DEVELOPING SUSTAINABLE HIV CLINICAL TRIALS RESEARCH CAPACITY IN UGANDA

描述（由申请人提供）：乌干达是资源有限的国家之一，在那里进行了几次成功的预防母婴艾滋病毒传播（PMTCT）的临床试验。其他几项艾滋病毒预防干预措施以及成人和儿童抗逆转录病毒治疗方面的进展也已从临床试验中实施。尽管在过去10年中临床试验的数量一直在增加，但该国需要相应地增加训练有素的人力资源的能力发展，以开展和监测临床试验。需要增加经过良好培训，能够独立开展艾滋病毒临床试验和相关实验室研究的科研人员、临床试验管理人员和支持人员的数量。我们建议在该国开展和监测艾滋病毒临床试验方面建立一个可持续的培训计划。我们将让马凯雷雷大学医学院及其附属研究机构以及姆巴拉拉（西部）和古卢（北部）等国内的“年轻”大学参与进来。MU-JHU CARE与Makerere传染病研究所（IDI）合作申请了为期两年的计划资助，旨在制定一个研究培训计划，解决预防母婴传播和儿童/成人艾滋病毒治疗的临床试验研究管理问题。我们计划开发一个多学科临床试验研究培训课程，重点是乌干达的研究人员和相关方案小组的工作人员。我们还将确定和发展一支由来自乌干达、非洲、亚洲、欧洲和美国的艾滋病临床试验研究专家组成的世界一流的全球“虚拟”师资队伍。此外，培训咨询小组将为计划中的项目和受训者提供指导，包括2010年的全部培训资助申请。在规划期间和长期内，我们将继续与外国AITRP合作机构进行合作，包括约翰霍普金斯大学、其他美国和欧洲大学，以及其他资助团体，如MRC，它将为乌干达研究人员、联合研究人员和外国合作机构伙伴提供艾滋病研究培训机会。公共卫生相关性：拟议的在乌干达发展与艾滋病毒有关的临床试验研究能力的规划和培训活动与美国国立卫生研究院在乌干达等资源有限的环境中支持的与艾滋病毒有关的研究极为相关。规划拨款将帮助解决NIH加强能力和培训国际研究人员开展艾滋病毒研究的承诺。

DESCRIPTION (provided by applicant): Uganda is one of the resource limited countries where several successful clinical trials on the Prevention of Mother- To- Child HIV Transmission (PMTCT) have been conducted. Several other HIV prevention interventions, as well as advances in adult and pediatric antiretroviral treatment have also been implemented from clinical trials. Whereas the number of clinical trials has been on the rise over the last 10 years, there needs to be a proportional increase in the capacity development of well trained human resource available in the country to conduct and monitor clinical trials. There is a need to increase the numbers of scientific researchers, clinical trial managers and support staff who are well trained to independently conduct HIV clinical trials, and related laboratory research. We propose to create a sustainable training program in the conduct and monitoring of HIV clinical trials in the country. We will involve Makerere University Medical School and the affiliated research Institutions as well as the "young" Universities in the country such as Mbarara (west) and Gulu (north). The 2 year planning grant application from MU-JHU CARE in partnership with the Infectious Diseases Institute (IDI), Makerere aims to develop a research training program addressing management of clinical trials research on PMTCT and pediatric/adult HIV treatment. We plan to develop a multidisciplinary clinical trials research training curriculum focused on Ugandan researchers and allied protocol team staff. We will also identify and develop a world class global "virtual" faculty of HIV clinical trials research experts from Uganda, Africa, Asia, Europe and U.S. In addition, the Training Advisory Group will provide guidance for the planned program and trainees including the full training grant application in 2010. During the planning and in the long term, we will continue ongoing collaborations with foreign AITRP collaborating institutions including Johns Hopkins U. other U.S. and European Universities, and other funding groups such as the MRC which will provide HIV research training opportunities to both Ugandan investigators, allied research staff and foreign collaborating institution partners. PUBLIC HEALTH RELEVANCE: The proposed planning and training activities to develop HIV related Clinical Trials Research Capacity in Uganda are extremely relevant to NIH supported HIV related research in resource limited settings such as Uganda. The Planning grant will help address NIH efforts commitment to capacity strengthening and training of international researchers to carry out HIV research.