2010 Intermediate Filaments Gordon Research Conference

2010年中间长丝戈登研究会议

• 批准号: 7907318
• 负责人: ROBERT D GOLDMAN
• 金额: $ 1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-15 至 2011-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7907318
• 关键词: Architecture; Biomedical Research; Bulla; Cardiac; Cardiomyopathies; Cell Shape; Cell physiology; Cells; Code; Communities; Complex; Cytoskeleton; Defect; Disease; Elements; Gene Family; Genes; Genetic Transcription; Histocompatibility Testing; Inflammation; Intermediate Filament Proteins; Intermediate Filaments; Keratin; Lamins; Link; Mechanics; Muscular Dystrophies; Mutation; Neurodegenerative Disorders; Nuclear; Play; Premature aging syndrome; Protein Biosynthesis; Regulation; Research; Research Personnel; Role; Signal Transduction; Skeletal Muscle; Structural Protein; Structure; Tissues; cell motility; design; human disease; insight; interest; protein folding; resilience; skin disorder; symposium

DESCRIPTION (provided by applicant): Intermediate Filaments (IFs) are important structural elements of the eukaryotic cytoskeleton and nucleoskeleton. They represent one of the largest gene families, with over 70 genes coding for different IF that are tissue type specific and expressed in a developmentally regulated manner. They provide stability as well as mechanical resilience to the cell cytoskeleton. Recent studies on their interaction with other cytoskeletal and nucleoskeletal elements provide important insights into their unique role in structure and function of cells in many different tissues. Recent biomedical research has demonstrated that defects in IF are responsible for a great many human diseases ranging from blistering skin diseases to muscular dystrophy and premature aging disorders. These findings, combined with recent studies showing the regulation of protein biosynthesis by keratins and transcription control by lamins demands a revision of the classical view of IF proteins as primarily structural proteins and necessitates linking IF research to other research communities with an interest in protein folding, inflammation and signaling. The upcoming GRC on IF proteins is designed to expose established IF research groups to researchers from different fields, offering an opportunity to investigate complex problems such as the role of IF in cardiac, skeletal muscle and neurodegenerative diseases.

描述（由申请人提供）：中间丝（if）是真核细胞骨架和核骨架的重要结构元素。它们代表了最大的基因家族之一，有超过70个基因编码不同的IF，这些基因是组织类型特异性的，并以发育调节的方式表达。它们为细胞骨架提供稳定性和机械弹性。最近对它们与其他细胞骨架和核骨架元件相互作用的研究，为它们在许多不同组织中细胞的结构和功能中的独特作用提供了重要的见解。最近的生物医学研究表明，IF中的缺陷是许多人类疾病的原因，从皮肤起泡病到肌肉萎缩症和早衰症。这些发现，结合最近的研究表明，角蛋白调节蛋白质生物合成和层合蛋白的转录控制，要求对IF蛋白主要作为结构蛋白的经典观点进行修订，并需要将IF研究与其他对蛋白质折叠，炎症和信号传导感兴趣的研究团体联系起来。即将到来的IF蛋白GRC旨在让已有的IF研究小组接触到来自不同领域的研究人员，为研究IF在心脏、骨骼肌和神经退行性疾病中的作用等复杂问题提供机会。