Motor cortex dysfunction in migraine

偏头痛的运动皮质功能障碍

基本信息

批准号：
8131128
负责人：
Jing Xiang
金额：
$ 17.63万
依托单位：
CINCINNATI CHILDRENS HOSP MED CTR
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-09-01 至 2013-08-31
项目状态：
已结题

项目摘要

DESCRIPTION (provided by applicant): Pediatric migraine is one of the five most prevalent childhood disorders in the USA, affecting more than 6 million children and adolescents, up to 10% and 28% of each group, respectively. Recent advances in migraine research have demonstrated the cortical dysfunction plays a primary role in the cascade of migraine. To measure these functional, cortical abnormalities in the brain, magnetoencephalography (MEG) may be used to detect and localize functional brain activation with high spatial and temporal resolutions. Importantly, high-frequency brain signals (HFBS, ~2,632 Hz) have recently been found in the human brain. MEG detection of HFBS provides capability far beyond the conventional methods for revealing subtle cortical dysfunction. We hypothesize that MEG can quantitatively and noninvasively assess cortical dysfunction for children with migraine during and between migraine attacks. This hypothesis is based on the following observations: (1) Cortical dysfunction can be quantified and localized with newly developed MEG methods. (2) Increased neuromagnetic activation in 65-150 Hz has been volumetrically localized in the supplementary motor cortex in children with migraine, and (3) Abnormalities of cortical excitability in migraine have been found by using low frequency brain signals (<40 Hz) and MEG. Recent reports have shown that migraine attacks can be treated and/or prevented by normalizing cortical excitability with transcranial magnetic stimulation (TMS), medications and other methods. Building on our experience in pediatric migraine and clinical applications of MEG for more than a decade, we propose to address the following specific aims: (1) Quantify the spatial and spectral alteration of motor cortex excitability in pediatric migraine during migraine attacks with MEG; (2) Determine the spatial, spectral, frequency and temporal abnormalities of movement-evoked magnetic fields (MEFs) between migraine attacks. MEG data will be digitized at 6,000 Hz. Abnormalities of cortical excitability in migraine will be determined by analyzing neuromagnetic spectral power in 0-3,000 Hz at source levels using wavelet-based beamformer. Since MEG has mainly been used in the study of brain activities in low-frequency ranges (< 40 Hz) in migraine in adults, the study of the motor cortex excitability in pediatric migraine with neuromagnetic signals in 0-3,000 Hz is novel. Quantification of the cortical excitability with neuromagnetic spectral and frequency signatures is technically innovative. Although this proposal focuses on motor cortex, the same methodologies can be applied to evaluate other brain areas as well. If successful, abnormalities of cortical excitability can be noninvasively assessed and localized with MEG. Effective methods for treating and preventing migraine attacks may be possible by normalizing cortical excitability with TMS, medication and other methods. Given that HFBS are a new discovery and our MEG methodologies are novel, improved treatment and prevention solutions based on better understanding of the mechanisms of migraine may protect children with migraine from progressing into a chronic condition with significant disability. PUBLIC HEALTH RELEVANCE: Building on recent discoveries that cortical excitability plays a primary role in the cascade of migraine progression and that the brain generates high-frequency brain signals (~2,632 Hz), we propose to use new MEG technology to quantitatively assess cortical dysfunction during acute migraine. This will add significant depth to the scientific understanding of brain activity during migraines and, if successful, may lead to the effective treatment and prevention of migraine headaches through noninvasive normalization or maintenance of cortical excitability.

描述（由申请人提供）：小儿偏头痛是美国五种最普遍的儿童疾病之一，分别影响了600万儿童和青少年，分别为每组的10％和28％。偏头痛研究的最新进展表明，皮质功能障碍在偏头痛的级联中起主要作用。为了测量大脑中的这些功能性，皮质异常，可以使用磁脑摄影（MEG）来检测和定位具有高空间和时间分辨率的功能性脑激活。重要的是，最近在人脑中发现了高频脑信号（HFB，〜2,632 Hz）。 HFB的MEG检测提供的能力远远超出了揭示细微的皮质功能障碍的常规方法。我们假设MEG可以在偏头痛攻击期间和之间的偏头痛儿童进行定量和非侵入性评估皮质功能障碍。该假设基于以下观察结果：（1）可以通过新开发的MEG方法对皮质功能障碍进行量化和定位。（2）在偏头痛儿童中，在65-150 Hz中的神经磁激活增加了在补充运动皮层中的体积定位，并且（3）通过使用低频脑信号（<40 Hz）和MEG，已经发现了偏头痛的皮质兴奋性异常。最近的报道表明，通过通过经颅磁刺激（TMS），药物和其他方法使皮质兴奋性正常化，可以治疗和/或预防偏头痛攻击。在我们在小儿偏头痛和MEG的临床应用方面的经验基础上，我们建议解决以下特定目标：（1）量化MEG偏头痛期间小儿偏头痛的运动皮层兴奋性的空间和光谱改变；（2）确定偏头痛攻击之间运动诱发磁场（MEF）的空间，光谱，频率和时间异常。 MEG数据将以6,000 Hz数字化。偏头痛中皮质兴奋性的异常将通过使用基于小波的束式器分析0-3,000 Hz的神经磁光谱功率来确定。由于MEG主要用于研究成年人偏头痛低频范围（<40 Hz）的大脑活动，因此在0-3,000 Hz中对小儿偏头痛的运动皮质兴奋性的研究是新颖的。用神经磁性光谱和频率特征对皮质兴奋性进行定量在技术上是创新的。尽管该提案侧重于运动皮层，但也可以应用相同的方法来评估其他大脑区域。如果成功，则可以无创评估皮质兴奋性异常，并与MEG定位。通过使用TMS，药物和其他方法将皮质兴奋性归一化，可以进行治疗和预防偏头痛攻击的有效方法。鉴于HFB是一个新发现，而我们的MEG方法是新颖的，因此，基于对偏头痛机制的更好理解，可以改善治疗和预防解决方案，可以保护偏头痛儿童的慢性病患者，并具有严重的残疾状况。公共卫生相关性：基于最近发现的皮质兴奋性在偏头痛进展中起主要作用，并且大脑会产生高频脑信号（〜2,632 Hz），我们建议在急性迁移期间使用新的MEG技术来定量评估皮质功能障碍。这将为偏头痛期间对大脑活动的科学理解提供显着的深度，如果成功的话，可能会通过非侵入性归一化或维持皮质兴奋性，从而有效地治疗和预防偏头痛。

项目成果

期刊论文数量（14）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Quantitative neuromagnetic signatures of aberrant cortical excitability in pediatric chronic migraine.

DOI：
10.1186/s10194-016-0641-x
发表时间：
2016
期刊：
The journal of headache and pain
影响因子：
0
作者：
Leiken KA;Xiang J;Curry E;Fujiwara H;Rose DF;Allen JR;Kacperski JE;O'Brien HL;Kabbouche MA;Powers SW;Hershey AD
通讯作者：
Hershey AD

Spatial Heterogeneity of Cortical Excitability in Migraine Revealed by Multifrequency Neuromagnetic Signals.

多频神经磁信号揭示偏头痛皮质兴奋性的空间异质性。

DOI：
10.1016/j.jpain.2016.02.009
发表时间：
2016
期刊：
The journal of pain
影响因子：
0
作者：
Xiang,Jing;Leiken,Kimberly;Degrauw,Xinyao;Kay,Benjamin;Fujiwara,Hisako;Rose,DouglasF;Allen,JanelleR;Kacperski,JoanneE;O'Brien,HopeL;Kabbouche,MarielleA;Powers,ScottW;Hershey,AndrewD
通讯作者：
Hershey,AndrewD

Neuromagnetic high frequency spikes are a new and noninvasive biomarker for localization of epileptogenic zones.