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Impact of aging on naive CD4 T cell function

Impact of aging on naive CD4 T cell function
衰老对幼稚 CD4 T 细胞功能的影响
批准号：
8134121
负责人：
SUSAN L SWAIN
金额：
$45.62万
依托单位：
UNIV OF MASSACHUSETTS MED SCH WORCESTER
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
项目状态：
已结题
起止时间：
2005-09-01 至 2015-08-31
来源：
https://reporter.nih.gov/project-details/8134121
关键词：
AblationAccelerationActivities of Daily LivingAcuteAddressAdoptive TransferAdultAffectAgeAgingAnimalsAntigensApoptosisApoptoticAppearanceAutomobile DrivingB-LymphocytesBAX geneBCL-2 ProteinBCL2L11 geneBackBindingBiological AssayBiological MarkersBloodBlood CellsBlood specimenBone MarrowCD4 Positive T LymphocytesCD8B1 geneCell AgingCell CountCell SurvivalCell modelCell physiologyCellsChimera organismComplexControl GroupsCytometryDataDefectDepressed moodDevelopmentDown-RegulationElementsEmigrationsEnsureEnzyme-Linked Immunosorbent AssayEventExhibitsExperimental DesignsFailureFeedbackFigs - dietaryFlow CytometryFluorochromeFrequenciesFutureGene TargetingGenerationsGlucocorticoid-induced apoptosisGonadal Steroid HormonesGrowth FactorHaptensHarvestHemorrhageHormonalHormonal ChangeHormonesHumanIL2RA geneImmunizationImmunoglobulin GImmunoglobulin MImpairmentIn SituIn VitroInbred BALB C MiceIndividualInfluenzaInjection of therapeutic agentInsulin-Like Growth Factor IInterleukin-2Interleukin-4Interleukin-5Interleukin-7Interphase CellInvestigationKidneyKineticsLabelLeadLearningLifeLinkLobeLongevityLymphocyteLymphopeniaMeasuresMediatingMembraneMemoryMemory B-LymphocyteMinorModelingMolecularMonitorMouse StrainsMusNeonatalOlder PopulationOperative Surgical ProceduresOutcomeOuter Mitochondrial MembraneOutputPI3K/AKTPMAIP1 genePTPRC genePaperPathway interactionsPeptide/MHC ComplexPeptidesPeripheralPersonsPhenotypePhysiologic pulsePlayPopulationProcessProductionProliferatingProtein FamilyProtein p53ProteinsProtocols documentationPublicationsPublishingRadiation ChimeraRecoveryRegulationRegulatory T-LymphocyteRelative (related person)ResistanceResourcesRestRoleRunningSamplingSerumShapesSignal PathwaySignal TransductionSomatotropinSorting - Cell MovementSpleenStaining methodStainsStem cellsStimulusStressT cell responseT memory cellT-Cell DevelopmentT-LymphocyteT-Lymphocyte SubsetsTestingThinkingThymectomyThymus GlandTimeTransgenic MiceTranslationsVaccinatedVaccinesWild Type MouseWithdrawalWorkage effectage groupage relatedagedanti agingbasebonecapsulecell agecohortcytokinedesignexpectationfeedingin vivoin vivo Modelinsightinterestloss of functionmature animalmemory CD4 T lymphocytemiddle agemutantpathogenprematurepreventpro-apoptotic proteinprogenitorpromoterreconstitutionresearch studyresponsesenescencesoundstressorthymocytevaccination strategy

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