9th International Congress of Vertebrate Morphology: Jaw Development Symposium

描述(由申请人提供)：本次R13申请的目的是为了支持在2010年7月26日至7月31日举行的第九届国际脊椎动物形态学大会(ICVM)的会议专题讨论会。研讨会的题目是“形态多样性的产生：脊椎动物颌骨进化的发育机制”，这是一个与NIDCR的任务直接相关的主题，目的是通过研究、研究培训和健康信息传播来改善口腔、牙齿和颅面健康。总体而言，颌骨研讨会将提供基于疾病的颌骨模式的观点，并由8名演讲者组成，他们将介绍正常和异常颌骨结构和功能的进化和发育机制。Shigeru Kuratani博士(RIKEN发育生物学中心)将比较无颌脊椎动物和有颌脊椎动物之间的基因进化、神经脊发育和模式形成机制。加州大学欧文分校的Thomas Shling博士将报告导致颌骨形态变化的分子信号相互作用和发育调控途径。阿比盖尔·塔克博士(国王学院)将解释转录因子调控的时空变化以及咽内皮细胞分泌分子的表达是如何影响下颌弓图案的。加州大学旧金山分校的Richard Schneider博士将详细介绍神经脊在调控颌骨复合体中的基因表达、肌肉骨骼分化和模式形成中的作用。杜克大学的凯瑟琳·史密斯博士将描述与哺乳动物颌骨复合体发育相关的关键分子和细胞事件；国王学院的Michael Depew博士将提供基于小鼠突变的遗传模型，揭示在发育和疾病期间塑造颌骨骨骼的程序和事件。帕特里夏·珀塞尔博士(哈佛大学)将介绍驱动颞颌关节正常和不正常模式和整合的分子线索。Paul Trainor博士(Stower‘s Institute)将解释颅面组织之间的基本细胞功能和信号相互作用如何影响颌骨的图案化生长，特别是在人类出生缺陷的背景下。演讲者包括来自美国和其他国家的女性和科学界代表性不足的群体，演讲将涉及一系列模型系统和实验方法。拉丁美洲还没有举行过这样规模或规模相当的科学会议。因此，JAW专题讨论会和ICVM-9总体上将为美国、欧洲、亚洲的研究人员与拉丁美洲的研究人员之间建立新的科学合作提供一个无与伦比的论坛。此外，JAW研讨会将提供一个独特的机会，将西班牙裔、拉丁裔和土著美国血统的学生招募到这些人仍然代表不足的领域。因此，联合专家小组讨论会将是一个宝贵的招聘工具，可以增加我们领域的多样性。请拨的预算用于支助8名已确认发言者每人的经济舱机票和现场住宿费用。 与公共卫生相关：影响颌骨的畸形是人类最常见的先天缺陷之一。识别形成颌骨模式的分子和细胞机制对于设计新的治疗策略并最终预防此类出生缺陷至关重要。拟议的颌骨研讨会旨在解决颌骨模式的问题，促进这一领域的新研究合作，并招募不同的人才到颅面生物学领域。

DESCRIPTION (provided by applicant): The objective of this R13 application is to support a Conference Symposium to be held in conjunction with the 9th International Congress of Vertebrate Morphology (ICVM) on July 26th to July 31st, 2010. The Symposium is entitled, "Generation of Morphological Diversity: Developmental Mechanisms of Vertebrate Jaw Evolution" which is a topic directly related to the NIDCR mission to improve oral, dental, and craniofacial health through research, research training, and the dissemination of health information. Overall, the Jaw Symposium will provide disease-based perspectives on jaw patterning and consist of eight speakers who will present evolutionary and developmental mechanisms of normal and abnormal jaw structure and function. Dr. Shigeru Kuratani (RIKEN Center for Developmental Biology) will compare gene evolution, neural crest development, and patterning mechanisms between jawless and jawed vertebrates. Dr. Thomas Shilling (UC Irvine) will report on molecular signaling interactions and developmental regulatory pathways that generate changes in jaw morphology. Dr. Abigail Tucker (King's College) will explain how spatiotemporal changes in transcription factor regulation as well as expression of secreted molecules by the pharyngeal endoderm underlie mandibular arch patterning. Dr. Richard Schneider (UC San Francisco) will provide details on the role of the neural crest in regulating gene expression, musculoskeletal differentiation, and pattern formation in the jaw complex. Dr. Kathleen Smith (Duke University) will describe key molecular and cellular events that are associated with the development of the mammalian jaw complex; Dr. Michael Depew (King's College) will offer a genetic model based on mouse mutants that sheds light on programs and events that shape the jaw skeleton during development and disease. Dr. Patricia Purcell (Harvard University) will present on molecular cues that drive the normal and abnormal patterning and integration of the temporomandibular joint. Dr. Paul Trainor (Stower's Institute) will explain how basic cellular functions and signaling interactions among craniofacial tissues influence the patterned outgrowth of the jaw, especially in the context of human birth defects. The speakers include women and underrepresented groups in science from the United States as well as other countries, and the presentations will span a range of model systems and experimental approaches. There has not been an equivalent scientific meeting of this kind or magnitude in Latin America. Thus, the Jaw Symposium and the ICVM-9 in general will offer an unparalleled forum for the establishment of new scientific collaborations between researchers from the United States, Europe, Asia, with their counterparts from Latin America. Moreover, the Jaw Symposium will present a unique opportunity to recruit students of Hispanic, Latino, and indigenous American ancestry into a field where such individuals continue to be underrepresented. Thus, the Jaw Symposium will be an invaluable recruitment tool to add diversity to our field. The requested budget is to provide support for coach class airfare and on-site lodging expenses for each of the eight confirmed speakers. PUBLIC HEALTH RELEVANCE: Malformations that affect the jaws are some of the most common human birth defects. Identifying molecular and cellular mechanisms that pattern the jaws is crucial for devising novel treatment strategies and ultimately for preventing such birth defects. The proposed Jaw Symposium seeks to address questions of jaw patterning, facilitate new research collaborations in this area, and recruit diverse talent to the field of craniofacial biology.