POLYMER/NANOROD COMPOSITES FOR CONTROLLED DRUG DELIVERY

这个子项目是许多研究子项目中利用 资源由NIH/NCRR资助的中心拨款提供。子项目和 调查员(PI)可能从NIH的另一个来源获得了主要资金， 并因此可以在其他清晰的条目中表示。列出的机构是 该中心不一定是调查人员的机构。 该项目的目标是开发一种复合材料(可生物降解的聚合物和纳米棒)，用于控制治疗分子的输送。这种聚合物的设计使玻璃化转变温度比体温高出约5摄氏度，因此当样品暴露在近红外光(~800 nm)和吸收纳米棒的热量下时，样品从玻璃状聚合物转变为橡胶聚合物。据推测，这种过渡性变化将导致分子通过聚合物扩散的变化，并将同时释放到周围组织。我们已经进行了所有关于聚合物机械转变、纳米棒制造的工作，下一步是说明样品在光照下发热。如果显示了这一点，则将通过将样品暴露在光中来测量分子的释放。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project is to develop a composite (biodegradable polymer and nanorods) for controlled delivery of therapeutic molecules. The polymer is designed so that the glass transition temperature is ~ 5 degrees C above body temperature, so that when the sample is exposed to NIR light (~ 800 nm) and the absorbing nanorods heat, the sample goes from a glassy to rubbery polymer. It is hypothesized that this transition change will lead to changes in molecule diffusion through the polymer and will simultaneously be released to the surrounding tissue. We have conducted all conducted all work on the polymer mechanical transitions, nanorod fabrication, and the next step is to illustrate that the samples heat upon light exposure. If that is shown, the release of a molecule will be measured with exposure of the sample to light.