2010 Gordon Res Conference on Epilepsy & Mechanisms of Neuronal Synchronization

描述（由申请人提供）：我们要求nds支持将于2010年8月8日至13日在缅因州科尔比学院举行的戈登癫痫和神经元同步机制研究会议。癫痫发作研究的主要目标是确定神经元网络中同步放电的机制，以便开发更有效和毒性更小的癫痫治疗和治愈方法。癫痫研究的一个独特的、具有智力挑战性的方面源于这样一个事实：它几乎涵盖了生物组织的所有主要层面，从基因和离子通道到电路和行为。戈登会议的主要目的是将遗传学家、分子生物学家、发育神经科学家、神经解剖学家、电生理学家和计算神经科学家聚集在一起，共同研究与癫痫发作直接或间接相关的基本机制，综合当前的进展，为未来的发现奠定基础。本次会议的主题是神经回路和癫痫，涉及的主题包括：微电路动力学：同步性的出现；抑制性神经元：传递失败；神经炎症和癫痫；电路稳态：癫痫的分析和实验方法癫痫的表观遗传学、基因调控及microrna研究电路发育和功能：癫痫网络的基础；干细胞与癫痫；癫痫发生：隐性和显性机制；癫痫离子通道和突触蛋白。我们的目标是传播最新的科学进展，培养富有成效的新见解和合作，并为新的转化研究奠定基础，从而在最短的时间内将最新的发现带到床边。

DESCRIPTION (provided by applicant): We are requesting NINDS support for a Gordon Research Conference on Mechanisms of Epilepsy and Neuronal Synchronization to be held August 8-13, 2010 at Colby College in Maine. The main goal of the study of seizures is to identify the mechanisms underlying synchronous electrical discharges in neuronal networks in order to develop more effective and less toxic treatments and cures for epilepsy. A unique, intellectually challenging aspect of epilepsy research arises from the fact that it encompasses virtually all major levels of biological organization, from genes and ion channels to circuits and behavior. The major purpose of this Gordon conference is to bring together geneticists, molecular biologists, developmental neuroscientists, neuroanatomists, electrophysiologists, and computational neuroscientists working on basic mechanisms related either directly or indirectly to seizure generation to synthesize current advances and set the stage for future discoveries. The theme of the current conference is Neural Circuits and Epilepsy, and topics to be covered include: Microcircuit Dynamics: Emergence of synchrony; Inhibitory neurons: failure to deliver; Neuroinflammation and Epilepsy; Circuit Homeostasis: Analytical and Experimental approaches in Epilepsy; Epigenetics, gene regulation and microRNAs in Epilepsy; Circuit development and function: basis for epileptic networks; Stem Cells and Epilepsy; Epileptogenesis: occult and overt mechanisms; and Epileptic ion channels and synaptic proteins. Our goals are to disseminate the latest scientific advances, foster productive new insights and collaborations, and set the stage for new translational studies that will bring the newest discoveries to the bedside in the shortest possible time. PUBLIC HEALTH RELEVANCE: Epilepsy is a chronic condition that affects 50 million people worldwide. Development of novel therapeutic strategies to better treat and potentially cure this devastating condition requires scientific advances to better understand the molecular and cellular mechanisms responsible for epilepsy. This conference will bring together experts from all over the world in an intensive, immersive environment to present and discuss novel findings, facilitating dissemination of knowledge and spawning collaborations. This should significantly advance research directed towards better treatment of epilepsy.