FASEB Summer Research Conference titled "THE LUNG EPITHELIUM IN HEALTH AND DISEAS

描述（由申请人提供）： 本申请要求部分资金为FASEB夏季研究会议题为肺上皮细胞在健康和疾病，将于2010年8月8日至13日在佛蒙特州学院，萨克顿河，佛蒙特州。出席人数限制为160人，以创造有利于与会者之间互动的气氛。本次会议的总体目标是提供一个论坛，介绍有关调节正常肺上皮细胞和发育生物学的分子机制的新的和前沿的信息，以及如何在肺部疾病中改变这些信息。本次会议的具体议题包括：（1）肺形态发生和细胞命运的分子调控;（2）正常和病变肺中气道上皮细胞功能的新概念;（3）肺泡上皮细胞和表面活性物质生物学;（4）介导急性肺上皮损伤及其修复的分子机制;（5）肺组织病理学;（6）肺组织病理学。（5）肺上皮细胞保护的范例，包括ER应激、自噬和程序性细胞死亡;（7）肺上皮干/祖细胞、上皮-间充质转化及其在肺修复和疾病中的参与;（8）先天免疫和粘膜免疫在调节气道和肺泡内的炎症稳态中的作用。我们相信，这次会议是独特的，及时的，非常重要的;它将汇集公认的专家在肺上皮生物学社区内的强烈兴趣的领域，在一个场地，旨在传播新的信息，并促进建立和初级研究人员的互动。我们相信，这次会议将提供一个新的方法和方向，为未来的研究肺上皮细胞生物学的框架。 公共卫生相关性： 肺是将吸入的氧气转移到血液中以及将呼出的二氧化碳释放回大气中的关键器官。肺的气道和气体交换囊由上皮细胞排列，上皮细胞对正常肺功能至关重要。这些细胞不仅进行空气和气体交换，还有助于个人对吸入颗粒，污染物和微生物的防御。调节肺上皮正常发育的机制仅部分了解。此外，关于肺上皮如何对损伤作出反应以恢复正常功能以及在疾病中如何失调，仍有许多有待了解。本次会议将汇集肺部生物学领域及其他领域的公认专家，他们将分享和讨论他们最近的重要发现，最终目标是制定更好的策略，以改善对肺部疾病的理解和治疗。

DESCRIPTION (provided by applicant): This application requests partial funding for a FASEB Summer Research Conference entitled Lung Epithelium in Health and Disease, to be held August 8 - 13, 2010 at The Vermont Academy, Saxtons River, VT. Attendance is limited to 160 persons to create a climate conducive to interaction among the participants. The overall objective of this conference is to provide a forum for presenting new and cutting-edge information regarding the molecular mechanisms regulating the cell and developmental biology of the normal lung epithelium, and how these may be altered in lung disease. The specific topics to be covered in this conference include: (1) Molecular regulation of lung morphogenesis and cell fate commitment; (2) New concepts in airway epithelial cell function in the normal and diseased lung; (3) Alveolar epithelial cell and surfactant biology; (4) Molecular mechanisms mediating acute lung epithelial injury and its repair; (5) Paradigms for lung epithelial cytoprotection including ER stress, autophagy, and programmed cell death; (6) Molecular and genetic pathways underlying specific rare lung diseases; (7) Lung epithelial stem/progenitor cells, epithelial- mesenchymal transition, and their involvement in lung repair and disease; (8) The role of innate and mucosal immunity in regulating inflammatory homeostasis within the airways and alveoli. We believe that this meeting is unique, timely, and highly important; it will bring together recognized experts in areas of intense interest within the lung epithelial biology community in a venue designed to both disseminate new information and to promote the interaction of established and junior investigators. We believe that this meeting will provide a framework for novel approaches and directions for future research on lung epithelial cell biology. PUBLIC HEALTH RELEVANCE: The lung is the critical organ where inhaled oxygen is transferred to the blood and where exhaled carbon dioxide is released back into the atmosphere. The airways and gas-exchanging sacs of the lung are lined by epithelial cells that are critical for normal lung function. These cells not only act in conducting air and gas exchange, but also contribute to the individual's defense against inhaled particles, pollutants, and microorganisms. Mechanisms that regulate the normal development of the lung epithelium are only partially understood. Furthermore, much remains to be learned about how the lung epithelium responds to injury to restore normal function and is disregulated in disease. This conference will bring together recognized experts in the field of lung biology and beyond who will share and discuss their recent important findings, with the ultimate goal of devising better strategies to improve understanding and treatment of lung disease.