AOSSM Post-joint Injury Conference II

AOSSM 关节损伤后会议 II

• 批准号: 8062988
• 负责人: CONSTANCE R CHU
• 金额: $ 2.5万
• 依托单位: AMERICAN ORTHOPAEDIC SOCIETY/SPORTS MED
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-06 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8062988
• 关键词: Acute; Address; American; Arts; Biochemical; Biological Markers; Cartilage injury; Clinical; Clinical Research; Clinical assessments; Communication Research; Degenerative polyarthritis; Development; Disease; Early Diagnosis; Education; Emotional; End stage renal failure; Fellowship; Fracture; Goals; Health; Heart failure; Image; Impairment; Individual; Injury; Joint Dislocation; Joints; Knee; Lead; Life; Life Style; Lower Extremity; Measurement; Methods; Modality; Multi-Institutional Clinical Trial; ORALIT; Orthopedics; Outcome; Patients; Recommendation; Reporting; Research; Research Design; Risk; Scientist; Site; Societies; Sports Medicine; Surgeon; Techniques; arthropathies; articular cartilage; burden of illness; cohort; design; disability; high risk; human subject; injured; joint function; joint injury; kinematics; meetings; member; prevent; programs; prospective; restoration; socioeconomics; symposium

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most common joint disease and is a leading cause of disability worldwide [1,2]. The physical impairment from OA of a single lower extremity joint is equivalent to that reported for major life-altering disorders such as end-stage kidney disease and heart failure [3]. The causes of OA are not well understood. However, joint trauma is a leading etiological factor [1,2,4]. Intra-articular fracture, joint dislocations, and other joint injuries can lead to post-traumatic osteoarthritis. Although they are a subset of joint trauma, ACL and meniscal injuries are the most common injuries treated by orthopaedic surgeons [11, 12]. Despite recent advances in operative and non-operative treatment of ACL injuries, patients sustaining ACL and related injuries suffer a 50% chance of compromised knee function ten years after injury and have a ten-fold increased risk of OA compared to those who did not have a joint injury [13-15]. Formed in 1972 primarily as a forum for dissemination of developments in clinical technique and new research findings, the American Orthopaedic Society for Sports Medicine (AOSSM) is now a world leader in sports medicine education, research, communication, and fellowship. The Society and its members focus on the treatment of injuries commonly sustained by active individuals and the restoration of active lifestyles. The AOSSM recognizes the physical, emotional, and socioeconomic burdens joint injury and post-traumatic OA places on athletes, active individuals, and society in general. The AOSSM Post-joint Injury Osteoarthritis Conference II will be held December 2-5, 2010 in New Orleans, LA at the Ritz-Carlton New Orleans. The meeting is timely, and a logical follow-on to the momentum generated from the AOSSM/NIH R-13 Post-joint Injury Osteoarthritis Conference held December 11-14, 2008. The proposed conference brings together leaders in clinical research and experts in new quantitative clinical assessment modalities together to discuss and design a multi-center clinical study of human subjects following ACL injury for the possible development of a clinical initiative addressing post-joint injury OA. SIGNIFICANCE: The ultimate goal of establishing prospective clinical study cohorts of individuals at risk for post-traumatic OA is to facilitate the development of new collaborative approaches for early disease modifying treatments. Successful approaches would be potentially more broadly applicable not only to joint injury in general and also to the early diagnosis and treatment of cartilage injury and degeneration as strategies to reduce the total disease burden of osteoarthritis.

描述（由申请人提供）：骨关节炎 (OA) 是最常见的关节疾病，也是全世界残疾的主要原因 [1,2]。单个下肢关节 OA 造成的身体损伤相当于报道的终末期肾病和心力衰竭等严重改变生活的疾病所造成的身体损伤[3]。 OA 的病因尚不清楚。然而，关节创伤是一个主要病因[1,2,4]。关节内骨折、关节脱位和其他关节损伤可导致创伤后骨关节炎。尽管 ACL 和半月板损伤是关节损伤的一部分，但它们是骨科医生治疗的最常见损伤 [11, 12]。尽管最近在 ACL 损伤的手术和非手术治疗方面取得了进展，但与未发生关节损伤的患者相比，遭受 ACL 和相关损伤的患者在受伤 10 年后膝关节功能受损的可能性为 50%，并且 OA 的风险增加了 10 倍 [13-15]。美国骨科运动医学学会 (AOSSM) 成立于 1972 年，主要作为传播临床技术发展和新研究成果的论坛，如今已成为运动医学教育、研究、交流和奖学金领域的世界领导者。该协会及其成员专注于治疗活跃个体通常遭受的伤害和恢复积极的生活方式。 AOSSM 认识到关节损伤和创伤后 OA 对运动员、活跃个人和整个社会造成的身体、情感和社会经济负担。 AOSSM 关节损伤后骨关节炎会议 II 将于 2010 年 12 月 2 日至 5 日在路易斯安那州新奥尔良新奥尔良丽思卡尔顿酒店举行。这次会议是及时的，也是 2008 年 12 月 11 日至 14 日举行的 AOSSM/NIH R-13 关节损伤后骨关节炎会议所产生势头的合理后续。拟议的会议将临床研究的领导者和新的定量临床评估模式的专家聚集在一起，讨论和设计一项针对 ACL 损伤后的人类受试者的多中心临床研究，以便可能制定一项解决以下问题的临床计划： 关节损伤后 OA。意义：建立创伤后骨关节炎风险个体的前瞻性临床研究队列的最终目标是促进早期疾病修饰治疗的新协作方法的开发。成功的方法可能不仅可以更广泛地应用于一般关节损伤，还可以应用于软骨损伤和退化的早期诊断和治疗，作为减少骨关节炎总疾病负担的策略。