Metabolism in Heart Failure Translational Research Center

心力衰竭代谢转化研究中心

• 批准号: 7937864
• 负责人: DONALD W LANDRY
• 金额: $ 51.81万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7937864
• 关键词: Academic Medical Centers; Affect; Appointment; Atrophic; Basic Science; Biology; Cardiology; Cardiomyopathies; Cardiovascular Diseases; Cardiovascular system; Center Core Grants; Center for Translational Science Activities; Clinical; Clinical Research; Commit; Country; Epidemic; Equipment; Exercise; Faculty; Functional disorder; Funding; Gene Expression; Goals; Grant; Growth; Growth Factor; Heart failure; Human; Insulin; Investigation; Laboratories; Lead; Medicine; Metabolic; Metabolism; Molecular; Morphology; Mus; Muscle; Muscle function; Muscular Atrophy; Myocardial; Myocardium; Patients; Pattern; Peripheral; Play; Proteolysis; Recruitment Activity; Research; Research Activity; Role; Series; Signal Transduction; Skeletal Muscle; Testing; Therapeutic; Training; Translational Research; Ubiquitin-mediated Proteolysis Pathway; Wages; Work; career; functional decline; hemodynamics; lipid metabolism; member; mortality; mouse model; muscle metabolism; prevent; programs; protein degradation; response; success; ventricular assist device; wasting

DESCRIPTION (provided by applicant): Columbia University Medical Center (CUMC) contains several large research programs in basic cardiovascular research and clinical heart failure. In response to this P30 program, the Department of Medicine and the Cardiovascular Research Initiative (CVRI) have selected a recently recruited new faculty member whose tenure track appointment will begin on July 1, 2009. Our proposed new faculty member is completing his training in cardiology in the CUMC program, one of the most selective programs in the country. Prior to this he performed studies on the basic biology of skeletal muscle and its abnormalities in patients with heart failure. The proposed research includes clinical and basic studies of the effects of heart failure on muscle biology, concentrating on protein turnover and lipid metabolism. The central hypothesis of this application is that common gene expression patterns and metabolic derangements determine structural and functional changes in the skeletal muscle and myocardium of patients with heart failure, and that those changes are reversible after hemodynamic improvement through ventricular assist device placement. A series of senior collaborators at CUMC will assist in these studies. A career guidance program that includes faculty from several departments has been developed to insure the success of this recruit. Funds from this grant will support the purchase of equipment, provide operating expenses for the proposed clinical and basic research, and will allow the hiring of support staff to assist with the 2 year studies. The Department of Medicine and Division of Cardiology have committed additional funds that guarantee full salary support and some laboratory operating expenses for five years. A major goal of the Department and CVRI is to increase interaction between our clinical and research activities in cardiovascular disease. This recruitment is an effort to do that by adding an outstanding new faculty member focusing on translational research. Heart failure is an expanding worldwide epidemic that already affects more than 5 million people in the US. Exercise intolerance and muscle wasting result from impaired peripheral metabolism and are predictors of mortality in heart failure. This research aims to understand the fundamental interactions of skeletal muscle and myocardial metabolism and function with the ultimate goal of discovering new therapies to prevent or treat the functional decline in patients with heart failure.

描述（由申请人提供）：哥伦比亚大学医学中心（CUMC）包含了基本心血管研究和临床心力衰竭的几个大型研究计划。为了应对该P30计划，医学系和心血管研究计划（CVRI）选择了一个最近招募的新教师，其任期任命将于2009年7月1日开始。我们拟议的新教师正在完成他在CUMC计划中的心脏病学培训，该计划是该国最精选的计划之一。在此之前，他对心力衰竭患者进行了研究骨骼肌及其异常的研究。拟议的研究包括关于心力衰竭对肌肉生物学影响的临床和基础研究，集中在蛋白质更新和脂质代谢上。该应用的中心假设是，常见的基因表达模式和代谢障碍决定了心力衰竭患者的骨骼肌和心肌的结构和功能变化，并且这些变化是通过心室辅助设备放置在血液动力学改善后可逆的。 CUMC的一系列高级合作者将协助这些研究。已经开发了包括来自多个部门的教师在内的职业指导计划，以确保这位新兵的成功。这笔赠款的资金将支持购买设备，为拟议的临床和基础研究提供运营费用，并允许雇用支持人员协助两年研究。医学和心脏病学系已投入额外的资金，以保证五年的全部薪水支持和一些实验室运营费用。该部门和CVRI的主要目标是增加我们在心血管疾病中的临床和研究活动之间的相互作用。这项招聘是通过添加专注于翻译研究的出色新教师来做到这一点的。 心力衰竭是一种不断扩大的全球流行病，已经影响了美国超过500万人。锻炼不耐受性和肌肉浪费是由于周围代谢受损而导致的，并且是心力衰竭死亡率的预测指标。这项研究旨在了解骨骼肌和心肌代谢和功能的基本相互作用，其最终目的是发现新疗法，以防止或治疗心力衰竭患者的功能下降。