POLYMER/NANOROD COMPOSITES FOR CONTROLLED DRUG DELIVERY

用于控制药物输送的聚合物/纳米棒复合材料

• 批准号: 8169550
• 负责人: Jason A Burdick
• 金额: $ 0.42万
• 依托单位: UNIVERSITY OF PENNSYLVANIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2011-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8169550
• 关键词: Body Temperature; Computer Retrieval of Information on Scientific Projects Database; Diffusion; Drug Delivery Systems; Funding; Glass; Grant; Heating; Institution; Lead; Light; Measures; Mechanics; Polymers; Research; Research Personnel; Resources; Sampling; Source; Therapeutic; Tissues; Transition Temperature; United States National Institutes of Health; Work; biodegradable polymer; design; nanorod

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project is to develop a composite (biodegradable polymer and nanorods) for controlled delivery of therapeutic molecules. The polymer is designed so that the glass transition temperature is ~ 5 degrees C above body temperature, so that when the sample is exposed to NIR light (~ 800 nm) and the absorbing nanorods heat, the sample goes from a glassy to rubbery polymer. It is hypothesized that this transition change will lead to changes in molecule diffusion through the polymer and will simultaneously be released to the surrounding tissue. We have conducted all conducted all work on the polymer mechanical transitions, nanorod fabrication, and the next step is to illustrate that the samples heat upon light exposure. If that is shown, the release of a molecule will be measured with exposure of the sample to light.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 该项目的目的是开发一种复合材料（可生物降解的聚合物和纳米棒）来控制治疗分子的递送。设计聚合物的设计使玻璃过渡温度高于体温高约5度，因此，当样品暴露于NIR光（〜800 nm）和吸收的纳米棒热时，样品从玻璃状聚合物到橡胶聚合物。假设这种过渡变化将导致分子扩散通过聚合物的变化，并同时释放到周围的组织中。我们已经进行了所有关于聚合物机械跃迁，纳米棒制造的工作，下一步是说明样品在暴露时会加热。如果显示的话，将通过样品暴露在光线下测量分子的释放。