DEVELOPING SUSTAINABLE HIV CLINICAL TRIALS RESEARCH CAPACITY IN UGANDA

描述（由申请人提供）：乌干达是一个资源有限的国家，在那里已经进行了几次成功的预防母婴艾滋病毒传播的临床试验。其他几项艾滋病毒预防干预措施以及成人和儿童抗逆转录病毒治疗的进展也已通过临床试验实施。尽管临床试验的数量在过去10年中一直在增加，但该国需要相应地提高训练有素的人力资源的能力，以开展和监测临床试验。有必要增加受过良好培训的科学研究人员、临床试验管理人员和支助人员的人数，以独立进行艾滋病毒临床试验和相关的实验室研究。我们建议在该国开展和监测艾滋病毒临床试验方面建立一个可持续的培训方案。我们将涉及马凯雷雷大学医学院和附属研究机构以及该国的“年轻”大学，如姆巴拉拉（西部）和古卢（北部）。MU-JHU CARE与传染病研究所（IDI）合作的2年规划赠款申请，Makerere旨在开发一个研究培训计划，解决PMTCT和儿科/成人艾滋病治疗临床试验研究的管理问题。我们计划开发一个多学科的临床试验研究培训课程，重点是乌干达研究人员和联合协议团队的工作人员。我们还将确定和发展一个世界级的全球“虚拟”教师的艾滋病毒临床试验研究专家来自乌干达，非洲，亚洲，欧洲和美国，此外，培训咨询小组将提供指导计划的计划和学员，包括在2010年充分的培训补助金申请。在规划和长期的发展中，我们将继续与包括约翰霍普金斯大学在内的国外AITRP合作机构进行合作。其他美国和欧洲大学，以及其他资助团体，如MRC，将为乌干达调查人员、联合研究人员和外国合作机构伙伴提供艾滋病毒研究培训机会。公共卫生相关性：拟议的规划和培训活动，以发展艾滋病毒相关的临床试验研究能力在乌干达是非常相关的国家卫生研究院支持的艾滋病毒相关的研究在资源有限的设置，如乌干达。规划赠款将帮助国家卫生研究所致力于加强国际研究人员开展艾滋病毒研究的能力和培训。

DESCRIPTION (provided by applicant): Uganda is one of the resource limited countries where several successful clinical trials on the Prevention of Mother- To- Child HIV Transmission (PMTCT) have been conducted. Several other HIV prevention interventions, as well as advances in adult and pediatric antiretroviral treatment have also been implemented from clinical trials. Whereas the number of clinical trials has been on the rise over the last 10 years, there needs to be a proportional increase in the capacity development of well trained human resource available in the country to conduct and monitor clinical trials. There is a need to increase the numbers of scientific researchers, clinical trial managers and support staff who are well trained to independently conduct HIV clinical trials, and related laboratory research. We propose to create a sustainable training program in the conduct and monitoring of HIV clinical trials in the country. We will involve Makerere University Medical School and the affiliated research Institutions as well as the "young" Universities in the country such as Mbarara (west) and Gulu (north). The 2 year planning grant application from MU-JHU CARE in partnership with the Infectious Diseases Institute (IDI), Makerere aims to develop a research training program addressing management of clinical trials research on PMTCT and pediatric/adult HIV treatment. We plan to develop a multidisciplinary clinical trials research training curriculum focused on Ugandan researchers and allied protocol team staff. We will also identify and develop a world class global "virtual" faculty of HIV clinical trials research experts from Uganda, Africa, Asia, Europe and U.S. In addition, the Training Advisory Group will provide guidance for the planned program and trainees including the full training grant application in 2010. During the planning and in the long term, we will continue ongoing collaborations with foreign AITRP collaborating institutions including Johns Hopkins U. other U.S. and European Universities, and other funding groups such as the MRC which will provide HIV research training opportunities to both Ugandan investigators, allied research staff and foreign collaborating institution partners. PUBLIC HEALTH RELEVANCE: The proposed planning and training activities to develop HIV related Clinical Trials Research Capacity in Uganda are extremely relevant to NIH supported HIV related research in resource limited settings such as Uganda. The Planning grant will help address NIH efforts commitment to capacity strengthening and training of international researchers to carry out HIV research.