2010 Neural Development Gordon Research Conference

描述(由申请人提供)：神经系统执行的复杂功能需要高度协调和精确调控的发育程序。这些程序的变化已被证明是许多神经元障碍的基础，包括自闭症、行为综合征和神经退行性变。因此，全面了解神经系统发育的基本机制，对于合理设计治疗和行为策略以对抗这些疾病是至关重要的。2010年神经发展戈登研究会议的目标是聚集老牌和新兴的研究人员，讨论最近的研究突破，以促进互动和合作，并加强翻译研究的基础。会议的总主题将围绕分子遗传学方法，以及跨物种研究在我们理解神经发育原理方面的作用。该会议自1981年以来每两年举行一次，并已成为该领域的首屈一指的会议，不断吸引著名的国内和国际研究人员，以及学生和博士后研究员在一个小型的互动环境中进行深入的科学讨论。会议的形式是以口头陈述为中心，然后进行广泛的讨论，高度互动的海报会议，以及非正式会议的“自由”时间，允许互动的水平和深度，这在其他大型会议中是罕见的。2010年的会议将讨论9个主题，包括脑模式；神经干细胞；细胞命运指定；神经元形态、模式和突起；突触发展；关键技术突破；神经基因表达的调控；电路的发展；以及退化和再生。在制定该方案时，注意邀请最近取得令人兴奋的突破并在其研究中使用各种模型系统和多种方法(包括分子、遗传和细胞)的发言者。该项目还包括国内和国际演讲者，以及高级和初级研究人员。确认的发言人中有41%是女性。根据以前的历史，我们预计2010年神经发展GRC将同样成功地加深我们对神经元发育的理解，并促进翻译研究的战略，以解决人类神经发育病理。 公共卫生相关性：研究会议为传播研究成果和建立导致新见解的合作提供了一个重要论坛。2010年戈登神经发展研究会议预计将通过进一步了解中枢和外周神经系统发育的基本机制，以及这些机制在疾病中是如何被破坏的，从而影响公众健康。使用多种实验方法研究不同模型系统的研究人员之间的讨论和互动有望导致新的研究方向的启动，导致新的治疗策略的开发和合理药物设计的靶点的确定。

DESCRIPTION (provided by applicant): The complex functions carried out by the nervous system demand highly orchestrated and precisely regulated developmental programs. Alterations in these programs have been shown to underlie many neuronal disorders including autism, behavioral syndromes, and neurodegeneration. Thus, a complete understanding of the basic mechanisms of nervous system development is essential for a rational design of therapeutic and behavioral strategies to combat these disorders. The goal of the 2010 Neural Development Gordon Research conference is to bring together established and rising investigators to discuss recent research breakthroughs, in order to foster interactions and collaborations, and to strengthen the foundation for translational research. The overall theme of the meeting will center around a molecular genetic approach, and the role of cross-species investigations in our understanding of neurodevelopmental principles. This conference has been held biannually since 1981, and has become the premier conference in this field that consistently attracts prominent national and international researchers, as well as students and postdoctoral fellows in a small, interactive setting for in depth scientific discussions. The format of the meeting which is centered around oral presentations followed by extensive discussions, highly interactive poster sessions, and 'free' time for informal meetings allows a level and depth of interaction that is rarely found at other, larger conferences. The 2010 conference will cover 9 themes including brain patterning; neuronal stem cells; cell fate specification; neuronal morphology, patterning and outgrowth; synaptic development; key technological breakthroughs; regulation of neuronal gene expression; development of circuits; and degeneration and regeneration. In developing the program, attention was paid to inviting speakers who have made recent exciting breakthroughs and who use a variety of model systems and multiple approaches including molecular, genetic and cellular, in their research. The program also includes national and international speakers, as well as both senior and junior researchers. 41% of the confirmed speakers are women. Based on prior history, we expect that the 2010 Neural Development GRC will be similarly successful in furthering our understanding of neuronal development, and in promoting strategies for translational research to address human neurodevelopmental pathologies. PUBLIC HEALTH RELEVANCE: Research conferences provide a critical forum for the dissemination of research findings, and for the establishment of collaborations leading to novel insights. The 2010 Gordon Research Conference in Neural Development is expected to impact public health by furthering our understanding of the basic mechanisms by which the central and peripheral nervous systems develop, and how these mechanisms are disrupted in diseases. Discussions and interactions among researchers working on different model systems using multiple experimental approaches is expected to result in the initiation of novel research directions, leading to the development of new therapeutic strategies and the identification of targets for rational drug design.