Cancer Biology and Molecular Therapeutics

描述（由申请人提供）：本申请要求继续支持1990年开始的癌症生物学和分子治疗学培训项目。该项目通过参与教学课程、研讨会、讨论小组和实验室研究的表现，培养博士前和博士后的癌症研究基础。该培训项目被纳入莫里斯·科顿癌症中心（国家癌症研究所指定的综合癌症中心）的研究项目中，从而增加了对该疾病许多方面的了解。这是一个多学科的项目，汇集了来自7个不同学术项目的20名教员。最近，在实验和分子医学（PEMM）的伞式项目下，教师们聚集在一起进行新的癌症生物学研究生课程。博士预科生在第一年参加PEMM项目，然后从五个主题中选择一个进行论文研究，期刊俱乐部和研讨会。选择癌症生物学的学生将负责癌症生物学研究生课程的其余培训。要求的教学工作包括癌症生物学、肿瘤基因组学和研究伦理行为课程。目前有43名博士或博士研究生在培训学院的实验室。学生在完成一年或一年以上的研究生课程，并选择一名教师导师后，被招募到培训补助金。这使得他们在第一年的课程和研究轮转中的表现可以作为他们在博士课程中取得成功的潜力的证据。博士后受训者在指导老师的指导下从事全职研究，但通过会议、研讨会和项目活动与其他教师和研究员的定期互动，拓宽了他们的研究经验。学院实验室现有博士后培养人员30人。培训补助资金用于促进博士后培训生的招募，然后鼓励他们获得其他校外资助，从而提高项目招募更多培训生的能力。这一机制也促进了少数族裔申请人的征聘，因为职位更替比较频繁，因此，一旦确定合格的少数族裔，就可以将资金分配给他们。该培训项目自成立以来取得了卓越的成就，新的癌症生物学研究生项目的重点培训将进一步加强这一成就。该计划的新方向在很大程度上是由该培训计划的既定记录实现的，因此，我们要求在目前的培训职位水平上继续提供支持。

DESCRIPTION (provided by applicant): This application requests continued support for a training program in Cancer Biology and Molecular Therapeutics that was begun in 1990. The program trains predoctoral and postdoctoral fellows in the fundamentals of cancer research by participation in didactic courses, seminars, discussion groups and performance of laboratory-based research. The training program is integrated into the research programs of the Morris Cotton Cancer Center, a National Cancer Institute-designated Comprehensive Cancer Center, thereby enhancing exposure to many facets of the disease. This is a multidisciplinary program drawing together 20 faculty with appointments in 7 different academic programs. The faculty have recently been brought together in a new Cancer Biology graduate program under an umbrella Program in Experimental and Molecular Medicine (PEMM). Predoctoral students are enrolled in the PEMM program in year 1 and then select one of five themes in which they undertake their thesis research, journal clubs and seminars. Students who select Cancer Biology then become the responsibility of the Cancer Biology Graduate Program for the remainder of their training. Required didactic work includes courses in Cancer Biology, Oncogenomics, and the Ethical Conduct of Research. Currently there are 43 PhD or MD/PhD students in the laboratories of the training faculty. Students are recruited to the Training Grant after they have completed one or more years in the graduate program, and have selected a faculty mentor. This allows their performance in first year classes and research rotations to be used as evidence of their potential to succeed in the PhD program. Postdoctoral trainees are engaged in fulltime research under the mentorship of a faculty adviser, but have their research experience broadened by regular interactions with other faculty and fellows through conferences, seminars and programmatic activities. There are currently 30 postdoctoral trainees in the laboratories of the faculty. Training grant funds are used to facilitate recruitment of postdoctoral trainees, who then are encouraged to obtain alternate extramural funding, thereby enhancing the ability of the program to recruit additional trainees. This mechanism also facilitates the recruitment of minority applicants as there is a more frequent turnover of positions, and hence funds can be assigned to any qualified minority as soon as identified. This training program has had an outstanding record of achievement since its inception, and this will be further strengthened by the focused training under the new Cancer Biology Graduate Program. This new direction for the program was achieved in major part by the established track record of this training program, and as a consequence we are requesting continued support at the current level of training positions.