The Role of Heme Metabolic Pathways in T Cell Development and T Cell Lymphomagene

血红素代谢途径在 T 细胞发育和 T 细胞淋巴瘤基因中的作用

基本信息

  • 批准号:
    8091845
  • 负责人:
  • 金额:
    $ 16.74万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2011
  • 资助国家:
    美国
  • 起止时间:
    2011-07-01 至 2016-06-30
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): Dr. Mary Philip is a motivated senior hematology/oncology fellow with a strong background in the basic biology of cancer and immunology. Her immediate goals are to understand the role of heme in regulating T cell development and T cell lymphoma development. Dr. Philip has observed that developing T cells that lack FLVCR, a heme export protein, fail to complete development in the thymus. In recent years there has been growing awareness of the role of metabolic dysregulation in cancer development and immune function. Though heme synthesis and regulation are integral parts of overall cellular metabolism, little is known about the role of heme metabolism in T cell development. Dr. Philip will use mouse models to determine how modulation of heme levels affects the development and function of normal T cells as well as the development of T cell lymphomas. Dr. Philip will carry out this research under the guidance of Dr. Janis Abkowitz, a leading researcher in the field of heme and iron transport and hematopoiesis with a proven track record of successful mentorship. The Abkowitz lab provides an excellent environment with the necessary resources to carry out the molecular and immunologic studies to complete these studies. The Abkowitz lab is located at the University of Washington, a leader in the fields of hematopoiesis and immunology with many resources available for the study of T cell biology. There is an exceptional community of scientists in immunology and other disciplines to provide advice and collaboration. Dr. Philip also has access to the faculty and facilities of the Fred Hutchinson Cancer Research Center, the leader in the study and use of hematopoietic stem cell transplantation and immunotherapy to treat cancers. In the long-term, Dr. Philip plans to combine the skills and insights from her clinical training and experience treating patients with leukemia and lymphoma with her strong basic science and research training to pursue a career as a clinician-scientist. Her career development plan proposes a curriculum of research, didactic coursework, participation in local and national meetings, and structured mentorship with Dr. Abkowitz and the members of her Scientific Advisory Committee to achieve this goal. PUBLIC HEALTH RELEVANCE: Though major advances have been made in understanding the genetic changes that lead to cancer, most cancer patients eventually die from their disease because their cancer cells become resistant to therapy. By studying the metabolic changes that underlie T cell development and T cell lymphoma development, this research aims to uncover new targets for cancer therapy and to find ways to prevent cancer cells from resisting treatment.
描述(由申请人提供):玛丽菲利普博士是一名积极的高级血液学/肿瘤学研究员,在癌症和免疫学的基础生物学方面具有很强的背景。她的近期目标是了解血红素在调节T细胞发育和T细胞淋巴瘤发展中的作用。菲利普博士观察到,缺乏FLVCR(一种血红素输出蛋白)的发育中的T细胞无法在胸腺中完成发育。近年来,人们越来越认识到代谢失调在癌症发展和免疫功能中的作用。虽然血红素合成和调节是整体细胞代谢的组成部分,但对血红素代谢在T细胞发育中的作用知之甚少。菲利普博士将使用小鼠模型来确定血红素水平的调节如何影响正常T细胞的发育和功能以及T细胞淋巴瘤的发展。菲利普博士将在Janis Abkowitz博士的指导下开展这项研究,Janis Abkowitz博士是血红素和铁运输和造血领域的领先研究人员,具有成功指导的良好记录。Abkowitz实验室为开展分子和免疫学研究提供了良好的环境和必要的资源,以完成这些研究。Abkowitz实验室位于华盛顿大学,是造血和免疫学领域的领导者,拥有许多可用于T细胞生物学研究的资源。有一个特殊的免疫学和其他学科的科学家社区提供建议和合作。菲利普博士还可以使用弗雷德哈钦森癌症研究中心的教师和设施,该中心是研究和使用造血干细胞移植和免疫疗法治疗癌症的领导者。从长远来看,菲利普博士计划将她的临床培训和治疗白血病和淋巴瘤患者的经验与她强大的基础科学和研究培训的技能和见解联合收割机相结合,以追求临床科学家的职业生涯。她的职业发展计划提出了一个研究,教学课程,在地方和国家会议的参与,并与博士结构辅导。 公共卫生相关性:虽然在理解导致癌症的遗传变化方面取得了重大进展,但大多数癌症患者最终死于疾病,因为他们的癌细胞对治疗产生了抗药性。通过研究T细胞发育和T细胞淋巴瘤发展的代谢变化,这项研究旨在发现癌症治疗的新靶点,并找到防止癌细胞抵抗治疗的方法。

项目成果

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Mary Philip其他文献

Mary Philip的其他文献

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{{ truncateString('Mary Philip', 18)}}的其他基金

TCR signaling and cell cycle regulation in tumor-specific CD8 T cell dysfunction
肿瘤特异性 CD8 T 细胞功能障碍中的 TCR 信号传导和细胞周期调控
  • 批准号:
    10599306
  • 财政年份:
    2022
  • 资助金额:
    $ 16.74万
  • 项目类别:
TCR signaling and cell cycle regulation in tumor-specific CD8 T cell dysfunction
肿瘤特异性 CD8 T 细胞功能障碍中的 TCR 信号传导和细胞周期调控
  • 批准号:
    10446019
  • 财政年份:
    2022
  • 资助金额:
    $ 16.74万
  • 项目类别:
The Role of Heme Metabolic Pathways in T Cell Development and T Cell Lymphomagene
血红素代谢途径在 T 细胞发育和 T 细胞淋巴瘤基因中的作用
  • 批准号:
    8293070
  • 财政年份:
    2011
  • 资助金额:
    $ 16.74万
  • 项目类别:
The Role of Heme Metabolic Pathways in T Cell Development and T Cell Lymphomagene
血红素代谢途径在 T 细胞发育和 T 细胞淋巴瘤基因中的作用
  • 批准号:
    8481211
  • 财政年份:
    2011
  • 资助金额:
    $ 16.74万
  • 项目类别:

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