MEDICINAL CHEMISTRY, CHEMICAL SYNTHESIS, AND MASS SPECTROMETRY
药物化学、化学合成和质谱分析
基本信息
- 批准号:8168768
- 负责人:
- 金额:$ 0.01万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2010
- 资助国家:美国
- 起止时间:2010-03-10 至 2010-12-31
- 项目状态:已结题
- 来源:
- 关键词:Acetylcholinesterase InhibitorsAfrica South of the SaharaAlkylationAlzheimer&aposs DiseaseAnopheles gambiaeAreaBenzodiazepinesChemistryComputer Retrieval of Information on Scientific Projects DatabaseCulicidaeFundingGrantInsecticidesInstitutionInterest GroupMalariaMass Spectrum AnalysisMethodsMultinuclear NMRNMR SpectroscopyOrganic SynthesisPathway interactionsPharmaceutical ChemistryReactionReagentResearchResearch PersonnelResourcesRouteSSRI-resistant depressionSourceStructureUnited States National Institutes of HealthWorkbasebeta secretasebeta-site APP cleaving enzyme 1chemical synthesisinhibitor/antagonistinterestnovelpreventreuptaketransmission process
项目摘要
This subproject is one of many research subprojects utilizing the
resources provided by a Center grant funded by NIH/NCRR. The subproject and
investigator (PI) may have received primary funding from another NIH source,
and thus could be represented in other CRISP entries. The institution listed is
for the Center, which is not necessarily the institution for the investigator.
Medicinal Chemistry. The Carlier group's interests in Medicinal Chemistry encompass three areas. First, they prepare species-selective inhibitors of acetylcholinesterase (AChE) targeting the malaria mosquito (Anopheles gambiae). Such compounds could be deployed on insecticide treated nets to prevent malaria transmission in sub-Saharan Africa. Second, they use click-chemistry based discovery methods to identify BACE1 (beta-secretase) inhibitors; such compounds could be to useful to prevent Alzheimer's disease. Finally, they prepare novel triple reuptake inhibitors to treat SSRI-resistant depression.
Enantioselective Synthetic Methods. Organolithium reagents are ubiquitous in organic synthesis. The Carlier group is interested in developing new stereoselective reactions of organolithium compounds and enolates, and in using computation and multinuclear NMR spectroscopy to determine structures and reaction pathways. Recently they developed an enantioselective alkylation route to a new class of (so-called "quaternary") benzodiazepines. A key feature of this work is the intermediacy of transiently non-racemic ("dynamically chiral") intermediates.
这个子项目是众多研究子项目之一
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Paul R Carlier其他文献
Paul R Carlier的其他文献
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{{ truncateString('Paul R Carlier', 18)}}的其他基金
Optimization of antimalarials targeting multiple life stages of the parasite
针对寄生虫多个生命阶段的抗疟药物的优化
- 批准号:
10745610 - 财政年份:2021
- 资助金额:
$ 0.01万 - 项目类别:
Optimization of antimalarials targeting multiple life stages of the parasite
针对寄生虫多个生命阶段的抗疟药物的优化
- 批准号:
10298005 - 财政年份:2021
- 资助金额:
$ 0.01万 - 项目类别:
Optimization of antimalarials targeting multiple life stages of the parasite
针对寄生虫多个生命阶段的抗疟药物的优化
- 批准号:
10813425 - 财政年份:2021
- 资助金额:
$ 0.01万 - 项目类别:
Optimization of antimalarials targeting multiple life stages of the parasite
针对寄生虫多个生命阶段的抗疟药物的优化
- 批准号:
10689033 - 财政年份:2021
- 资助金额:
$ 0.01万 - 项目类别:
Interrogating plasmodial endocytosis with mefloquine-based affinity probes
用基于甲氟喹的亲和探针检测疟原虫内吞作用
- 批准号:
10089405 - 财政年份:2020
- 资助金额:
$ 0.01万 - 项目类别:
MEDICINAL CHEMISTRY, CHEMICAL SYNTHESIS, AND MASS SPECTROMETRY
药物化学、化学合成和质谱分析
- 批准号:
7954019 - 财政年份:2009
- 资助金额:
$ 0.01万 - 项目类别:
Development of vector-specific, resistance-breaking insecticides to reduce malari
开发病媒特异性、突破耐药性的杀虫剂以减少疟疾
- 批准号:
8445236 - 财政年份:2009
- 资助金额:
$ 0.01万 - 项目类别:
Development of vector-specific, resistance-breaking insecticides to reduce malari
开发病媒特异性、突破耐药性的杀虫剂以减少疟疾
- 批准号:
8237040 - 财政年份:2009
- 资助金额:
$ 0.01万 - 项目类别:
Development of vector-specific, resistance-breaking insecticides to reduce malari
开发针对病媒的抗药性杀虫剂以减少疟疾
- 批准号:
7657602 - 财政年份:2009
- 资助金额:
$ 0.01万 - 项目类别:
Development of vector-specific, resistance-breaking insecticides to reduce malari
开发针对病媒的抗药性杀虫剂以减少疟疾
- 批准号:
7796794 - 财政年份:2009
- 资助金额:
$ 0.01万 - 项目类别:
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