Polymer-Based Approaches for Exploring Polymorph Space
基于聚合物的多晶型空间探索方法
基本信息
- 批准号:7933382
- 负责人:
- 金额:$ 3万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2009
- 资助国家:美国
- 起止时间:2009-09-30 至 2010-05-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAzithromycinBehaviorBioavailableBiological AvailabilityCharacteristicsChemicalsComputer SimulationConstitutionControlled StudyCrystallizationDevelopmentDrug Delivery SystemsDrug FormulationsEffectivenessEquilibriumEventFlutamideFutureGanciclovirGoalsGrowthIsomerismItraconazoleKetoconazoleKineticsLeadLibrariesMethodologyMethodsOutcomePharmaceutical PreparationsPharmacologic SubstancePhasePolymersProductionPropertyResearchResearch PersonnelRoleSolidSolubilitySpectrum AnalysisStagingStructureSurfaceTechniquesTestingTherapeutic Agentsaqueousbasedehydroepiandrosteronedensitydesigndosagefunctional groupmethod developmentmolecular recognitionneutrophilnovelprogramspublic health relevancesolid state
项目摘要
DESCRIPTION (provided by applicant): The role of solid-state form in determining the properties of Pharmaceuticals is a critical issue in drug delivery. The ability of a solid to exist as more than one polymorph, supramolecular isomers that differ only in packing and not constitution, creates a situation where each crystal form may have different bioavailability and stability. Only by discovering the presence of new polymorphs and their unique properties can the most efficacious form for a solid dosage be found. This proposal outlines a method for studying and controlling this important aspect of crystal growth. Specific Aim 1-Develop a general methodology for producing new polymorphs. We will create libraries of polymers that can heteronucleate crystallization of solids. It is proposed that varying the functional groups on the surface of the polymer and the orientation and density of these functional groups will allow kinetic access to new polymorphs by creating novel heteronucleation events. Specific Aim 2-lnvestigate the relationship between polymer structure and crystal polymorph obtained. Though it has been established that the majority of crystallizations on a macroscopic scale proceed through heteronucleation events, there is little information about the influence of the substrate on crystallization events. Using the approach developed in Specific Aim 1 to find polymers that create novel polymorphs, we will determine which characteristics are important for controlling polymorph production. Specific Aim 3-Determine the properties of novel polymorphs. With the ultimate goal of finding more efficacious forms of existing and new Pharmaceuticals, the determination of several key properties of the new polymorphs will be undertaken including stability, equilibrium solubility and dissolution rate.
brief description of public health relevance: The effectiveness of a drug substance is not solely related to its chemical composition but also to how the molecules arrange in the solid. This proposal offers a method for optimizing this important aspect of drug delivery and will lead to the development of more effective forms of current and future therapeutic agents.
描述(由申请人提供):固态形式在确定药物性质中的作用是药物递送中的关键问题。固体作为多于一种多晶型物(仅在包装而非构成上不同的超分子异构体)存在的能力产生了其中每种晶体形式可能具有不同的生物利用度和稳定性的情况。只有通过发现新的多晶型物的存在及其独特的性质,才能找到最有效的固体剂型。该提案概述了研究和控制晶体生长这一重要方面的方法。具体目标1-开发生产新多晶型物的通用方法。我们将创建聚合物库,可以异核结晶的固体。有人提出,改变聚合物表面上的官能团和这些官能团的取向和密度将允许通过创建新的异核化事件动力学访问新的多晶型物。具体目标2-研究聚合物结构和获得的晶体多晶型物之间的关系。虽然它已被确定,在宏观尺度上的大多数结晶进行通过异核化事件,有很少的信息对结晶事件的基板的影响。使用特定目标1中开发的方法来寻找产生新型多晶型物的聚合物,我们将确定哪些特性对于控制多晶型物生产是重要的。具体目标3-确定新的多晶型物的性质。最终目标是找到现有和新药物的更有效形式,将确定新多晶型物的几个关键性质,包括稳定性、平衡溶解度和溶出速率。
与公共卫生相关的简要说明:药物的有效性不仅与其化学成分有关,还与分子在固体中的排列方式有关。该提案提供了一种优化药物递送这一重要方面的方法,并将导致开发当前和未来治疗剂的更有效形式。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
数据更新时间:{{ journalArticles.updateTime }}
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Adam Jay Matzger其他文献
Adam Jay Matzger的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Adam Jay Matzger', 18)}}的其他基金
Improving drug bioavailability through solid form discovery
通过固体形式发现提高药物生物利用度
- 批准号:
8919408 - 财政年份:2013
- 资助金额:
$ 3万 - 项目类别:
Improving drug bioavailability through solid form discovery
通过固体形式发现提高药物生物利用度
- 批准号:
8737297 - 财政年份:2013
- 资助金额:
$ 3万 - 项目类别:
Improving drug bioavailability through solid form discovery
通过固体形式发现提高药物生物利用度
- 批准号:
8482952 - 财政年份:2013
- 资助金额:
$ 3万 - 项目类别:
Polymer-Based Approaches for Exploring Polymorph Space
基于聚合物的多晶型空间探索方法
- 批准号:
7426899 - 财政年份:2006
- 资助金额:
$ 3万 - 项目类别:
Polymer-Based Approaches for Exploring Polymorph Space
基于聚合物的多晶型空间探索方法
- 批准号:
7625154 - 财政年份:2006
- 资助金额:
$ 3万 - 项目类别:
Polymer-Based Approaches for Exploring Polymorph Space
基于聚合物的多晶型空间探索方法
- 批准号:
7251428 - 财政年份:2006
- 资助金额:
$ 3万 - 项目类别:
Polymer-Based Approaches for Exploring Polymorph Space
基于聚合物的多晶型空间探索方法
- 批准号:
7847428 - 财政年份:2006
- 资助金额:
$ 3万 - 项目类别:
Polymer-Based Approaches for Exploring Polymorph Space
基于聚合物的多晶型空间探索方法
- 批准号:
7426730 - 财政年份:2006
- 资助金额:
$ 3万 - 项目类别:
Polymer-Based Approaches for Exploring Polymorph Space
基于聚合物的多晶型空间探索方法
- 批准号:
7144245 - 财政年份:2006
- 资助金额:
$ 3万 - 项目类别:
相似海外基金
Single dose azithromycin to prevent cholera in children
单剂量阿奇霉素预防儿童霍乱
- 批准号:
10632107 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
Repurposing Azithromycin for premature brain injury
重新利用阿奇霉素治疗过早脑损伤
- 批准号:
10375396 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
Single dose azithromycin to prevent cholera in children
单剂量阿奇霉素预防儿童霍乱
- 批准号:
10462780 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
A Phase III Randomized Controlled Trial of Azithromycin for RSV-induced Respiratory Failure in Children
阿奇霉素治疗 RSV 引起的儿童呼吸衰竭的 III 期随机对照试验
- 批准号:
10670177 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
Repurposing Azithromycin for premature brain injury
重新利用阿奇霉素治疗过早脑损伤
- 批准号:
10580029 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
A Phase III Randomized Controlled Trial of Azithromycin for RSV-induced Respiratory Failure in Children
阿奇霉素治疗 RSV 引起的儿童呼吸衰竭的 III 期随机对照试验
- 批准号:
10458679 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
Single dose azithromycin to prevent cholera in children
单剂量阿奇霉素预防儿童霍乱
- 批准号:
10297046 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
'Azithromycin before Birth'- Single dose azithromycin shortly before birth to reduce infection in Aboriginal mothers and babies: a randomised controlled trial.
“出生前服用阿奇霉素”——在出生前不久服用单剂量阿奇霉素以减少原住民母亲和婴儿的感染:一项随机对照试验。
- 批准号:
nhmrc : 2001751 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
Clinical Trials and Cohort Studies Grants
A Phase III Randomized Controlled Trial of Azithromycin for RSV-induced Respiratory Failure in Children
阿奇霉素治疗 RSV 引起的儿童呼吸衰竭的 III 期随机对照试验
- 批准号:
10272639 - 财政年份:2021
- 资助金额:
$ 3万 - 项目类别:
1/2: AZithromycin Therapy in Preschoolers with a Severe Wheezing Episode Diagnosed at the Emergency Department (AZ-SWED)
1/2:阿奇霉素治疗在急诊科诊断出严重喘息发作的学龄前儿童 (AZ-SWED)
- 批准号:
10274820 - 财政年份:2020
- 资助金额:
$ 3万 - 项目类别: