AOSSM Post-joint Injury Conference II

AOSSM 关节损伤后会议 II

基本信息

批准号：
8062988
负责人：
CONSTANCE R CHU
金额：
$ 2.5万
依托单位：
AMERICAN ORTHOPAEDIC SOCIETY/SPORTS MED
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-06 至 2011-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8062988
关键词：
Acute Address American Arts Biochemical Biological Markers Cartilage injury Clinical Clinical Research Clinical assessments Communication Research Degenerative polyarthritis Development Disease Early Diagnosis Education Emotional End stage renal failure Fellowship Fracture Goals Health Heart failure Image Impairment Individual Injury Joint Dislocation Joints Knee Lead Life Life Style Lower Extremity Measurement Methods Modality Multi-Institutional Clinical Trial ORALIT Orthopedics Outcome Patients Recommendation Reporting Research Research Design Risk Scientist Site Societies Sports Medicine Surgeon Techniques arthropathies articular cartilage burden of illness cohort design disability high risk human subject injured joint function joint injury kinematics meetings member prevent programs prospective restoration socioeconomics symposium

项目摘要

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most common joint disease and is a leading cause of disability worldwide [1,2]. The physical impairment from OA of a single lower extremity joint is equivalent to that reported for major life-altering disorders such as end-stage kidney disease and heart failure [3]. The causes of OA are not well understood. However, joint trauma is a leading etiological factor [1,2,4]. Intra-articular fracture, joint dislocations, and other joint injuries can lead to post-traumatic osteoarthritis. Although they are a subset of joint trauma, ACL and meniscal injuries are the most common injuries treated by orthopaedic surgeons [11, 12]. Despite recent advances in operative and non-operative treatment of ACL injuries, patients sustaining ACL and related injuries suffer a 50% chance of compromised knee function ten years after injury and have a ten-fold increased risk of OA compared to those who did not have a joint injury [13-15]. Formed in 1972 primarily as a forum for dissemination of developments in clinical technique and new research findings, the American Orthopaedic Society for Sports Medicine (AOSSM) is now a world leader in sports medicine education, research, communication, and fellowship. The Society and its members focus on the treatment of injuries commonly sustained by active individuals and the restoration of active lifestyles. The AOSSM recognizes the physical, emotional, and socioeconomic burdens joint injury and post-traumatic OA places on athletes, active individuals, and society in general. The AOSSM Post-joint Injury Osteoarthritis Conference II will be held December 2-5, 2010 in New Orleans, LA at the Ritz-Carlton New Orleans. The meeting is timely, and a logical follow-on to the momentum generated from the AOSSM/NIH R-13 Post-joint Injury Osteoarthritis Conference held December 11-14, 2008. The proposed conference brings together leaders in clinical research and experts in new quantitative clinical assessment modalities together to discuss and design a multi-center clinical study of human subjects following ACL injury for the possible development of a clinical initiative addressing post-joint injury OA. SIGNIFICANCE: The ultimate goal of establishing prospective clinical study cohorts of individuals at risk for post-traumatic OA is to facilitate the development of new collaborative approaches for early disease modifying treatments. Successful approaches would be potentially more broadly applicable not only to joint injury in general and also to the early diagnosis and treatment of cartilage injury and degeneration as strategies to reduce the total disease burden of osteoarthritis.

描述（由申请人提供）：骨关节炎（OA）是最常见的关节疾病，是全球残疾的主要原因[1,2]。单个下肢关节的OA的身体损害等同于报道的主要改变生命的疾病，例如终末期肾脏疾病和心力衰竭[3]。 OA的原因尚不清楚。然而，关节创伤是一个主要的病因学因素[1,2,4]。关节内断裂，关节位错和其他关节损伤会导致创伤后骨关节炎。尽管它们是联合创伤的子集，但ACL和半月板伤害是骨科医生治疗的最常见伤害[11，12]。尽管最近对ACL损伤的手术和非手术治疗方面取得了进步，但与没有关节损伤的患者相比，受伤后十年后，患有ACL和相关伤害的患者遭受了50％的损害膝盖功能损害的机会，OA的风险增加了十倍[13-15]。美国骨科运动医学学会（AOSSM）成立于1972年，主要是传播临床技术和新研究结果的论坛，现在是运动医学教育，研究，交流和研究生领域的世界领导者。该协会及其成员专注于对活跃人士通常遭受的伤害的治疗以及恢复积极的生活方式。 AOSSM认识到身体，情感和社会经济负担的共同负担，并在运动员，活跃的个人和整个社会上进行创伤后的OA场所。 AOSSM联合损伤骨关节炎会议II将于2010年12月2日至5日在洛杉矶新奥尔良举行，在洛兹 - 卡尔顿新奥尔良。这次会议是及时的，并且对2008年12月11日至14日举行的AOSSM/NIH R-13损伤后骨关节炎会议产生的势头进行了逻辑跟进。提议的会议将临床研究领域的领导者和专家汇集在一起，在新的临床临床评估中的专家团结一致地讨论和设计了临床临床临床的临床临床研究，以解决人类的临床临床研究，以促进人类的临床临床研究，以促进人类的ACL临床临床，以促进人类的ACL临床。结合后伤害OA。意义：建立有创伤后OA风险的个体的前瞻性临床研究人群的最终目标是促进开发新的合作方法，以改善早期疾病的修改治疗方法。成功的方法可能不仅适用于一般的关节损伤，还适用于软骨损伤和变性的早期诊断和治疗，作为减轻骨关节炎总疾病负担的策略。