Administrative and Protocol Management Core

这笔赠款的行政和方案管理核心（核心A）将为四个科学项目和两个题为“替诺福韦和UC 781的替代制剂”的计划的科学核心提供行政支持。具体而言，行政核心将1）提供行政监督， 本项目中的科学项目和核心，2）为所有项目和核心的项目提供财政监督和协调，3）是本研究项目与负责HIV局部杀微生物剂综合临床前/临床项目的NIAID项目官员之间的主要联系人， 4)计划和协调科学指导委员会的月度电话会议，5）建立一个由外部科学家组成的科学咨询小组，参加科学指导委员会和NIAID计划科学家的年度会议，6）协助核心C协调研究活动， 合作伙伴和康拉德。此外，该核心将为项目3和4中的临床研究提供方案管理支持，并确保拥有UC 781和替诺福韦专有权的CONRAD、匹兹堡大学IRB和艾滋病部门之间的顺利互动。该核心将由Sharon Hillier博士和丽莎罗汉博士领导，将通过促进与其他从事杀微生物剂研究的投资者的科学互动和合作，支持所有四个科学项目和两个科学核心。

The Administrafive and Protocol Management Core (Core A) of this grant will provide administrative support for the four scientific projects and two scientific cores for the program entitled, "Alternative Formulations of Tenofovir and UC781". Specifically, the Administrafive Core will 1) provide administrafive oversight of the scientific projects and cores in this program, 2) provide fiscal oversight and coordinafion for the program across all projects and cores, 3) be the primary point of contact between this research program and the NIAID Program Officer in charge ofthe Integrated Preclinical/Clinical Program for HIV Topical Microbicides, 4) plan and coordinate monthly conference calls for the Scientific Steering Committee, 5) establish a Scientific Advisory Panel of outside scientists to attend an annual meeting of the Scientific Steering Committee and NIAID program scientists, and 6) assist Core C with coordinafion of research activifies with corporate partners and CONRAD. In addition, this Core will provide protocol management support for the clinical studies in Projects 3 and 4, and ensure smooth interactions between CONRAD, which holds the proprietary rights to UC781 and tenofovir, the University of Pittsburgh IRB, and the Division of AIDS. This Core, which will be led by Drs. Sharon Hillier and Lisa Rohan, will support all four scientific projects and both scientific cores through the promotion of scientific interactions and collaborafions with other invesfigators engaged in microbicide research.