Brain reward as a link between insulin resistance and weight status in Hispanic c

大脑奖励作为西班牙裔美国人胰岛素抵抗和体重状况之间的联系

• 批准号: 8111017
• 负责人: Tanja Cornelia Adam
• 金额: $ 1.56万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-15 至 2011-10-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111017
• 关键词: Age; Anatomy; Anterior; Applications Grants; Area; Biometry; Body Weight; Brain; Brain imaging; Cardiovascular Diseases; Child; Childhood; Corpus striatum structure; Data; Disease; Dorsal; Eating; Event; Evolution; Exposure to; Feedback; Feeding behaviors; Food; Food Intake Regulation; Foundations; Functional Magnetic Resonance Imaging; Goals; Grant; Hispanics; Human; Hyperphagia; Image; Imaging technology; Insulin; Insulin Receptor; Insulin Resistance; Investigation; Knowledge; Link; Measurement; Mediating; Mentors; Mentorship; Methodology; Motivation; Neurons; Neurosciences; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Participant; Peripheral; Play; Population; Prevalence; Prevention; Regulation; Research; Research Personnel; Research Proposals; Rewards; Risk Factors; Role; Solid; Structure; Technology; Testing; Training; Training Activity; Ventral Tegmental Area; Weight; Work; Writing; aged; career; career development; design; disorder risk; energy balance; graduate student; human subject; improved; infancy; insulin sensitivity; interest; neuroimaging; obesity in children; obesity prevention; obesity treatment; pleasure; relating to nervous system; resistance mechanism; response; reward circuitry; reward processing; skills; successful intervention; symposium

DESCRIPTION (provided by applicant): The overall goal of this proposal is to examine the effect of different degrees of insulin resistance on brain reward circuits in obese and normal-weight Hispanic children. Brain reward circuit activity will be determined using functional magnetic resonance imaging (fMRI) in two groups of Hispanic children (aged 8 - 11 years) who provide a large range of insulin resistance. This proposal is a first step in testing the unifying hypothesis that peripheral insulin resistance is not only a consequence of obesity but in turn contributes to positive energy balance through a disruption of central food intake regulation. Furthermore, the research proposal is designed to provide important training to prepare me for an independent and inter-disciplinary research career. Dr. Adam's immediate career goals are to: 1) become an expert in the use of fMRI as well as analyze the collected data to help elucidate the central mechanisms of food intake regulation; 2) expand knowledge on mechanisms of food intake regulation, obesity and type 2 diabetes to the pediatric population; 3) become competent in research regarding brain anatomy and the different anatomical structures that are involved in reward processing; 4) deepen knowledge about the mechanistic relationship between insulin sensitivity and obesity; and, 5) mentor undergraduate and graduate students in preparing them for careers in prevention and treatment of childhood obesity and type 2 diabetes. The overall long-term career goal is to become an independent and inter-disciplinary investigator focused on the understanding of food intake regulation in childhood obesity. The specific training activities associated with this KO1 will involve: 1) direct mentorship from Dr.Michael Goran, Dr. Richard Bergman, Dr. Dianne Lattemann, Dr. Zhong-Lin Lu and Dr. Weigensberg; 2) attending seminars and formal classes to be trained in the subject areas and methodological skills necessary to complete the study as well as in career development (eg neuroscience; fMRI methodology; biostatistics; grant writing); and 3) attend conferences to improve scientific expertise, create a professional network and provide exposure to present and discuss study findings. PUBLIC HEALTH RELEVANCE: The proposed study will examine how insulin resistance may not only be a consequence of obesity but also a cause for overeating through a disruption of central food intake regulation. The results will substantiate the importance of insulin sensitivity as a primary target for obesity treatment and early age intervention for successful prevention of obesity.

描述(申请人提供)：这项提案的总体目标是研究不同程度的胰岛素抵抗对肥胖和正常体重的西班牙裔儿童大脑奖赏回路的影响。将使用功能磁共振成像(FMRI)来确定两组西班牙裔儿童(年龄在8-11岁)的大脑奖励电路活动，这些儿童提供了广泛的胰岛素抵抗。这项建议是检验统一假说的第一步，该假说认为外周胰岛素抵抗不仅是肥胖的结果，而且反过来通过扰乱中央食物摄入调节来促进正能量平衡。此外，研究提案旨在提供重要的培训，为我独立和跨学科的研究生涯做好准备。Adam博士近期的职业目标是：1)成为功能磁共振成像使用方面的专家，并分析收集的数据，以帮助阐明食物摄入量调节的核心机制；2)将食物摄入量调节机制、肥胖症和2型糖尿病的知识扩大到儿科人群；3)精通大脑解剖学和与奖赏处理相关的不同解剖结构的研究；4)加深关于胰岛素敏感性和肥胖症之间的机制关系的知识；以及5)指导本科生和研究生，为他们将来从事儿童肥胖症和2型糖尿病的预防和治疗工作做好准备。总体的长期职业目标是成为一名独立和跨学科的调查者，专注于了解儿童肥胖的食物摄入量调节。与KO1相关的具体培训活动将包括：1)来自Michael Goran博士、Richard Bergman博士、Dianne Ltemann博士、Luong-Lin Lu博士和Weigensberg博士的直接指导；2)参加研讨会和正式课程，接受完成研究所需的学科领域和方法技能以及职业发展方面的培训(例如，神经科学；功能磁共振成像方法学；生物统计学；拨款撰写)；以及3)参加会议，以提高科学专业知识，创建专业网络，并提供展示和讨论研究结果的机会。 与公共健康相关：这项拟议的研究将研究胰岛素抵抗如何不仅是肥胖的结果，而且是通过扰乱中央食物摄入调节而导致暴饮暴食的原因。这一结果将证实胰岛素敏感性作为肥胖治疗和早期干预成功预防肥胖的主要目标的重要性。