Innovative Modeling of Puberty and Substance Use Risk
青春期和药物使用风险的创新建模
基本信息
- 批准号:7847036
- 负责人:
- 金额:$ 1.5万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2006
- 资助国家:美国
- 起止时间:2006-04-10 至 2009-10-31
- 项目状态:已结题
- 来源:
- 关键词:Acting OutAddressAdolescentAggressive behaviorAlcohol or Other Drugs useAlcoholsArtsBayesian MethodBehaviorBehavioralBiological AssayBrainChildCollaborationsComplexConduct DisorderDataData SetDevelopmentEndocrinologyEnsureEnvironmentFigs - dietaryFundingGoalsHormonalHormonesInstitutionInterdisciplinary StudyInterventionKnowledgeLifeLiteratureLongevityMeasurementMeasuresMediatingMediator of activation proteinMethodologyMethodsModelingOutcomePathway interactionsPositioning AttributeProblem behaviorProcessPsychiatric DiagnosisPsychopathologyPubertyResearchResearch DesignResearch PersonnelResourcesRiskRisk BehaviorsRisk FactorsRoleSamplingStagingStatistical MethodsStatistical ModelsSubstance abuse problemSymptomsTechniquesTheoretical modelTobacco useTreatment/Psychosocial EffectsWorkage groupanalytical methodanti socialbasecomputerized toolscritical periodearly adolescenceexpectationindexinginnovationmeetingsneurochemistrynovelnovel strategiesprogramsresponsestatisticssubstance use preventiontheories
项目摘要
The pubertal transition represents one of the most critical periods for the development of psychopathology
and risk for later substance use due to extensive and simultaneous hormonal, physical, and social-role
changes occurring during this period. Current developmental theories suggest that hormone concentrations
have a direct neurochemical effect and indirect psychosocial effect on risk behavior during the pubertal
transition. Assessing these direct and indirect effects will provide critical knowledge for constructing effective
early substance use prevention or intervention approaches for children and adolescents. However, such
knowledge is lacking due to (a) measurement error in characterization of puberty and (b) lack of adequate
statistical methodology to differentiate direct and indirect effects. In response to the PA-03-044, "Risk
Factors of Psychopathology Using Existing Data Sets", we propose to assess the direct and indirect effects
of hormone concentrations on substance use risk during the pubertal transitional period using an exceptional
datasetfrom an NIH-funded study (5R01MH058393-03). Our novel analytical approach is a synthesis and
extension of two advanced statistical techniques in order to both correct for the measurement error in
puberty and to assess the direct and indirect effects based on statistical causal inference. Our aims are:(1)
To assess direct and indirect effects of hormone concentrations on substance use risk during the pubertal
transition using existing and new methods and to compare the results from both. (2) To develop a more
accurate and informative method and a computational tool for modeling the pubertal maturation process and
correcting for measurement error via a Bayesian approach. (3) To extend our generalized mediational model
for assessing direct and indirect mediational effects considering latent mediator and/or latent outcome
variables. The proposed work is innovative both in the field of substance use and statistical application. The
study is expected to fill the gap of knowledge in early adolescent developmental substance use by examining
pathways between substance use and abuse risk and the rise of hormones during the pubertal transition. It
will also contribute to the statistical literature on modeling longitudinal pubertal maturational process and
complex mediating mechanisms.
青春期是精神病理学发展最关键的时期之一
项目成果
期刊论文数量(3)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Determination of relative timing of pubertal maturation through ordinal logistic modeling: evaluation of growth and timing parameters.
- DOI:10.1016/j.jadohealth.2009.02.013
- 发表时间:2009-10
- 期刊:
- 影响因子:0
- 作者:Huang B;Biro FM;Dorn LD
- 通讯作者:Dorn LD
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{{ truncateString('BIN HUANG', 18)}}的其他基金
Inform Shared Decision-making with Advanced Bayesian Causal Inference to Improve Quality of Pediatric Rheumatology Care
通过高级贝叶斯因果推理为共享决策提供信息,以提高儿科风湿病护理的质量
- 批准号:
10646649 - 财政年份:2023
- 资助金额:
$ 1.5万 - 项目类别:
IGF::OT::IGF EVALUATING FEASIBILITY OF AND POTENTIAL BIASES IN SUPPLEMENTING CANCER REGISTRY DATA USING EXTERNAL SOURCES
IGF::OT::IGF 评估使用外部来源补充癌症登记数据的可行性和潜在偏差
- 批准号:
9161902 - 财政年份:2015
- 资助金额:
$ 1.5万 - 项目类别:
Innovative Modeling of Puberty and Substance Use Risk
青春期和药物使用风险的创新建模
- 批准号:
7222012 - 财政年份:2006
- 资助金额:
$ 1.5万 - 项目类别:
Innovative Modeling of Puberty and Substance Use Risk
青春期和药物使用风险的创新建模
- 批准号:
7342873 - 财政年份:2006
- 资助金额:
$ 1.5万 - 项目类别:
Innovative Modeling of Puberty and Substance Use Risk
青春期和药物使用风险的创新建模
- 批准号:
7563938 - 财政年份:2006
- 资助金额:
$ 1.5万 - 项目类别:
Innovative Modeling of Puberty and Substance Use Risk
青春期和药物使用风险的创新建模
- 批准号:
7102976 - 财政年份:2006
- 资助金额:
$ 1.5万 - 项目类别:
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