Leadership and Operations Center (LOC): Microbicide Trials Network

本申请的目的是确定杀微生物剂的领导和业务结构 试验网络(MTN)。MTN于2006年首次成立，目的是确定一种安全有效的杀微生物剂 艾滋病毒预防。从一开始，MTN的目标就是有艾滋病毒风险的关键人群，包括亚洲区的妇女。 撒哈拉非洲、青少年、孕妇和哺乳期妇女以及男男性接触者。在过去的六年里，MTN 制定了阴道和直肠杀微生物剂开发的扩展计划，具有独特和实质性的 对该领域在了解安全性、有效性、药代动力学和 与使用局部杀微生物剂有关的行为背景。自成立以来，它已经开发出一种 共有31项新协议。在这份持续申请中提出的计划是建立在这个基础上的 研究扩大在未来7年内将在1-3阶段研究中测试的活性药物组合。它是 预计这些研究将朝着2B/3期直肠杀菌剂和 联合抗逆转录病毒/荷尔蒙避孕环。尖端生物医学和行为研究 将通过生物医学和行为研究工作的贡献纳入方法 团体和社区对协议的看法将通过社区工作纳入其中 一群人。

The objective of this application is to define the leadership and operational structures for the Microbicide Trials Network (MTN). The MTN was first established in 2006 to identify a safe and effective microbicide for HIV prevention. From the outset, the MTN targeted key populations at risk of HIV including women in Sub- Saharan Africa, adolescents, pregnant and lactating women, and MSM. Over the last six years, the MTN has developed an expansive program in vaginal and rectal microbicide development, with unique and substantial contributions to the field in the understanding of the safety, effectiveness, pharmacokinetics, and the behavioral context associated with the use of topical microbicides. Since its inception, it has developed a total of 31 new protocols. The proposed plan in this continuing application is to build on this foundation of research to expand the portfolio of active agents to be tested in phase 1-3 studies over the next 7 years. It is anticipated that these studies will build toward a phase 2B/3 studies of a rectal microbicide and a combination antiretroviral/hormonal contraceptive ring. Cutting edge biomedical and behavioral research approaches will be incorporated through the contributions of the biomedical and behavioral research working groups, and community perspectives on protocols will be incorporated through the community working group.