2010 Lipoprotein Metabolism GRC

描述（由申请人提供）： 我们要求部分支持2010年戈登研究会议脂蛋白代谢将在沃特维尔谷度假村，新罕布什尔州6月20日至25日举行。会议将重点关注脂蛋白代谢的重要新进展，包括基础分子和细胞生物学研究，代谢的动物模型，新的治疗方法和人体研究。主席塔巴斯博士与过去的主席、2012年主席和该领域的领导人协商，计划了九次口头会议：第一次会议：富含甘油三酯的脂蛋白的代谢和清除第二次会议：HDL和ABC转运蛋白第三次会议：脂蛋白和细胞：细胞固醇运输和代谢第四次会议：脂蛋白、脂质和大脑第五次会议：LDL受体调节：细胞机制和治疗潜力会议6：脂滴和细胞脂质代谢会议7：改善血浆脂蛋白谱的治疗方法会议8：肝脏脂质和脂蛋白代谢会议9：特别主题演讲会议：脂质代谢的新发现我们的会议满足NHLBI使命的各个方面。首先，我们汇集了脂蛋白代谢方面的国际领导者，这一机制占全球心血管风险负担的30%。第二，与性别有关的遗传学，生物学，生物化学和脂蛋白的临床表现的问题已经确定，所以我们的会议满足NHLBI的责任，解决这些问题的妇女。此外，主旨发言人和会议主席都是妇女，非裔美国人Debose-Boyd博士将是第三次会议的主要发言人。此外，我们的会议经过精心协调，包括与心血管疾病的原因，预防，诊断和治疗相关的研究的多样性。第四，NHLBI传统上支持我们的会议，我们很荣幸地邀请NHLBI行政部门的选定成员参加。第五，我们赞同NHLBI对预防的优先考虑;事实上，在我们过去的会议上首次报告了当今广泛常规临床使用的心血管疾病一级和二级预防的关键方面（例如他汀类药物）。第六，主席最优先重视个人在培训初期和职业发展初期的参与：9/37确认的发言者是年轻的调查人员，大约有200人。为提交摘要和海报的年轻调查人员和受训人员保留了20个简短的口头报告。我们将为尽可能多的参与者提供最大限度的财务支持，我们的财务计划需要NIH为此提供支持。最后，该计划有来自美国和国际与会者的多民族参与，计划为至少6名少数民族与会者提供资金援助，前提是我们的会议预算足以为这些人以及其他与会者提供支持。所有戈登研究会议都在符合《美国残疾人法》规定的会议空间举行。公共卫生相关性：戈登脂蛋白研究会议已经存在了30多年，2010年将汇集脂蛋白代谢方面的国际和国家领导人，脂蛋白代谢途径占全球心血管疾病风险负担的30%。将涵盖的关键方面包括脂蛋白代谢的重要新发展，包括基本的分子和细胞生物学研究，动物模型的代谢，新的治疗方法和人体研究。会议鼓励科学家展示未发表的工作，并提供了无与伦比的讨论和互动机会，重点是为年轻的研究人员和学员提供接触机会。

DESCRIPTION (provided by applicant): We request partial support of the 2010 Gordon Research Conference on Lipoprotein Metabolism to be held at Waterville Valley Resort, NH on June 20-25. The conference will focus on important new developments in lipoprotein metabolism, including basic molecular and cell biological studies, animal models of metabolism, new therapeutic approaches, and human studies. The Chair, Dr. Tabas, in consultation with past chairs, the 2012 chair, and leaders in the field, have planned nine oral sessions: Session 1: Metabolism and Clearance of Triglyceride-Rich Lipoproteins Session 2: HDL and ABC transporters Session 3: Lipoproteins and Cells: Cellular Sterol Trafficking and Metabolism Session 4: Lipoproteins, Lipids, and the Brain Session 5: LDL Receptor Regulation: Cellular Mechanisms and Therapeutic Potential Session 6: Lipid Droplets and Cellular Lipid Metabolism Session 7: Therapeutic Approaches to Improving Plasma Lipoprotein Profile Session 8: Hepatic Lipid and Lipoprotein Metabolism Session 9: Special Keynote Session: New Discoveries in Lipid Metabolism Our conference satisfies all aspects of the NHLBI Mission. First, we bring together international leaders in lipoprotein metabolism, a mechanism that accounts for 30% of global cardiovascular risk burden. Second, gender-related issues of genetics, biology, biochemistry and clinical manifestations of lipoproteins have been identified, so our conference satisfies the NHLBI responsibility for addressing these issues in women. Also, both key note speakers and a session chair are women, and an African-American, Dr. Debose-Boyd, will be a major speaker in Session 3. Furthermore, our conference has been carefully coordinated to include diversity of research related to the causes, prevention, diagnosis and treatment of cardiovascular disease. Fourth, the NHLBI has traditionally supported our meeting and we have been honored to invite selected members of NHLBI administration as attendees. Fifth, we share the NHLBI's priority on prevention; indeed key aspects of primary and secondary prevention of cardiovascular disease that are in widespread routine clinical use today (e.g. statin drugs) were first reported at our past meetings. Sixth, the Chair has placed the highest priority on participation by individuals early in their training and early in their career development: 9/37 confirmed speakers are young investigators and approx. 20 short oral presentations are reserved for young investigators and trainees who submit abstracts and posters. We will maximize financial support for as many participants as possible and our financial plan requires NIH support for this purpose. Finally, the program has multi-ethnic participation from both US and international attendees, with funding assistance planned for at least 6 of the minority participants providing our conference budget is sufficient to provide support to these individuals as well as other conference participants. All Gordon Research Conferences are held in meeting spaces that conform to the regulations of the Americans with Disabilities Act. PUBLIC HEALTH RELEVANCE: The Gordon Research Conference on Lipoproteins has been in existence for more than 30 years and in 2010 will bring together international and national leaders in lipoprotein metabolism, a pathway that accounts for up to 30% of the global risk burden of cardiovascular disease. Key aspects that will be covered include important new developments in lipoprotein metabolism, including basic molecular and cell biological studies, animal models of metabolism, new therapeutic approaches, and human studies. The conference encourages scientists to present unpublished work and provides unparalleled opportunities for discussion and interaction, with a heavy emphasis on providing exposure for young investigators and trainees.