Leadership and Operations Center (LOC): Microbicide Trials Network

本申请的目的是确定杀微生物剂的领导和运营结构 审判网。MTN最初成立于2006年，旨在确定一种安全有效的杀微生物剂， 预防艾滋病毒。从一开始，中期战略就针对艾滋病毒高危人群，包括亚热带妇女， 撒哈拉非洲，青少年，孕妇和哺乳期妇女，男男性接触者。在过去的六年里，MTN 在阴道和直肠杀微生物剂开发方面开发了一个广泛的项目， 在理解安全性、有效性、药代动力学和 与使用局部杀微生物剂相关的行为背景。自成立以来，它已经开发了一个 共有31个新协议。本持续申请中的拟议计划是在以下基础上建立： 在未来7年内，将在1-3期研究中测试的活性药物组合。是 预计这些研究将建立一个2B/3期研究的直肠杀微生物剂和 抗逆转录病毒/激素避孕环。前沿生物医学和行为研究 方法将通过生物医学和行为研究工作的贡献， 团体和社区对协议的看法将通过社区工作纳入 组

The objective of this application is to define the leadership and operational structures for the Microbicide Trials Network (MTN). The MTN was first established in 2006 to identify a safe and effective microbicide for HIV prevention. From the outset, the MTN targeted key populations at risk of HIV including women in Sub- Saharan Africa, adolescents, pregnant and lactating women, and MSM. Over the last six years, the MTN has developed an expansive program in vaginal and rectal microbicide development, with unique and substantial contributions to the field in the understanding of the safety, effectiveness, pharmacokinetics, and the behavioral context associated with the use of topical microbicides. Since its inception, it has developed a total of 31 new protocols. The proposed plan in this continuing application is to build on this foundation of research to expand the portfolio of active agents to be tested in phase 1-3 studies over the next 7 years. It is anticipated that these studies will build toward a phase 2B/3 studies of a rectal microbicide and a combination antiretroviral/hormonal contraceptive ring. Cutting edge biomedical and behavioral research approaches will be incorporated through the contributions of the biomedical and behavioral research working groups, and community perspectives on protocols will be incorporated through the community working group.