POLYMER/NANOROD COMPOSITES FOR CONTROLLED DRUG DELIVERY

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。列出的机构是 研究中心，而研究中心不一定是研究者所在的机构。 该项目的目标是开发一种复合材料（可生物降解的聚合物和纳米棒），用于控制治疗分子的递送。该聚合物的玻璃化转变温度比体温高约5摄氏度，因此当样品暴露于近红外光（约800 nm）和吸收纳米棒热量时，样品从玻璃态变成橡胶状聚合物。据推测，这种转变变化将导致分子扩散通过聚合物的变化，并将同时释放到周围组织。我们已经进行了所有关于聚合物机械转变、纳米棒制造的工作，下一步是说明样品在光照下会发热。如果显示出这一点，则将通过将样品暴露于光来测量分子的释放。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. The objective of this project is to develop a composite (biodegradable polymer and nanorods) for controlled delivery of therapeutic molecules. The polymer is designed so that the glass transition temperature is ~ 5 degrees C above body temperature, so that when the sample is exposed to NIR light (~ 800 nm) and the absorbing nanorods heat, the sample goes from a glassy to rubbery polymer. It is hypothesized that this transition change will lead to changes in molecule diffusion through the polymer and will simultaneously be released to the surrounding tissue. We have conducted all conducted all work on the polymer mechanical transitions, nanorod fabrication, and the next step is to illustrate that the samples heat upon light exposure. If that is shown, the release of a molecule will be measured with exposure of the sample to light.