Nanowire Nanoelectronic/Cell Assemblies as Hybrid Functional Biomaterials

纳米线纳米电子/细胞组件作为混合功能生物材料

• 批准号: 7918026
• 负责人: CHARLES M LIEBER
• 金额: $ 84万
• 依托单位: HARVARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7918026
• 关键词: Address; Behavior; Biocompatible; Biocompatible Materials; Biological; Biomedical Research; Cells; Chemicals; Communication; Detection; Development; Devices; Electronics; Goals; Hybrids; Length; Medical Device; Nanostructures; Organism; Output; Prosthesis; Research; Resolution; Signal Transduction; Tissue Microarray; Tissues; Work; base; cell assembly; flexibility; information processing; intercellular communication; meetings; nanoelectronics; nanoscale; nanoscience; nanowire; tool

The central goal of this project will be to develop active interfaces between arrays of addressable nanowire electronic devices and cells to create two- and three-dimensional functional biomaterials. The nanoscale represents a natural length scale for devices used to create active interfaces to cells because biological nanostructures are the key components that define intercellular communication and signaling in living systems, yet this scale of interface is virtually uncharted research territory. The overall objectives that will be explored to address this territory and to meet the central project goal are as follows. First, limits of nanowire nanoelectronic device/cell interface functionality and sensitivity will be characterized. Communication with cells, both recording from (cell output) and stimulation of (cell input), through direct electrical mechanisms and chemical/biological signal detection/release will be developed and the corresponding detection sensitivity and spatial resolution for different modes will be elucidated. Second, addressable arrays of different types of functional nanowire devices interfaced with cellular networks will be developed and their behavior delineated. An important emphasis of this work, which exploits the unique capabilities of bottom-up versus top-down nanoscience, will be to develop (i) interfaced nanoelectronic arrays on flexible, biocompatible polymeric substrates, (ii) folded or layered nanowire/cell three-dimensional arrays using perforated polymeric substrates to enhance layer-to-layer interactions, and (iii) nanoelectronic devices projecting out of the substrate plane to enable interfacing `into' three-dimensional cellular arrays and tissue. The proposed project has the potential to impact biomedical research in substantial ways, including the establishment of powerful new tools for understanding the behavior of interacting cellular networks, the development of sophisticated, electrically-based cell/tissue interfaces for prosthetics and other medical devices, and the creation of new biomaterials with potential for diverse applications, such as in hybrid information processing.

该项目的中心目标是开发可寻址纳米线阵列之间的有源接口 电子设备和细胞来制造二维和三维功能生物材料。纳米级 代表用于创建细胞活性接口的设备的自然长度尺度，因为生物 纳米结构是定义生命系统中细胞间通讯和信号传导的关键组成部分， 然而这种规模的界面实际上是未知的研究领域。将探讨的总体目标 解决这一问题并实现中心项目目标如下。一、纳米线纳米电子学的局限性 设备/单元接口功能和灵敏度将得到表征。与细胞通讯，均记录 来自（细胞输出）和刺激（细胞输入），通过直接的电机制和化学/生物 将开发信号检测/释放以及相应的检测灵敏度和空间分辨率 将阐明不同的模式。二、不同类型功能纳米线的可寻址阵列 将开发与蜂窝网络接口的设备并描述其行为。一个重要的 这项工作的重点是利用自下而上与自上而下纳米科学的独特能力， 开发（i）在柔性、生物相容性聚合物基底上的接口纳米电子阵列，（ii）折叠或 使用穿孔聚合物基底来增强层与层之间的分层纳米线/细胞三维阵列 相互作用，以及（iii）纳米电子器件从基板平面突出以实现“进入”接口 三维细胞阵列和组织。拟议的项目有可能影响生物医学 进行实质性研究，包括建立强大的新工具来理解 相互作用的细胞网络的行为，复杂的、基于电的细胞/组织的发展 假肢和其他医疗设备的接口，以及创造具有潜力的新型生物材料 不同的应用，例如混合信息处理。