Developmental Control of the Cell Cycle

项目摘要 确定正常细胞周期控制的机制对于我们理解 发展和肿瘤发生。在发育过程中，细胞增殖通过 通过细胞周期与生长协调进展。相反，细胞周期停滞 发生在终末分化之前，并且通常是终末分化所必需的。细胞增殖和 细胞周期停滞在发育完成后也受到高度调节：干细胞 在成体组织中，细胞周期受到严格的控制，静止细胞也是如此， 对特定刺激的反应而增殖。细胞周期控制中的任何故障 这些情况可能会产生严重的后果， 典型的癌症生长。本项目的长期目标是阐明如何 发育程序影响细胞周期进程，这一过程仍然很差， 明白在这个建议中，我们专注于基因表达机制，控制 G1-S转换，因为这是大多数细胞决定是否进入或退出细胞的时候 周期

Project Summary Determining the mechanisms of normal cell cycle control is critical for our understanding of both development and oncogenesis. During development, cell proliferation occurs by coordinating progress through the cell cycle with growth. Conversely, cell cycle arrest occurs prior to, and is often necessary for, terminal differentiation. Cell proliferation and cell cycle arrest are also highly regulated after the completion of development: stem cells in adult tissues are under tight cell cycle control, as are quiescent cells that only proliferate in response to particular stimuli. Breakdowns in cell cycle control in any of these circumstances can have drastic consequences and contribute to the deregulated growth typical of cancer. The long term objective of this project is to elucidate how developmental programs affect cell cycle progression, a process that remains poorly understood. In this proposal we focus on gene expression mechanisms that control the G1-S transition because this is when most cells decide whether to enter or to exit the cell cycle.