MESA

台面

• 批准号: 8065594
• 负责人: KAROL WATSON
• 金额: $ 3.95万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-01-15 至 2015-08-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8065594
• 关键词: Abdomen; Ancillary Study; Ankle; Area; Atherosclerosis; Behavioral; Biological; California; Cardiac; Cardiovascular Diseases; Characteristics; Clinical; Contracts; Coronary Arteriosclerosis; Data; Data Set; Diabetic Angiopathies; Diabetic Retinopathy; Disease; Ethnic Origin; Event; Eye; Family; Funding; Fundus photography; Genetic; Health Status; Laboratories; Los Angeles; Macular degeneration; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mentors; Myocardial; Nutritional; Participant; Pathology; Pharmaceutical Preparations; Phenotype; Photography; Policies; Population Heterogeneity; Process; Recruitment Activity; Research; Research Design; Research Personnel; Retinal; Risk Marker; Sampling; Severities; Signs and Symptoms; Systemic disease; Time; Training; Ultrasonography; United States National Institutes of Health; Universities; Ventricular Function; Visit; Visual; Visual Acuity; Visual impairment; Woman; Work; X-Ray Computed Tomography; aged; base; brachial artery; cohort; data sharing; design; digital; follow-up; imaging modality; indexing; interest; member; men; population based; psychologic; racial/ethnic difference; radial artery; sex; socioeconomics

The University of California, Los Angeles serves as one of six Field Centers for the Multi-Ethnic Study of Atherosclerosis (MESA), a study of the correlates, predictors and progression of subclinical cardiovascular disease (CVD) (disease detected non-invasively before it has produced clinical signs and symptoms) in a diverse population-based sample of men and women aged 45-84 who had no evidence of clinical CVD at baseline. Six thousand eight hundred and fourteen (6,814) participants were recruited from six Field Centers during 2000-2002 and examined for evidence of subclinical coronary atherosclerosis, using computed tomography, cardiac MRI, carotid ultrasound, flow-mediated brachial artery dilation, radial artery tomometry, ankle-brachial index measurement, and retinal photography and, in subsets, abdominal aortic CT, carotid MRI, cardiac MRI tagging for measures of regional myocardial function; established and putative laboratory risk markers; socioeconomic, psychological, behavioral, nutritional and environmental characteristics; and genetic factors. Selected components were repeated over three subsequent examinations through 2007. The cohort has been followed for clinical events since baseline to ascertain and characterize new clinical events and other changes in health status, including changes in medications. The four scientific objectives for the period 2008 through 2015 are (1) identify factors related to progression of subclinical to clinical CVD; (2) identify predictors of decline in ventricular function; (3) further understanding of the basis for racial/ethnic difference in CVD; and (4) provide a platform for in-depth ancillary studies of CVD and other areas. All surviving and willing members of the MESA cohort will be followed up during the time period and included in an fifth examination during 2010-2012. The study will support in-depth ancillary studies that are funded outside of the current contracts. These studies will be operationally integrated into the main study, and the data will be shared across both types of studies, per current MESA and NIH data-sharing policies. The study's data will be provided to interested investigators through a defined process that encourages maximum data utilization but that protects participant confidentially. The study will also serve as a training ground for junior investigators, who will work with senior investigators and be provided with access to the MESA data set and guidance on conducting research. The MESA-EYE component (refraction and fundus photography) was integrated into the second MESA visit in which 6235 people participated between September 2002 and December 2003. The aims of the ocular component were to document the presence and severity of retinal microvascular changes (as interpreted from digital retinal photos) indicative of macular degeneration and diabetic retinopathy, as well as to describe their interrelationships with cross-sectional and longitudinal measures of microvascular and macrovascular systemic disease as defined clinically, by imaging modality, or by analysis of biological laboratory measures. The visual acuity/objective refraction component was designed to allow us to estimate visual impairment by sex and ethnicity, determine the degree to which visual impairment could be reduced with better refractive correction, and correlate visual findings with retinal pathology. Analyses of various ocular phenotypes, including retinal microvascular disease in MESA Family's ancillary study.

加州大学洛杉矶分校是动脉粥样硬化多种族研究（MESA）的六个领域中心之一，MESA研究亚临床心血管疾病（在产生临床体征和症状之前无创检测到的疾病）的相关性、预测因素和进展，研究对象是年龄在45-84岁、基线无临床心血管疾病证据的不同人群的男性和女性样本。在2000-2002年期间，从六个领域中心招募了6,814名参与者，并使用计算机断层扫描、心脏MRI、颈动脉超声、血流介导的肱动脉扩张、桡动脉断层测量、踝-肱指数测量和视网膜摄影检查亚临床冠状动脉粥样硬化的证据，并在亚组中使用腹主动脉CT、颈动脉MRI、心脏MRI标记来测量局部心肌功能；已建立和假定的实验室风险标记；社会经济、心理、行为、营养和环境特征；还有遗传因素。选定的部分在2007年的三次后续考试中重复进行。从基线开始跟踪该队列的临床事件，以确定和描述新的临床事件和健康状况的其他变化，包括药物的变化。2008年至2015年期间的四个科学目标是：(1)确定与亚临床到临床CVD进展相关的因素；(2)确定心室功能下降的预测因素；(3)进一步了解心血管疾病的种族/民族差异基础；(4)为心血管疾病等领域的深入辅助研究提供平台。MESA队列的所有幸存和自愿成员将在此期间进行随访，并在2010-2012年期间进行第五次检查。该研究将支持在当前合同之外资助的深入辅助研究。这些研究将在操作上整合到主要研究中，数据将根据当前MESA和NIH的数据共享政策在两种类型的研究中共享。研究数据将通过一个明确的流程提供给感兴趣的调查人员，该流程鼓励最大限度地利用数据，但对参与者进行保密。该研究还将作为初级调查人员的培训基地，他们将与高级调查人员一起工作，并获得MESA数据集和开展研究的指导。