Parkinson's Disease Neuroprotection Clinical Trial: Clinical Center

帕金森病神经保护临床试验：临床中心

• 批准号: 8033814
• 负责人: JULIE H CARTER
• 金额: $ 8.59万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-15 至 2012-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8033814
• 关键词: Affect; Anti-Cholinergics; Applications Grants; Caregivers; Cephalic; Clinical; Clinical Trials; Conduct Clinical Trials; Diagnosis; Disease Progression; Dystonia; Enrollment; Family; Family Study; GDNF gene; Health Sciences; Hospitalization; Huntington Disease; Industry; Infusion procedures; Injection of therapeutic agent; Intervention; Intraventricular; Levodopa; Minority Groups; Movement Disorders; Multicenter Studies; Multicenter Trials; National Institute of Neurological Disorders and Stroke; Natural History; Neuroprotective Agents; New Agents; Oregon; Outcome; Parkinson Disease; Patients; Pharmaceutical Preparations; Pharmacologic Substance; Phase; Recruitment Activity; Research Personnel; Sampling Studies; Shunt Device; Siblings; Site; Testing; Therapy Clinical Trials; Time; Universities; caregiving; cohort; experience; neuroprotection; novel therapeutics; programs; prototype; quantum; therapy development

DESCRIPTION (provided by applicant): The next quantum step forward in the treatment of Parkinson's disease will be the development of therapies which slow the progression of the disease. Testing of new agents will require recruitment of recently diagnosed Parkinson's disease subjects and retention of them in therapeutic trials lasting five to ten years. The extensive experience of the Oregon Health & Science University Parkinson Center of Oregon in conducting clinical trials, specifically long trials in recently diagnosed subjects, supports our inclusion in a cooperative multicenter trial of neruoprotective agents for Parkinson's disease. We also propose a number of means by which we may increase enrollment of de novo subjects, including subjects from minority groups, and retain them in the study. In addition, long-term trials of neuroprotective agents in early Parkinson's disease offer a unique opportunity to study the natural history of family care giving, assess caregiver strain as an outcome variable for new therapeutics and identify potential interventions to reduce care giving strain. These studies will extend and expand the preliminary studies of family care giving in Parkinson's disease we have done in the Parkinson Study Group DATATOP cohort.

描述（由申请人提供）：帕金森病治疗的下一个量子步骤将是开发减缓疾病进展的疗法。新药物的测试将需要招募最近诊断的帕金森病受试者，并将其保留在持续5至10年的治疗试验中。俄勒冈州的俄勒冈州健康与科学大学帕金森中心在进行临床试验方面的丰富经验，特别是在最近诊断的受试者中的长期试验，支持我们纳入帕金森病神经保护剂的合作多中心试验。我们还提出了一些方法，通过这些方法我们可以增加初治受试者的入组，包括少数群体受试者，并将其保留在研究中。 此外，神经保护剂在早期帕金森病中的长期试验提供了一个独特的机会来研究家庭护理的自然史，评估护理人员的压力作为新疗法的结果变量，并确定潜在的干预措施以减少护理压力。这些研究将扩展和扩大我们在帕金森研究组DATATOP队列中所做的帕金森病家庭护理的初步研究。