Epidemiology and transmission dynamics of MDR/XDR tuberculosis

目前的估计表明，世界上大约三分之一的人口感染了M。每年有870万人患上结核病，每年有近200万人死于结核病。结核病控制方案受到多药耐药（MDR）和广泛耐药（XDR）结核病的出现和传播的威胁，因为这些病例的治疗比药物敏感菌株的治疗更复杂、更昂贵且常常不太成功。 该计划项目的目标是开展一系列相关的跨学科研究项目，重点关注多药耐药结核病和广泛耐药结核病的出现和传播，并通过开发管理和领导核心、数据库管理和中央M.结核病隔离档案。相关研究项目包括：一项在秘鲁利马进行的与药物敏感和耐药结核病的出现和传播相关的宿主和微生物因素的队列研究;结核菌株多样性及其对MDR出现和传播的贡献;以及一项使用流行病和个体预测模型支持MDR和XDR结核病公共卫生政策和临床决策的研究。

Current estimates indicate that about a third of the world's population is infected with M. tuberculosis, 8.7 million individuals develop the disease annually, and almost 2 million die each year from the disease. Tuberculosis control programs are threatened by the emergence and transmission of multidrug resistant (MDR) and extensively drug resistant (XDR) tuberculosis since the treatment of these cases is more complex, more costly, and frequently less successful than the treatment of drug sensitive strains. The goals of this proposed Program Project are to conduct a series of linked interdisciplinary research projects focused on the emergence and transmission of multidrug and extensively drug resistant tuberculosis and to support these projects through the development of a central core for administration and leadership, database management and a central M. tuberculosis isolate archive. Linked research projects include: a cohort study of host and microbial factors associated with the emergence and transmission of drug sensitive and resistant TB in Lima, Peru; a study designed to characterize M. tuberculosis strain diversity and its contribution to the emergence and spread of MDR; and a study to use epidemic and individual predictive models to support public health policy and clinical decision making for MDR and XDR tuberculosis.