HANDLS Scan Substudy: Race, Socioeconomic status, and the Brain

HANDLS 扫描子研究：种族、社会经济地位和大脑

基本信息

批准号：
7931990
负责人：
Shari Waldstein
金额：
$ 59万
依托单位：
UNIVERSITY OF MARYLAND BALTIMORE COUNTY
依托单位国家：
美国
项目类别：
财政年份：
2009
资助国家：
美国
起止时间：
2009-09-15 至 2014-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7931990
关键词：
Address African American Age Alcohols Ancillary Study Anger Anisotropy Baltimore Behavioral Biometry Brain Brain Pathology Cardiovascular system Cerebrovascular Disorders Clinical Research Cognitive Communities Comorbidity Complex Cross-Sectional Studies Data Data Collection Dementia Diet Diffusion Diffusion Magnetic Resonance Imaging Elderly Environmental Risk Factor Epidemiology Equation Future Geriatrics Grant Health Health Services Accessibility Impaired cognition Incidence Intramural Research Program Investigation Knowledge Life Link Literature Longevity Magnetic Resonance Imaging Maryland Measures Mediating Mediation Mediator of activation protein Medical Research Mental Depression Modeling National Institute on Aging Neighborhoods Nephrology Outcome Outcome Measure Participant Pathology Pathway interactions Physical Function Physical activity Population Preventive Intervention Psychological Factors Psychology Race Race Relations Radiology Specialty Recruitment Activity Research Research Personnel Resources Risk Scanning Smoking Social support Socioeconomic Status Spirituality Stress Stroke Structure Testing Vascular Diseases Woman base bioimaging brain volume cardiovascular risk factor cerebral atrophy deprivation design executive function functional decline functional disability gray matter health disparity healthy aging indexing low socioeconomic status member morphometry mortality novel physical conditioning primary outcome psychologic public health relevance racial discrimination resilience sex social socioeconomics vigilance white matter

项目摘要

DESCRIPTION (provided by applicant): Pronounced health disparities associated with race and socioeconomic status (SES) are noted for brain health endpoints including stroke (particularly at younger ages), dementia, brain structure on magnetic resonance imaging (MRI), cognitive decline, and functional disability. Efforts are needed to disentangle respective influences of race and SES on brain health, particularly early and subtle markers of pathology predictive of future stroke and dementia. MRI- assessed measures of gray matter (GM) and white matter (WM) volume and diffusion tensor imaging measures of WM microstructure offer such proven associations. Also critical is identification of multi-level mediators of the relations of race and SES to subtle brain pathology. Biomedical, behavioral, psychological, social and environmental factors have been implicated as potential mediators of the relations of race and SES to many physical health outcomes, but exceedingly little is known about these pathways with respect to brain health. MRI indices of subtle brain pathology may also mediate relations of race and SES to cognitive and physical function. Here we propose an interdisciplinary, ancillary study to the Healthy Aging In Neighborhoods of Diversity Across the Life Span (HANDLS). HANDLS study is a new 20-year epidemiological investigation conducted by the National Institute on Aging's Intramural Research Program focused on understanding health disparities among 4,000 socioeconomically diverse African-Americans (AA) and Whites living in Baltimore, MD. HANDLS is uniquely designed to disentangle the respective relations of race and SES to health outcomes. In HANDLS SCAN we propose to obtain quantitative MRI data from 500 (250 AA, 250 White; ages 30-64) stroke- and dementia-free HANDLS participants with a full range of SES to: (1) Examine race- and SES-related disparities in GM and WM volume, and WM microstructure (2) Examine multi-level mediators - biomedical, behavioral, psychological, social, and environmental - of the relations of race and SES to GM and WM; and (3) Examine whether GM and WM are proximal mediators of the relations of race and SES to cognitive and physical function. Structural equation modeling will be used to construct increasingly complex models to address these interrelated aims. PUBLIC HEALTH RELEVANCE: An understanding of multi-level mediators of the relations of race and SES to early and subtle markers of brain pathology, and the relation of brain pathology to cognitive and physical function, is needed to facilitate appropriate strategies in prevention and intervention critical to the reduction and ultimate elimination of health disparities in stroke, dementia, and cognitive and functional decline.

描述（由申请人提供）：与种族和社会经济状况相关的明显健康差异（SES）对于大脑健康终点（包括中风（尤其是年轻年龄），痴呆症，磁共振成像（MRI）的大脑结构（MRI）（MRI），认知能力下降和功能残疾）的脑部健康终点有所注意到。需要做出努力，以消除种族和SES对大脑健康的影响，尤其是对未来中风和痴呆症的病理学的早期和细微标记。 MRI评估了WM微结构的灰质（GM）和白质（WM）体积（WM）体积（WM）的量度（WM）的测量指标提供了这种验证的关联。同样至关重要的是鉴定种族和SES与细微脑病理关系的多层次介体。生物医学，行为，心理，社会和环境因素已被认为是种族与SE与许多身体健康结果的潜在介体，但对于这些关于大脑健康的途径知之甚少。细微的脑病理学的MRI指数也可能介导种族和SES的关系与认知和身体机能。在这里，我们在整个寿命（Handls）的多样性社区中提出了一项跨学科的辅助研究。 Handls研究是一项由国家老化研究所的新20年流行病学调查，旨在了解4,000名社会经济多样化的非裔美国人（AA）和居住在马里兰州巴尔的摩的白人的健康差异。 Handls的设计独特，旨在将种族和SES与健康成果的各个关系分开。 In HANDLS SCAN we propose to obtain quantitative MRI data from 500 (250 AA, 250 White; ages 30-64) stroke- and dementia-free HANDLS participants with a full range of SES to: (1) Examine race- and SES-related disparities in GM and WM volume, and WM microstructure (2) Examine multi-level mediators - biomedical, behavioral, psychological, social, and environmental - 种族和SES与GM和WM的关系；（3）检查GM和WM是否是种族和SE与认知和身体机能的关系的近端介体。结构方程建模将用于构建越来越复杂的模型，以解决这些相互关联的目标。 PUBLIC HEALTH RELEVANCE: An understanding of multi-level mediators of the relations of race and SES to early and subtle markers of brain pathology, and the relation of brain pathology to cognitive and physical function, is needed to facilitate appropriate strategies in prevention and intervention critical to the reduction and ultimate elimination of health disparities in stroke, dementia, and cognitive and functional decline.