2010 Mammary Gland Biology GRC

2010年乳腺生物学GRC

• 批准号: 7905344
• 负责人: D. Joseph Jerry
• 金额: $ 1.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-06-01 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7905344
• 关键词: Adopted; Affect; Biological; Biology; Breast Cancer Prevention; Breast Cancer Treatment; Cessation of life; Child; Collaborations; Developing Countries; Development; Environmental Exposure; European; Fostering; Friendships; Funding; International; Lactation; Mammary gland; Nutritional; Pathway interactions; Prevention; Request for Proposals; Research; Research Personnel; Risk; Running; Site; Students; Time; Trust; United States National Institutes of Health; Woman; Work; cancer risk; expectation; falls; lifestyle factors; lifetime risk; malignant breast neoplasm; mammary gland development; meetings; multidisciplinary; public health relevance; social; success; symposium; unpublished works

DESCRIPTION (provided by applicant): This application seeks three years of funding support for the 23rd-25th Gordon Research Conference (GRC) on Mammary Gland Biology. This long-established conference is one of just a few annual meetings that falls into the "must-attend" class for mammary biologists and breast cancer researchers. The meeting aims to integrate research into the how the mechanisms underlying normal mammary gland development and environmental exposures contribute to both the risk and prevention of breast cancer as well as assuring competent lactation to meet the nutritional needs of children around the world. This multidisciplinary conference is the key meeting for the dissemination of findings that reveal the aberrant biological features of breast cancer by placing them into the context of normal function. The unique Gordon Conference format, where researchers share three meals per day and mandated social time over a working week, encourages the friendship and trust that very fosters both incisive discussions and the initiation of collaborative ventures. It is also the only meeting in this highly competitive field that maintains the tradition and expectation of revealing unpublished work. It also offers students and postdocs unprecedented access and exposure with a large number of slots reserved for presentations by this group. The international participation offers opportunities for unique perspectives and collaborations. For all of the reasons above, the demand for places at the Mammary Gland Biology GRC is high, as evidenced by the fact that it is one of the most popular conferences run by the GRC. To meet demand the GRC organization places this conference in their largest venues, and unlike most GRCs, the Mammary Gland Biology GRC is run every year, alternating between European and US sites fostering international collaborations. Even by adopting annual conferences, demand for the meeting routinely exceeds the limits placed on the conference by venue seating capacity. Further, the conference routinely receives high praise from its attendees when polled by the GRC organization, emphasizing the high value this conference provides to the attendees. The Mammary Gland Biology GRC has received unbroken NIH support for more than 6 years. This support has underpinned the success of the conference. To assure the continuity of its success, this proposal requests support for the next three conference years. PUBLIC HEALTH RELEVANCE: The lifetime risk of developing breast cancer is currently 1 in 8 among women in the U.S.A., with over 190,000 cases of invasive breast cancer and 40,000 deaths expected in 2009 alone. Though less frequent in developing countries the rates of breast cancer are rising at alarming rates underscoring the environmental and lifestyle factors that contribute to breast cancer. The Mammary Gland Biology Gordon Research Conference is an international conference dedicated to (i) understanding the developmental pathways that assure competent lactation to meet the nutritional needs of children around the world, (ii) how perturbations in developmental pathways and environmental exposures affect breast cancer risk and (iii) identify targets for prevention and treatment of breast cancer.

描述（由申请人提供）：本申请寻求三年的资金支持，为第23 - 25届戈登研究会议（GRC）乳腺生物学。这个历史悠久的会议是为数不多的几个年度会议之一，福尔斯落入“必须参加”类乳腺生物学家和乳腺癌研究人员。该会议旨在将研究纳入正常乳腺发育和环境暴露的机制如何有助于乳腺癌的风险和预防，以及确保合格的哺乳以满足世界各地儿童的营养需求。这个多学科会议是传播研究结果的关键会议，这些研究结果通过将乳腺癌的异常生物学特征置于正常功能的背景下来揭示乳腺癌的异常生物学特征。 独特的戈登会议形式，研究人员每天分享三餐，并在一个工作周内规定社交时间，鼓励友谊和信任，非常促进深刻的讨论和合作企业的启动。它也是这个竞争激烈的领域中唯一保持揭示未发表作品的传统和期望的会议。它还为学生和博士后提供了前所未有的访问和曝光机会，并为该小组的演讲预留了大量的空间。国际参与为独特的观点和合作提供了机会。 由于上述所有原因，对乳腺生物学GRC的需求很高，这是由GRC举办的最受欢迎的会议之一。为了满足需求，GRC组织将这次会议放在他们最大的场地，与大多数GRC不同的是，乳腺生物学GRC每年都会举办，在欧洲和美国的网站之间交替进行，以促进国际合作。即使采用年度会议，对会议的需求也经常超过会议场地座位容量的限制。此外，在GRC组织的调查中，会议经常受到与会者的高度赞扬，强调了会议为与会者提供的高价值。 乳腺生物学GRC已经获得了超过6年的持续NIH支持。这种支持是会议成功的基础。为确保其成功的延续性，本建议要求在今后三个会议年得到支持。 公共卫生相关性：在美国，患乳腺癌的终生风险目前是八分之一，预计仅2009年就有超过190，000例浸润性乳腺癌病例和40，000例死亡。虽然在发展中国家发病率较低，但乳腺癌的发病率正在以惊人的速度上升，这突出表明环境和生活方式因素是导致乳腺癌的原因。乳腺生物学戈登研究会议是一个国际会议，致力于（i）了解确保有能力哺乳的发育途径，以满足世界各地儿童的营养需求，（ii）发育途径和环境暴露的干扰如何影响乳腺癌风险，以及（iii）确定预防和治疗乳腺癌的目标。