Cocaine and HIV-mediated disruptions of hypothalamic signaling in hypothyroidism

可卡因和艾滋病毒介导的甲状腺功能减退症下丘脑信号传导破坏

• 批准号: 8012744
• 负责人: Dianne Teresa LANGFORD
• 金额: $ 18.68万
• 依托单位: TEMPLE UNIV OF THE COMMONWEALTH
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8012744
• 关键词: Address; Adherence; Adult; Affect; Anti-Retroviral Agents; Astrocytes; Awareness; Back; Behavior; Behavioral; Binding; Biological; Cell Line; Cell Nucleus; Central Nervous System Diseases; Cocaine; Cocaine Abuse; Coculture Techniques; Cognition; Comorbidity; Complication; Conflict (Psychology); DARPP 32; Data; Dementia; Depressed mood; Disease; Disease Progression; Dopamine Receptor; Drug Addiction; Drug abuse; Enzymes; Feedback; Functional disorder; Gene Proteins; HIV; HIV Infections; HIV Seropositivity; Health Personnel; Healthcare; Highly Active Antiretroviral Therapy; Hormones; Human; Hypothalamic structure; Hypothyroidism; Impaired cognition; In Vitro; Individual; Infection; Injection of therapeutic agent; Investigation; Iodide Peroxidase; Lead; Left; Life; Link; Mediating; Mental Depression; Molecular; Monitor; Mood Disorders; Mus; Neuronal Plasticity; Neurons; Nuclear Receptors; Pathway interactions; Patients; Pattern; Pituitary Gland; Plasma; Play; Process; Proteins; Quality of life; Regulation; Research; Research Design; Risk; Role; Signal Transduction; Substance abuse problem; Synapses; Syndrome; System; Testing; Thyroid Diseases; Thyroid Gland; Thyroid Hormones; Thyroxine; Treatment Failure; Unemployment; Virus; Withdrawal; base; cocaine exposure; cohort; design; enzyme activity; mouse model; neurogranin; protein expression; public health relevance; receptor; socioeconomics; substance abuser; treatment program; treatment strategy

DESCRIPTION (provided by applicant): Low socio-economic background, unemployment and depressed environmental surroundings play significant roles in outlook and behavior. Likewise, some individuals suffering from mood disorders may delay seeking healthcare or may not have healthcare benefits and turn to substance abuse (SA) as an alternative. Some comorbidities associated with SA and/or HIV infection directly affect behavior and cognition, and impact significantly on quality of life, adherence to anti-retroviral therapy and successful drug addiction treatment programs. In this context, alterations in thyroid hormone levels have emerged as a complication among some individuals with SA disorders and/or HIV infection, although the molecular basis for the connection is unknown. Our broad hypothesis is that SA and HIV CNS disease contribute to disruptions in the hypothalamic pituitary thyroid (HPT) feedback loop and may lead to or exacerbate hypothyroidism. We propose that these disruptions occur, in part, at the level of hypothalamic signaling and may contribute, in part, to HPT syndrome observed in many individuals who abuse cocaine and are HIV positive. Results from our proposed exploratory study will provide valuable information needed to design more detailed studies addressing: molecular interactions among cocaine, HIV, HAART and CNS HPT signaling impact on cognitive dysfunction, behavior and disease progression treatment strategies for HIV patients with SA disorder at risk for thyroid disease. Our studies are designed to address if cocaine and/or HIV affect pre-existing subclinical or overt hypothyroidism to provide increased awareness among healthcare providers treating substance abuser and/or HIV patients. Left unchecked, the combination of these disorders could lead to increased SA and more rapid disease progression. Results from the proposed studies will increase our understanding of how altered hypothalamic signaling in patients suffering from SA disorders and/or HIV infection may contribute to declining cognition and disease progression, and/or treatment failure. PUBLIC HEALTH RELEVANCE: Alterations in thyroid hormone levels have emerged as a complication among some individuals with SA disorders and/or HIV infection, although the molecular basis for the connection is unknown. Left unchecked, the combination of these disorders could lead to increased SA and more rapid disease progression. Our study will provide information to address molecular interactions among cocaine, HIV, and CNS thyroid signaling.

描述（由申请人提供）：低社会经济背景，失业和抑郁的环境环境在前景和行为中起着重要作用。同样，一些患有情绪障碍的人可能会推迟寻求医疗保健，或者可能没有医疗保健福利，转而使用药物滥用（SA）作为替代方案。与SA和/或HIV感染相关的一些合并症直接影响行为和认知，并显著影响生活质量、抗逆转录病毒治疗依从性和成功的药物成瘾治疗计划。在这种情况下，甲状腺激素水平的改变已经成为一些SA疾病和/或HIV感染个体的并发症，尽管这种联系的分子基础尚不清楚。我们广泛的假设是SA和HIV CNS疾病导致下丘脑垂体甲状腺（HPT）反馈回路中断，并可能导致或加重甲状腺功能减退症。我们认为，这些干扰部分发生在下丘脑信号水平，并可能部分导致在许多滥用可卡因和HIV阳性的个体中观察到的HPT综合征。我们提议的探索性研究的结果将为设计更详细的研究提供有价值的信息，这些研究涉及： 可卡因、HIV、HAART和CNS HPT信号传导之间的分子相互作用 对认知功能障碍、行为和疾病进展的影响 有甲状腺疾病风险的SA疾病HIV患者的治疗策略。 我们的研究旨在解决可卡因和/或艾滋病毒是否会影响预先存在的亚临床或明显的 提高治疗药物滥用者和/或艾滋病毒患者的医疗保健提供者的认识。如果不加以控制，这些疾病的组合可能导致SA增加和疾病进展更快。拟议研究的结果将增加我们对SA疾病和/或HIV感染患者下丘脑信号传导改变如何导致认知能力下降和疾病进展和/或治疗失败的理解。 公共卫生关系：甲状腺激素水平的改变已成为一些SA疾病和/或HIV感染个体的并发症，尽管这种联系的分子基础尚不清楚。如果不加以控制，这些疾病的组合可能导致SA增加和疾病进展更快。我们的研究将提供信息，以解决可卡因，艾滋病毒和中枢神经系统甲状腺信号之间的分子相互作用。