Micronutrient intervention to reduce noise-induced hearing loss

微量营养素干预可减少噪音引起的听力损失

• 批准号: 7922970
• 负责人: Josef Mayer Miller
• 金额: $ 29.75万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-17 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7922970
• 关键词: Address; Adverse effects; Adverse event; Animal Welfare; Animals; Antioxidants; Arts; Bibliography; Clinical; Clinical Trials; Combined Modality Therapy; Communication impairment; Consumption; Country; Critiques; Data; Doctor of Philosophy; Dose; Drug Formulations; Engineering; Environment; Environmental Impact; Equipment; Evaluation; Faculty; Florida; Funding; Hearing; Human; IACUC; Individual; International; Intervention; Ischemia; Literature; Measurement; Medical; Medical center; Micronutrients; Monitor; Music; N-Methyl-D-Aspartate Receptors; NMDA receptor antagonist; Noise; Noise-Induced Hearing Loss; Otolaryngology; Pharmaceutical Preparations; Play; Population; Positioning Attribute; Principal Investigator; Procedures; Published Comment; Publishing; Recording of previous events; Reflex action; Research; Research Design; Research Ethics Committees; Research Personnel; Resources; Role; Site; Spain; Speech; Supervision; Sweden; Testing; Toxic effect; Universities; Vasodilation; Vertebrates; Work; abstracting; acoustic reflex; animal data; base; clinical effect; cost; design; expectation; expiration; hearing impairment; human subject; interest; musician; novel; professor; programs; research clinical testing; response; tensor tympani muscle

Noise-induced hearing loss (NIHL) is a significant clinical, social, and economic issue; resolving this important health issue is central to the mission of the NIDCD. Our long-term strategic program of "bedside to laboratory bench to bedside" directly leads to the current proposal to translate an intervention from "bench to bedside". Ten years of NIDCD funding for studies in animals have allowed us to identify mechanisms contributing to NIHL, including direct mechanical trauma, free radicals formed in association with metabolic stress, and reduced blood flow. We have now identified a combination of micronutrients (antioxidants and other agents) as highly effective in preventing NIHL in animals. This treatment significantly attenuates sensory cell death in the inner ear and corresponding threshold deficits. The proposed studies, conducted by an international team including basic scientists, otolaryngologists, and audiologists, will demonstrate efficacy of this therapeutic intervention in humans during carefully-controlled clinical trials with real-world noise insults. Specific Aim 1 will verify therapeutic efficacy with real-world noise insults that induce temporary threshold shifts; these studies will focus on loud music under laboratory conditions, and military urban warfare training exercises. Specific Aim 2 will verify therapeutic efficacy in humans exposed to occupational noise on a daily basis, including aircraft noise experienced by pilots and ground crew, and machine noise experienced by cutlery workers. Availability of an effective treatment will reduce development of hearing loss in at-risk human populations, thereby improving quality of life for millions and decreasing healthcare costs for individuals, businesses, and government agencies. Funds are therefore requested to initiate a series of Phase II clinical trials to demonstrate for the first time the effectiveness of this intervention in man. This program is intended to be the first translational research step to eliminate NIHL in the 21st century. Noise-induced hearing loss is an important medical, social, and economic issue. We have identified a treatment that reduces inner ear cell death and hearing loss in animals. These studies will demonstrate efficacy of this treatment in humans. This prevention will improve quality of life for the millions exposed to noise, and decrease healthcare costs for individuals, businesses, and government agencies.

噪声性听力损失（NIHL）是一个重要的临床、社会和经济问题;解决这一重要的健康问题是NIDCD的核心使命。我们的长期战略计划“床边到实验室工作台到床边”直接导致了目前的建议，将干预措施从“工作台到床边”。NIDCD对动物研究的十年资助使我们能够确定导致NIHL的机制，包括直接机械创伤，与代谢应激相关的自由基形成以及血流量减少。我们现在已经确定了一种微量营养素（抗氧化剂和其他药物）的组合，在预防动物NIHL方面非常有效。这种治疗显著减弱了内耳中的感觉细胞死亡和相应的阈值缺陷。由包括基础科学家，耳鼻喉科医生和听力学家在内的国际团队进行的拟议研究将在对现实世界噪声损伤进行仔细控制的临床试验期间证明这种治疗干预对人类的有效性。具体目标1将验证治疗效果与现实世界的噪音侮辱，诱导暂时的阈值偏移;这些研究将集中在响亮的音乐在实验室条件下，和军事城市作战训练演习。具体目标2将验证每天暴露于职业噪音的人类的治疗效果，包括飞行员和地勤人员经历的飞机噪音，以及餐具工人经历的机器噪音。有效治疗的可用性将减少高危人群听力损失的发展，从而提高数百万人的生活质量，降低个人，企业和政府机构的医疗保健成本。因此，要求资金启动一系列的第二阶段临床试验，以证明首次在man. This计划的干预的有效性，旨在成为第一个转化的研究步骤，以消除NIHL在21世纪。噪声性听力损失是一个重要的医学、社会和经济问题。我们已经确定了一种治疗方法，可以减少动物内耳细胞死亡和听力损失。这些研究将证明这种治疗在人类中的疗效。这种预防措施将改善数百万暴露于噪音的人的生活质量，并降低个人，企业和政府机构的医疗保健成本。