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Developmental Control of the Cell Cycle

细胞周期的发育控制

基本信息

批准号：
8081156
负责人：
Robert J Duronio
金额：
$ 14.8万
依托单位：
UNIV OF NORTH CAROLINA CHAPEL HILL
依托单位国家：
美国
项目类别：
财政年份：
2010
资助国家：
美国
起止时间：
2010-07-02 至 2011-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/8081156
关键词：
Acceleration Address Adult Affect Animals Apoptosis Binding Biological Biology Cell Cycle Cell Cycle Arrest Cell Cycle Progression Cell Cycle Regulation Cell Proliferation Cells Cyclin-Dependent Kinases Cyclins DNA Binding DNA biosynthesis DNA replication origin Development Diploid Cells Disease Drosophila genus E2F Transcription Factor 1 E2F1 gene Embryo Embryonic Development Event Failure Family G1 Arrest G1 Phase Gene Amplification Gene Expression Gene Targeting Genes Genetic Transcription Genome Growth Malignant Neoplasms Mediating Mitosis Modeling Molecular Normal Cell Organism Ovarian Follicle Pathway interactions Phase Phenotype Play Polyploidy Process Proliferating Proteins Proteolysis Regulation Retinoblastoma Role Series Signal Transduction Staging Stem Cell Development Stimulus Testing Tissues Transactivation Transcription Coactivator Tumor Suppression Tumor Suppressor Proteins Variant member mutant novel paralogous gene programs response transcription factor tumorigenesis ubiquitin ligase ubiquitin-protein ligase

项目摘要

Project Summary Determining the mechanisms of normal cell cycle control is critical for our understanding of both development and oncogenesis. During development, cell proliferation occurs by coordinating progress through the cell cycle with growth. Conversely, cell cycle arrest occurs prior to, and is often necessary for, terminal differentiation. Cell proliferation and cell cycle arrest are also highly regulated after the completion of development: stem cells in adult tissues are under tight cell cycle control, as are quiescent cells that only proliferate in response to particular stimuli. Breakdowns in cell cycle control in any of these circumstances can have drastic consequences and contribute to the deregulated growth typical of cancer. The long term objective of this project is to elucidate how developmental programs affect cell cycle progression, a process that remains poorly understood. In this proposal we focus on gene expression mechanisms that control the G1-S transition because this is when most cells decide whether to enter or to exit the cell cycle.

项目摘要确定正常细胞周期控制的机制对于我们理解发展和肿瘤发生。在发育过程中，细胞增殖通过通过细胞周期与生长协调进展。相反，细胞周期停滞发生在终末分化之前，并且通常是终末分化所必需的。细胞增殖和细胞周期停滞在发育完成后也受到高度调节：干细胞在成体组织中，细胞周期受到严格的控制，静止细胞也是如此，对特定刺激的反应而增殖。细胞周期控制中的任何故障这些情况可能会产生严重的后果，典型的癌症生长。本项目的长期目标是阐明如何发育程序影响细胞周期进程，这一过程仍然很差，明白在这个建议中，我们专注于基因表达机制，控制 G1-S转换，因为这是大多数细胞决定是否进入或退出细胞的时候周期