Periodontitis; Plasma; Porphyromonas gingivalis; Prevention; Prevention Research; Public Health; Publications; Reaction; Recommendation; Research; Resources; Risk Factors; Role; Sampling; Seminal; Smoker; Smoking Status; Stroke; Syndrome; Testing; Tobacco smoke; Tooth Loss; Translating; Treponema denticola; base; cancer diagnosis; cancer risk; case control; chronic pancreatitis; cigarette smoking; cohort; college; cost; design; high risk; indexing; insight; member; mortality; oral microbiome; oral pathogen; outcome forecast; pathogen; prospective; public health relevance; research study; response; serological marker

DESCRIPTION (provided by applicant): Pancreas cancer is the fourth leading cause of cancer-related death and is highly lethal; 95% of patients with this cancer die within 5 years of initial diagnosis. Understanding the etiology of pancreatic cancer is critical to implement steps towards prevention and may concurrently provide insights on how to treat and detect this malignancy. Little is known about the causes of pancreatic cancer; tobacco smoke, chronic pancreatitis, familial syndromes, and other suspected risk factors can only explain 25-30% of all pancreatic cancer cases. Several studies support an association between periodontitis and pancreatic cancer risk; in a recent publication, this association was observed among never smokers in a large prospective cohort of health professionals. The implications for this association, if confirmed, are substantial and will include the need for more efforts towards understanding the underlying mechanisms. As periodontal disease is difficult to measure in epidemiologic settings, our proposal to use antibodies to periodontal organisms should shed light on the plausibility of this association in an efficient and rapid fashion. Furthermore, our approach will avoid concerns of measurement error related to use of self-report of periodontal disease or use of retrospective assessment of periodontal disease in a case-control setting. Our study will be able to directly address the question of whether periodontal infection was present before the cancer onset as all bloods were collected pre-diagnostically. For this study, we propose to measurement antibodies to four common periodontal bacterial pathogens and to anaerobic bacteria that have been linked to pancreatitis and are also part of the oral microbiome. The association between the antibodies tested and pancreatic cancer will be examined using 468 pancreatic cancer cases and matched controls from the European Prospective Investigation into Cancer (EPIC) cohort study. Detailed data on risk factors of pancreatic cancer are available in this study and will be included in the analysis to control for potential confounding. This study should provide valuable data to further evaluate the potential role of periodontal disease in the etiology of pancreatic cancer and may provide a new area of research for the prevention of this highly fatal cancer. PUBLIC HEALTH RELEVANCE: This study will provide valuable data on periodontal disease and pancreatic cancer risk and may open a new area of research for this highly fatal cancer. In addition, findings from this study could lead to insights into the mechanism of pancreatic cancer which may translate into prevention recommendations or treatments that could reduce the incidence and mortality from this highly lethal malignancy.

描述（由申请人提供）：胰腺癌是癌症相关死亡的第四大原因，并且具有高度致命性； 95% 的这种癌症患者在初次诊断后 5 年内死亡。了解胰腺癌的病因对于实施预防措施至关重要，同时可能为如何治疗和检测这种恶性肿瘤提供见解。人们对胰腺癌的病因知之甚少。烟草烟雾、慢性胰腺炎、家族综合症和其他可疑的危险因素只能解释所有胰腺癌病例的 25-30%。多项研究支持牙周炎与胰腺癌风险之间的关联；在最近的一份出版物中，在一大群前瞻性卫生专业人员中从不吸烟者中观察到了这种关联。如果这种关联得到证实，其影响将是巨大的，并且将包括需要付出更多努力来理解根本机制。由于牙周病在流行病学环境中很难测量，我们建议使用牙周生物抗体，应该能够以有效和快速的方式阐明这种关联的合理性。此外，我们的方法将避免与使用牙周病自我报告或在病例对照环境中使用牙周病回顾性评估相关的测量误差的担忧。我们的研究将能够直接解决癌症发病前是否存在牙周感染的问题，因为所有血液都是在诊断前收集的。在这项研究中，我们建议测量四种常见牙周细菌病原体和与胰腺炎相关且也是口腔微生物组一部分的厌氧菌的抗体。将使用来自欧洲癌症前瞻性调查 (EPIC) 队列研究的 468 例胰腺癌病例和匹配对照来检查所测试的抗体与胰腺癌之间的关联。本研究提供了有关胰腺癌危险因素的详细数据，并将纳入分析中以控制潜在的混杂因素。这项研究应该为进一步评估牙周病在胰腺癌病因学中的潜在作用提供有价值的数据，并可能为预防这种高度致命的癌症提供新的研究领域。 公共健康相关性：这项研究将提供有关牙周病和胰腺癌风险的宝贵数据，并可能为这种高度致命的癌症开辟一个新的研究领域。此外，这项研究的结果可能有助于深入了解胰腺癌的机制，这可能转化为预防建议或治疗方法，从而降低这种高度致命的恶性肿瘤的发病率和死亡率。