HIV Prevention Research and Infrastructure Development in Syria and Middle East

叙利亚和中东的艾滋病毒预防研究和基础设施发展

• 批准号: 8011261
• 负责人: David W Seal
• 金额: $ 23.03万
• 依托单位: MEDICAL COLLEGE OF WISCONSIN
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-08-17 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8011261
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Arab country; Arabs; Award; Awareness; Behavior; Collaborations; Communication; Communities; Community Health Centers; Consultations; Country; Data; Decision Making; Development; Diagnosis; Disease; Disease Outbreaks; Documentation; Drug usage; Education; Effectiveness of Interventions; Enrollment; Ensure; Epidemiology; Ethnography; Feedback; Female; Foundations; Funding; Future; Gatekeeping; Gender Role; HIV; HIV/STD; Health; Health behavior; Human immunodeficiency virus test; Illicit Drugs; Incidence; Individual; Infection; Influentials; Injecting drug user; International; Intervention; Intervention Studies; Intervention Trial; Interview; Learning; Life; Low Prevalence; Measures; Mediation; Mediator of activation protein; Methods; Middle East; Northern Africa; Participant; Phase; Prevalence; Prevention; Prevention Research; Preventive; Preventive Intervention; Prostitution; Provider; Public Health; Recording of previous events; Recruitment Activity; Religion and Spirituality; Research; Research Design; Research Infrastructure; Research Personnel; Risk; Risk Behaviors; Risk Reduction; Scientist; Series; Services; Specific qualifier value; Stigmata; Surveys; Syria; System; Taboo; Testing; Tobacco; Training; Universities; Wisconsin; Women' s Group; Work; base; disease transmission; effective intervention; evidence base; experience; health care delivery; high risk; infrastructure development; insight; intervention program; male; medical schools; men; men who have sex with men; prevent; prevention service; programs; protective behavior; public health relevance; response; sex; social stigma; stem; transmission process

DESCRIPTION (provided by applicant): In response to PAR-08-153 ("Collaborative HIV/AIDS Studies in the Middle East"), the Center for AIDS Intervention Research (CAIR)//Medical College of Wisconsin-- in collaboration with the Center for Community Health (CCH)/University of Memphis and the Syrian Center for Tobacco Studies (SCTS)-- requests 2 years of funding to collect phase 1 formative data about HIV risk behavior among multiple at-risk groups in Syria, including people living with HIV, people seeking STI-related services, commercial sex workers, men who have sex with men, and injection drug users. Data will be used to inform development of culturally-relevant HIV/STI risk reduction interventions for at-risk groups in Syria that can be evaluated in subsequent studies. We also will use think-aloud methods to refine an A-CASI risk behavior survey that will be necessary to evaluate intervention effectiveness in future studies. Toward this end, and in response to PAR-08-153, our proposed study has three primary aims. (1) To identify HIV/STI risk and preventive behaviors, mediators, and moderators that will need to be addressed in a subsequent prevention intervention aimed at groups at high-risk for HIV/STI infection and transmission, including people living with HIV, people seeking STI-related services, female commercial sex workers, men who have sex with men, and injection drug users. (2)To document the feasibility of strategies to access and enroll these groups at high-risk for HIV/STI transmission and infection into a prevention intervention study. (3) To tailor and refine the wording and content of a quantitative risk behavior survey that can be used to evaluate a future HIV/STI prevention intervention trial that based on the lessons learned from this formative study. Our research design and assessment measures will be developed in close consultation with a Community Advisory Board, comprised of influential Religious Scholars and key health delivery and public health stakeholders in Syria. The support of local Religious Scholars and health care delivery systems will enhance our capacity to successfully implement evidence-based public health HIV/STI risk reduction intervention programs. Further, researchers from CAIR and CCH will work closely with researchers at SCTS in Syria to develop local HIV research infrastructure, capacity, and expertise. CAIR researchers have a long history of building local research capacity in non-U.S. countries. Likewise, researchers at CCH and SCTS have developed a very successful health behavior and epidemiological research infrastructure in Syria which has trained many local scientists and won several international awards. The Syrian Project Coordinator is the former Director of HIV Prevention Services for the Syrian Health Ministry. The respective strengths of the collective research teams provide a strong foundation to successfully develop and implement a culturally- competent program of HIV/STI prevention intervention in a low prevalence country before a rapid disease outbreak occurs. Such preemptive efforts are needed to stem the continued global expansion of HIV/STIs, especially in Islamic-Arab countries of the Middle East. Findings from our study will be disseminated for use in the development of HIV/STI risk reduction interventions in Syria, as well as the broader Middle East region given the many sociocultural similarities between Syria and other Arab-Islamic countries in this region. PUBLIC HEALTH RELEVANCE: The development and conduct of a program of culturally-competent HIV/STI prevention intervention research in a low prevalence country can preemptively stem the potential of a rapid outbreak of HIV/STIs. Such preemptive efforts are needed to stem the continued global expansion of HIV/STIs, especially in Islamic- Arab countries of the Middle East-North Africa (MENA) region. Findings from our study will be disseminated for use in the development of HIV/STI risk reduction interventions in Syria, as well as the broader MENA region.

描述（由申请人提供）：为响应PAR-08-153（“中东地区艾滋病毒/艾滋病合作研究”），威斯康星大学艾滋病干预研究中心(CAIR)//威斯康星医学院与孟菲斯大学社区卫生中心（CCH）和叙利亚烟草研究中心（SCTS）合作，要求获得两年的资助，以收集叙利亚多个高危群体中艾滋病毒风险行为的第一阶段形成性数据，包括艾滋病毒感染者、寻求性传播疾病相关服务的人、商业性工作者、男男性行为者和注射吸毒者。数据将用于为叙利亚高危人群制定与文化相关的降低艾滋病毒/性传播感染风险干预措施提供信息，这些干预措施可在随后的研究中进行评估。我们还将使用有声思考方法来完善A-CASI风险行为调查，这将是评估未来研究中干预有效性所必需的。为此，为了响应PAR-08-153，我们提出的研究有三个主要目的。(1)针对HIV/STI感染和传播高危人群，包括HIV感染者、寻求性传播相关服务的人群、女性商业性工作者、男男性行为者和注射吸毒者，确定后续预防干预中需要解决的HIV/STI风险和预防行为、调节因素和调节因素。(2)探讨将这些HIV/STI传播和感染高危人群纳入预防干预研究的策略可行性。(3)定制和完善定量风险行为调查的措辞和内容，该调查可用于评估基于本形成性研究的经验教训的未来艾滋病毒/性传播感染预防干预试验。我们的研究设计和评估措施将与社区咨询委员会密切协商制定，该委员会由叙利亚有影响力的宗教学者和主要的保健服务和公共卫生利益攸关方组成。当地宗教学者和卫生保健系统的支持将增强我们成功实施循证公共卫生艾滋病毒/性传播感染风险降低干预计划的能力。此外，CAIR和CCH的研究人员将与叙利亚SCTS的研究人员密切合作，发展当地的艾滋病研究基础设施、能力和专业知识。CAIR的研究人员在非美国国家建立本地研究能力方面有着悠久的历史。国家。同样，卫生与卫生中心和科学与技术中心的研究人员在叙利亚建立了一个非常成功的健康行为和流行病学研究基础设施，培训了许多当地科学家，并赢得了若干国际奖项。叙利亚项目协调员是叙利亚卫生部艾滋病毒预防服务的前主任。集体研究小组各自的优势为在疾病迅速爆发之前在低流行率国家成功制定和实施具有文化竞争力的艾滋病毒/性传播感染预防干预方案提供了坚实的基础。需要这种先发制人的努力来阻止艾滋病毒/性传播感染在全球继续蔓延，特别是在中东的伊斯兰-阿拉伯国家。鉴于叙利亚与该地区其他阿拉伯-伊斯兰国家之间的许多社会文化相似性，我们的研究结果将被传播，用于在叙利亚以及更广泛的中东地区制定降低艾滋病毒/性传播感染风险的干预措施。