AOSSM Post-joint Injury Conference II

描述(由申请人提供)：骨关节炎(OA)是最常见的关节疾病，也是全球残疾的主要原因[1，2]。单个下肢关节骨关节炎造成的身体损害相当于报道的主要改变生活的疾病，如终末期肾病和心力衰竭[3]。骨性关节炎的病因还不是很清楚。然而，关节创伤是主要的病因[1，2，4]。关节内骨折、关节脱位和其他关节损伤可导致创伤后骨关节炎。虽然它们是关节创伤的一个子集，但前交叉韧带和半月板损伤是骨科医生最常见的损伤[11，12]。尽管最近在前交叉韧带损伤的手术和非手术治疗方面取得了进展，但遭受前交叉韧带及相关损伤的患者在损伤后10年有50%的机会出现膝关节功能受损，并且与没有关节损伤的患者相比，发生骨性关节炎的风险增加了10倍[13-15]。美国运动医学整形外科学会(AOSSM)成立于1972年，最初是一个传播临床技术发展和新研究成果的论坛，现在是运动医学教育、研究、交流和研究的世界领先者。该协会及其成员侧重于治疗活跃的个人通常遭受的伤害和恢复活跃的生活方式。AOSSM认识到关节损伤和创伤后骨关节炎对运动员、活跃的个人和整个社会造成的身体、情感和社会经济负担。AOSSM关节损伤后骨关节炎会议II将于2010年12月2日至5日在洛杉矶新奥尔良丽思卡尔顿酒店举行。这次会议是及时的，也是2008年12月11日至14日举行的AOSSM/NIH R-13关节损伤后骨关节炎会议所产生的势头的合乎逻辑的后续行动。拟议的会议将临床研究的领导者和新的定量临床评估模式的专家聚集在一起，讨论和设计一项针对前交叉韧带损伤后人类受试者的多中心临床研究，以可能开发一项解决关节损伤后骨性关节炎的临床倡议。意义：建立创伤后骨性关节炎高危个体前瞻性临床研究队列的最终目标是促进早期疾病调整治疗新协作方法的发展。成功的方法不仅可能更广泛地适用于一般关节损伤，而且还可能更广泛地适用于软骨损伤和退变的早期诊断和治疗，以此作为减少骨关节炎总疾病负担的战略。

DESCRIPTION (provided by applicant): Osteoarthritis (OA) is the most common joint disease and is a leading cause of disability worldwide [1,2]. The physical impairment from OA of a single lower extremity joint is equivalent to that reported for major life-altering disorders such as end-stage kidney disease and heart failure [3]. The causes of OA are not well understood. However, joint trauma is a leading etiological factor [1,2,4]. Intra-articular fracture, joint dislocations, and other joint injuries can lead to post-traumatic osteoarthritis. Although they are a subset of joint trauma, ACL and meniscal injuries are the most common injuries treated by orthopaedic surgeons [11, 12]. Despite recent advances in operative and non-operative treatment of ACL injuries, patients sustaining ACL and related injuries suffer a 50% chance of compromised knee function ten years after injury and have a ten-fold increased risk of OA compared to those who did not have a joint injury [13-15]. Formed in 1972 primarily as a forum for dissemination of developments in clinical technique and new research findings, the American Orthopaedic Society for Sports Medicine (AOSSM) is now a world leader in sports medicine education, research, communication, and fellowship. The Society and its members focus on the treatment of injuries commonly sustained by active individuals and the restoration of active lifestyles. The AOSSM recognizes the physical, emotional, and socioeconomic burdens joint injury and post-traumatic OA places on athletes, active individuals, and society in general. The AOSSM Post-joint Injury Osteoarthritis Conference II will be held December 2-5, 2010 in New Orleans, LA at the Ritz-Carlton New Orleans. The meeting is timely, and a logical follow-on to the momentum generated from the AOSSM/NIH R-13 Post-joint Injury Osteoarthritis Conference held December 11-14, 2008. The proposed conference brings together leaders in clinical research and experts in new quantitative clinical assessment modalities together to discuss and design a multi-center clinical study of human subjects following ACL injury for the possible development of a clinical initiative addressing post-joint injury OA. SIGNIFICANCE: The ultimate goal of establishing prospective clinical study cohorts of individuals at risk for post-traumatic OA is to facilitate the development of new collaborative approaches for early disease modifying treatments. Successful approaches would be potentially more broadly applicable not only to joint injury in general and also to the early diagnosis and treatment of cartilage injury and degeneration as strategies to reduce the total disease burden of osteoarthritis.