N-DEMETHYLATION IS A MAJOR ROUTE OF 2-AMINO-3-METHYLIMIDAZO[4,5-F]

这个子项目是许多研究子项目中的一个 由NIH/NCRR资助的中心赠款提供的资源。子项目和 研究者（PI）可能从另一个NIH来源获得了主要资金， 因此可以在其他CRISP条目中表示。所列机构为 研究中心，而研究中心不一定是研究者所在的机构。 在小鼠中评价2-氨基-3-甲基咪唑并[4，5-f]喹啉（IQ）代谢，以更好地了解其致瘤性。将经口给予40 mg/kg [（14）C]IQ的小鼠的尿液代谢物与类似处理的大鼠的尿液代谢物进行比较。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. 2-Amino-3-methylimidazo[4,5-f]quinoline (IQ) metabolism was evaluated in mouse to better understand its tumorigenicity. Urinary metabolites from mice orally administered 40 mg/kg [(14)C]IQ were compared with those from similarly treated rats.