Quality of Life in Prostate Cancer Project

前列腺癌生活质量项目

• 批准号: 7940345
• 负责人: Christine Sheehan Brennan
• 金额: $ 37.46万
• 依托单位: LSU HEALTH SCIENCES CENTER
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-01 至 2013-09-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7940345
• 关键词: Address; African American; Alcohol consumption; American; Behavior; Belief; Cancer Etiology; Cancer Survivor; Cessation of life; Communities; Comorbidity; Comorbidity Index; Data; Data Collection; Data Set; Diagnosis; Dietary intake; Education; Enrollment; Epidemiologic Studies; Ethnic Origin; Family; Follow-Up Studies; Geographic Locations; Goals; Habits; Health; Health Care Seeking Behavior; Health Services Accessibility; Healthcare; Healthcare Systems; Healthy People 2010; Incidence; Income; Insurance; Interdisciplinary Study; Life; Life Style; Louisiana; Malignant neoplasm of prostate; Measures; Mediator of activation protein; Medical; Medicine; Methods; North Carolina; Outcome; Physical activity; Physicians; Procedures; Prognostic Factor; Prospective Studies; Quality of life; Questionnaires; Race; Relative (related person); Reporting; Research Priority; Risk; Smoking; Socioeconomic Factors; Surveys; Testing; Trust; United States; arm; base; cancer health disparity; caucasian American; cohort; cost efficient; design; disorder control; follow-up; health care service utilization; health disparity; health related quality of life; instrument; lifestyle factors; literacy; mortality; population based; prospective; public health relevance; racial difference; socioeconomics

DESCRIPTION (provided by applicant): In the United States, prostate cancer is the second leading cause of cancer-related death, with consistent outcome disparities between African Americans (AA) and Caucasian Americans (CA). Many studies have reported the various factors associated with racial differences in prostate cancer incidence and mortality between AA and CA. Little is known about the racial differences in Health Related Quality of Life (HRQOL) between AA and CA, especially the pre-diagnosis lifestyle (healthy behaviors) factors, socioeconomic (SES) factors and healthcare seeking behaviors and beliefs associated with the differences of HRQOL. Our primary hypothesis is that racial differences in long-term prostate cancer HRQOL are the results of racial differences in healthy behaviors prior to diagnosis, SES and healthcare seeking behaviors and beliefs. A population-based prospective study, the Quality of Life Prostate Cancer Project (Q-PCaP), is proposed to address this issue. Q-PCaP is a follow-up study built upon the North Carolina-Louisiana Prostate Cancer Project (PCaP), which was a population-based study conducted from July 2004 through August 2009 for the Louisiana part. Q-PCaP will collect follow up HRQOL data among the Louisiana cohort of PCaP and conduct secondary analysis of the PCaP baseline data set. All analyses will control for disease aggressiveness at initial diagnosis and primary treatment methods. Q-PCaP is designed to evaluate factors contributing to disparities in prostate cancer, particularly prostate cancer HRQOL in order to facilitate efforts to decrease disparities and enhance HRQOL in prostate cancer survivors. PUBLIC HEALTH RELEVANCE: HRQoL and HBL are potentially modifiable factors that may contribute to racial differences in PCa outcomes; however, these factors have not been directly evaluated as mediators of racial disparities. Eliminating health disparities and increasing the quality and years of healthy life available to all are the primary goals of the Healthy People 2010, and determining theunderlying causes and extent of cancer health disparities through expanded epidemiologic research is also central to the NCI Challenge Goal 2015 strategic initiative "Overcoming Health Disparities". While employing a multidisciplinary research approach to investigate the full spectrum of causal factors responsible for the disparity between race/ethnicity regarding health outcomes, the proposed Q-PCAP study will address this critical research priority in a cost efficient manner by conducting a population-based prospective follow-up study of the LA PCaP cohort.

描述（由申请人提供）：在美国，前列腺癌是癌症相关死亡的第二大原因，非裔美国人 (AA) 和白种人美国人 (CA) 之间的结局差异始终存在。 许多研究报告了与 AA 和 CA 之间前列腺癌发病率和死亡率的种族差异相关的各种因素。人们对 AA 和 CA 之间健康相关生活质量 (HRQOL) 的种族差异知之甚少，特别是诊断前生活方式（健康行为）因素、社会经济 (SES) 因素和医疗保健寻求 与 HRQOL 差异相关的行为和信念。我们的主要假设是 长期前列腺癌 HRQOL 的种族差异是诊断前健康行为、SES 以及就医行为和信念的种族差异的结果。一项基于人群的前瞻性研究，即生活质量前列腺癌项目 (Q-PCaP)，旨在解决这个问题。 Q-PCaP 是一项基于北卡罗来纳州-路易斯安那州前列腺癌项目 (PCaP) 的后续研究，该项目是 2004 年 7 月至 2009 年 8 月针对路易斯安那州部分进行的一项基于人群的研究。 Q-PCaP 将收集路易斯安那州 PCaP 队列中的后续 HRQOL 数据，并对 PCaP 基线数据集进行二次分析。所有分析都将在初始诊断和主要治疗方法中控制疾病的侵袭性。 Q-PCaP 旨在评估导致前列腺癌，特别是前列腺癌 HRQOL 差异的因素，以促进减少前列腺癌幸存者的差异并提高 HRQOL 的努力。 公共卫生相关性：HRQoL 和 HBL 是潜在可改变的因素，可能会导致 PCa 结果的种族差异；然而，这些因素尚未被直接评估为种族差异的调节因素。消除健康差距、提高所有人的健康生活质量和寿命是《2010 年健康人民》的主要目标，并通过扩大流行病学研究来确定癌症健康差距的根本原因和程度。 研究也是 NCI 2015 年挑战目标战略举措“克服健康差距”的核心。在采用多学科研究方法来调查造成种族/族裔之间健康结果差异的全方位因果因素的同时，拟议的 Q-PCAP 研究将以成本效益的方式通过对洛杉矶 PCAP 进行基于人群的前瞻性后续研究来解决这一关键研究优先事项 队列。

项目成果

Unit Nonresponse in a Population-Based Study of Prostate Cancer.

基于人群的前列腺癌研究中的单位无反应。

• DOI: 10.1371/journal.pone.0168364
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Oral,Evrim;Simonsen,Neal;Brennan,Christine;Berken,Jennifer;Su,LJoseph;Mohler,JamesL;Bensen,JeannetteT;Fontham,ElizabethTH
• 通讯作者: Fontham,ElizabethTH