9th International Congress of Vertebrate Morphology: Jaw Development Symposium

描述（由申请人提供）：本R13申请的目的是支持将于2010年7月26日至7月31日与第9届国际脊椎动物形态学大会（ICVM）一起举行的会议专题讨论会。研讨会的题目是“形态多样性的产生：脊椎动物颌骨进化的发育机制”，这是一个与NIDCR使命直接相关的主题，即通过研究、研究培训和健康信息的传播来改善口腔、牙齿和颅面健康。总体而言，颌骨研讨会将提供基于疾病的颌骨模式的观点，并由八位发言人组成，他们将介绍正常和异常颌骨结构和功能的进化和发展机制。Shigeru Kuratani博士（RIKEN发育生物学中心）将比较无颌和有颌脊椎动物之间的基因进化，神经嵴发育和模式机制。托马斯希林博士（加州大学欧文分校）将报告分子信号相互作用和发育调节途径，产生变化的颌骨形态。Abigail Tucker博士（国王学院）将解释转录因子调节的时空变化以及咽内胚层分泌分子的表达是下颌弓模式的基础。Richard Schneider博士（加州大学旧金山分校弗朗西斯科）将提供有关神经嵴在调节基因表达、肌肉骨骼分化和颌骨复合体模式形成中的作用的详细信息。Kathleen Smith博士（杜克大学）将描述与哺乳动物颌骨复合体发育相关的关键分子和细胞事件; Michael Depew博士（国王学院）将提供一个基于小鼠突变体的遗传模型，该模型揭示了在发育和疾病期间塑造颌骨骨骼的程序和事件。帕特里夏珀塞尔博士（哈佛大学）将介绍分子线索，驱动正常和异常的模式和整合的颞下颌关节。Paul Trainor博士（Stower研究所）将解释颅面组织之间的基本细胞功能和信号相互作用如何影响颌骨的模式化生长，特别是在人类出生缺陷的背景下。演讲者包括来自美国和其他国家的女性和代表性不足的科学团体，演讲将涵盖一系列模型系统和实验方法。在拉丁美洲还没有举行过这种或这种规模的同等科学会议。因此，Jaw研讨会和ICVM-9将为来自美国，欧洲，亚洲的研究人员与拉丁美洲的同行之间建立新的科学合作提供一个无与伦比的论坛。此外，下颌研讨会将提供一个独特的机会，招募西班牙裔，拉丁裔和土著美国血统的学生进入一个领域，这些人继续代表性不足。因此，下颌研讨会将是一个宝贵的招聘工具，以增加多样性，我们的领域。请拨的预算将用于支付已确认的8名发言者每人的经济舱机票和现场住宿费用。 公共卫生相关性：影响颌骨的畸形是一些最常见的人类出生缺陷。确定分子和细胞机制，模式的下巴是至关重要的设计新的治疗策略，并最终防止这种出生缺陷。拟议的下颌研讨会旨在解决下颌模式的问题，促进在这一领域的新的研究合作，并招募不同的人才到颅面生物学领域。

DESCRIPTION (provided by applicant): The objective of this R13 application is to support a Conference Symposium to be held in conjunction with the 9th International Congress of Vertebrate Morphology (ICVM) on July 26th to July 31st, 2010. The Symposium is entitled, "Generation of Morphological Diversity: Developmental Mechanisms of Vertebrate Jaw Evolution" which is a topic directly related to the NIDCR mission to improve oral, dental, and craniofacial health through research, research training, and the dissemination of health information. Overall, the Jaw Symposium will provide disease-based perspectives on jaw patterning and consist of eight speakers who will present evolutionary and developmental mechanisms of normal and abnormal jaw structure and function. Dr. Shigeru Kuratani (RIKEN Center for Developmental Biology) will compare gene evolution, neural crest development, and patterning mechanisms between jawless and jawed vertebrates. Dr. Thomas Shilling (UC Irvine) will report on molecular signaling interactions and developmental regulatory pathways that generate changes in jaw morphology. Dr. Abigail Tucker (King's College) will explain how spatiotemporal changes in transcription factor regulation as well as expression of secreted molecules by the pharyngeal endoderm underlie mandibular arch patterning. Dr. Richard Schneider (UC San Francisco) will provide details on the role of the neural crest in regulating gene expression, musculoskeletal differentiation, and pattern formation in the jaw complex. Dr. Kathleen Smith (Duke University) will describe key molecular and cellular events that are associated with the development of the mammalian jaw complex; Dr. Michael Depew (King's College) will offer a genetic model based on mouse mutants that sheds light on programs and events that shape the jaw skeleton during development and disease. Dr. Patricia Purcell (Harvard University) will present on molecular cues that drive the normal and abnormal patterning and integration of the temporomandibular joint. Dr. Paul Trainor (Stower's Institute) will explain how basic cellular functions and signaling interactions among craniofacial tissues influence the patterned outgrowth of the jaw, especially in the context of human birth defects. The speakers include women and underrepresented groups in science from the United States as well as other countries, and the presentations will span a range of model systems and experimental approaches. There has not been an equivalent scientific meeting of this kind or magnitude in Latin America. Thus, the Jaw Symposium and the ICVM-9 in general will offer an unparalleled forum for the establishment of new scientific collaborations between researchers from the United States, Europe, Asia, with their counterparts from Latin America. Moreover, the Jaw Symposium will present a unique opportunity to recruit students of Hispanic, Latino, and indigenous American ancestry into a field where such individuals continue to be underrepresented. Thus, the Jaw Symposium will be an invaluable recruitment tool to add diversity to our field. The requested budget is to provide support for coach class airfare and on-site lodging expenses for each of the eight confirmed speakers. PUBLIC HEALTH RELEVANCE: Malformations that affect the jaws are some of the most common human birth defects. Identifying molecular and cellular mechanisms that pattern the jaws is crucial for devising novel treatment strategies and ultimately for preventing such birth defects. The proposed Jaw Symposium seeks to address questions of jaw patterning, facilitate new research collaborations in this area, and recruit diverse talent to the field of craniofacial biology.