VISUALIZATION SOFTWARE FOR ELECTRON MICROSCOPY
电子显微镜可视化软件
基本信息
- 批准号:8170522
- 负责人:
- 金额:$ 1.79万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-07-01 至 2011-06-30
- 项目状态:已结题
- 来源:
- 关键词:3-DimensionalChimera organismColorComputer Retrieval of Information on Scientific Projects DatabaseComputer softwareCrystallographyDatabasesElectron MicroscopyFilamentFundingGrantInstitutionLifeLigand BindingMapsMethodsMicrotubulesModelingMolecular MachinesMolecular ModelsMotorMuscleOrganismProteinsResearchResearch PersonnelResolutionResourcesRibosomesSliceSoftware ToolsSourceStructureSurfaceSystemUnited States National Institutes of HealthVirusVisualization softwareWorkdensitymacromoleculemolecular assembly/self assemblymolecular modelingsoftware development
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
We are developing software for interactively analyzing 3-dimensional
density maps obtained by electron microscopy (EM). The analysis aims
to determine structures and inner workings of molecular machines such
as viruses, ribosomes, microtubules and motors, muscle filaments, and
dozens of others systems that are targets of current research. It is
believed that most proteins in living organisms are parts of large
molecular assemblies. Advances in experimental methods in the past
several years have greatly accelerated research on these systems. The
primary database of EM density maps
(http://www.ebi.ac.uk/msd-srv/emsearch/index.html) was founded in 2002
and now (2010) has 773 entries. Software for deducing structures from
these maps is being actively developed by many labs.
Our software displays contour surfaces of density maps. Maps from
electron microscopy have resolutions in the 5 - 100 Angstrom range
which is too coarse to see atomic detail. Analysis involves fitting
known atomic structures from crystallography into the maps,
identifying structures in maps corresponding to unidentified proteins,
and comparing maps of the same system under different experimental
conditions to deduce conformational changes or binding of ligands or
specific macromolecules. Our software tools, which are part of the
UCSF Chimera molecular modeling package, support fitting, carving out
density regions, coloring maps, and building coarse models in maps.
In the past we have added the ability to slice maps along an
arbitrarily oriented and movable plane displaying density values on
the cut surface.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
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会议论文数量(0)
专利数量(0)
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THOMAS GODDARD其他文献
THOMAS GODDARD的其他文献
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{{ truncateString('THOMAS GODDARD', 18)}}的其他基金
MODELING USING SMALL-ANGLE X-RAY SCATTERING DATA
使用小角度 X 射线散射数据进行建模
- 批准号:
8363623 - 财政年份:2011
- 资助金额:
$ 1.79万 - 项目类别:
MULTI-SCALE VISUALIZATION OF LARGE MOLECULAR COMPLEXES
大分子复合物的多尺度可视化
- 批准号:
8363584 - 财政年份:2011
- 资助金额:
$ 1.79万 - 项目类别:
MODELING USING SMALL-ANGLE X-RAY SCATTERING DATA
使用小角度 X 射线散射数据进行建模
- 批准号:
8170563 - 财政年份:2010
- 资助金额:
$ 1.79万 - 项目类别:














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