Metal Chelators and thiols in Endothelial Function and CVD

P01 AT002034(弗雷)09/30/03-05/31/08 NIH/NCCAM 补充和替代医学抗氧化疗法研究英才中心 (CERCAT) 该计划项目拨款的主要目标是确定氧化和硝化应激在动脉粥样硬化、Lou Gehrig病和衰老动物模型中的作用，以及硫辛酸和金属螯合疗法的保护作用。项目1的主要目标是了解硫醇化合物和过渡金属影响氧化还原敏感细胞信号和转录因子激活的机制，并在炎症和动脉粥样硬化的动物模型中研究硫辛酸和金属螯合剂是否起到抗炎和抗动脉粥样硬化的作用。 通过抑制细胞黏附分子的表达发挥作用。 职位：项目主任、项目1负责人(内皮功能和心血管疾病方面的金属络合剂和硫醇)和行政核心主任

P01 AT002034 (Frei) 09/30/03-05/31/08 NIH/NCCAM Center of Excellence for Research on Complementary and Alternative Medicine Antioxidant Therapies (CERCAT) The major goals of this program project grant are to determine the roles of oxidative and nitrative stress in animal models of atherosclerosis, Lou Gehrig's disease, and aging, and the protective effects of lipoic acid and metal chelation therapy. The major goals of Project 1 (Metal Chelators and Thiols in Endothelial Function and CVD) are to understand the mechanisms by which thiol compounds and transition metals affect redoxsensitive cellular signaling and transcription factor activation; and to investigate in animal models of inflammation and atherosclerosis whether lipoic acid and metal chelators exert anti-inflammatory and antiatherosclerotic effects by inhibiting cellular adhesion molecule expression. Roles: Program Director, Project 1 Leader (Metal Chelators and Thiols in Endothelial Function and CVD), and Administrative Core Director