2011 Red Cells Gordon Research Conference

2011 红细胞戈登研究会议

• 批准号: 8198121
• 负责人: Velia M Fowler
• 金额: $ 1.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8198121
• 关键词: Academy; American Society of Hematology; Anemia; Area; Basic Science; Blood Cells; Cell Maturation; Cell Membrane Structures; Childhood; Clinical; Collaborations; Complement; Country; Defect; Development; Developmental Biology; Developmental Process; Diagnosis; Diamond-Blackfan anemia; Disabled Persons; Discipline; Disease; Epigenetic Process; Erythrocytes; Erythroid; Erythroid Cells; Erythropoiesis; Ethnic Origin; Funding; Funding Applicant; Future; Gender; Gene Expression; Genetic; Genetic Research; Genomics; Goals; Growth; Hematological Disease; Hematology; Heme; Heme Iron; Hemoglobin; Hereditary Disease; Human; Institutes; International; Iron; Lead; Life; Malaria; Membrane; Membrane Proteins; Membrane Structure and Function; Metabolism; Methodology; Minority; Mission; Molecular; Molecular Biology; National Heart, Lung, and Blood Institute; National Human Genome Research Institute; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; New Hampshire; Parasites; Participant; Pathology; Postdoctoral Fellow; Process; Production; Property; Recording of previous events; Regulation; Research; Research Personnel; Scientist; Series; Sickle Cell Anemia; Signal Transduction; Specialist; Staging; Stem cells; Students; Systems Biology; Thalassemia; Transcriptional Regulation; Transfusion; United States National Institutes of Health; Variant; Woman; Work; career; genome wide association study; graduate student; human disease; improved; innovation; insight; iron metabolism; meetings; novel; posters; progenitor; programs; protein structure; symposium; trafficking

DESCRIPTION (provided by applicant): Funds are requested for partial support of the 2011 Gordon Research Conference (GRC) on Red Cells, the next in a series of meetings that have been held every other year since 1979. This conference assembles the top established and the most promising new investigators who are working on all aspects of erythroid cells, from the developmental/environmental control of its ontogeny, to cellular/morphogenic aspects related to its unique membrane structure, to transcriptional/epigenetic regulation of its gene expression, and to disorders following from variations in these normal processes. Sessions in 2011 will include Developmental Biology of Erythropoiesis; Transcriptional Control of Gene Expression; Epigenetics and Systems Biology of Red Cells; Erythropoiesis, Signaling and Red Cell Production; Erythrocyte Terminal Maturation; Membrane Protein Structures, Associations and Functions; Red Cell Disorders; Iron, Heme and the Red Cell; Parasite Interactions with Red Cells. By focusing on these topics, the Red Cells GRC continues to be the primary venue for presentation of the latest cutting edge basic science, novel insights into human disease, and innovations in methodology that it has covered throughout its history and for which it has become famous. The meeting attracts an international coterie of researchers and provides a lively forum for active participation and discussion within intimate surroundings that facilitates interactions between senior and junior investigators, and between investigators that normally may not readily interact. The meeting will be held on July 24-29, 2011 at Proctor Academy in Andover, New Hampshire, and will convene 52 speakers with a total of ~140 participants. The conference aims to be inclusive for women, minorities, and persons with disabilities; participants will include postdoctoral fellows and graduate students in addition to investigators who are early in their academic careers. Some postdoctoral fellow and student poster presenters will be selected for short talks. The opportunities for informal gatherings at meals and in the afternoons and evenings, provides an avenue for scientists from different disciplines to interact, promoting cross-disciplinary collaboration. By the nature of its subject matter, the Red Cells GRC remains fully relevant to enhancing the understanding of both the normal progression of erythroid cell maturation and the alterations that lead to its pathology. PUBLIC HEALTH RELEVANCE: Defects in red blood cell formation and function can lead to anemias that range from mild to life-threatening. The 2011 Red Cells Gordon Research Conference is the primary means for investigators in the field to present their most recent findings, exchange ideas, and discuss future directions for investigating and understanding normal and aberrant modes of the erythroid cell. This exchange of new findings and ideas will accelerate development of improved diagnoses and therapies for human anemias.

描述（由申请人提供）：资金要求部分支持2011年戈登红细胞研究会议（GRC），自1979年以来每隔一年举行的一系列会议中的下一个。本次会议汇集了顶级和最有前途的新研究人员，他们正在研究红系细胞的各个方面，从其个体发育的发育/环境控制，到与其独特的膜结构相关的细胞/形态发生方面，到其基因表达的转录/表观遗传调控，以及这些正常过程中的变化引起的疾病。2011年的会议将包括红细胞生成的发育生物学;基因表达的转录控制;红细胞的表观遗传学和系统生物学;红细胞生成、信号传导和红细胞产生;红细胞终末成熟;膜蛋白结构、关联和功能;红细胞疾病;铁、血红素和红细胞;寄生虫与红细胞的相互作用。通过专注于这些主题，红细胞GRC仍然是展示最新前沿基础科学的主要场所，对人类疾病的新颖见解，以及它在其历史上所涵盖的方法创新，并因此而闻名。会议吸引了国际研究人员的小圈子，并提供了一个活跃的论坛，在亲密的环境中积极参与和讨论，促进高级和初级研究人员之间的互动，以及通常可能不容易互动的研究人员之间的互动。会议将于2011年7月24日至29日在新罕布什尔州安多弗的普罗克特学院举行，将召集52名演讲者，共约140名与会者。会议旨在包容妇女，少数民族和残疾人;与会者将包括博士后研究员和研究生，以及学术生涯早期的研究人员。一些博士后研究员和学生海报主持人将被选中进行简短的演讲。在用餐和下午和晚上的非正式聚会的机会，为来自不同学科的科学家提供了一个互动的途径，促进跨学科的合作。由于其主题的性质，红细胞GRC仍然与增强对红系细胞成熟的正常进展和导致其病理学的改变的理解完全相关。 公共卫生相关性：红细胞形成和功能缺陷可导致轻度至危及生命的贫血。2011年红细胞戈登研究会议是该领域研究人员展示其最新发现，交流思想和讨论未来研究方向的主要手段，并了解红细胞的正常和异常模式。这种新发现和想法的交流将加速人类贫血症诊断和治疗的改进。