2011 Red Cells Gordon Research Conference

2011 红细胞戈登研究会议

• 批准号: 8198121
• 负责人: Velia M Fowler
• 金额: $ 1.3万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8198121
• 关键词: Academy; American Society of Hematology; Anemia; Area; Basic Science; Blood Cells; Cell Maturation; Cell Membrane Structures; Childhood; Clinical; Collaborations; Complement; Country; Defect; Development; Developmental Biology; Developmental Process; Diagnosis; Diamond-Blackfan anemia; Disabled Persons; Discipline; Disease; Epigenetic Process; Erythrocytes; Erythroid; Erythroid Cells; Erythropoiesis; Ethnic Origin; Funding; Funding Applicant; Future; Gender; Gene Expression; Genetic; Genetic Research; Genomics; Goals; Growth; Hematological Disease; Hematology; Heme; Heme Iron; Hemoglobin; Hereditary Disease; Human; Institutes; International; Iron; Lead; Life; Malaria; Membrane; Membrane Proteins; Membrane Structure and Function; Metabolism; Methodology; Minority; Mission; Molecular; Molecular Biology; National Heart, Lung, and Blood Institute; National Human Genome Research Institute; National Institute of Allergy and Infectious Disease; National Institute of Child Health and Human Development; National Institute of Diabetes and Digestive and Kidney Diseases; Nature; New Hampshire; Parasites; Participant; Pathology; Postdoctoral Fellow; Process; Production; Property; Recording of previous events; Regulation; Research; Research Personnel; Scientist; Series; Sickle Cell Anemia; Signal Transduction; Specialist; Staging; Stem cells; Students; Systems Biology; Thalassemia; Transcriptional Regulation; Transfusion; United States National Institutes of Health; Variant; Woman; Work; career; genome wide association study; graduate student; human disease; improved; innovation; insight; iron metabolism; meetings; novel; posters; progenitor; programs; protein structure; symposium; trafficking

DESCRIPTION (provided by applicant): Funds are requested for partial support of the 2011 Gordon Research Conference (GRC) on Red Cells, the next in a series of meetings that have been held every other year since 1979. This conference assembles the top established and the most promising new investigators who are working on all aspects of erythroid cells, from the developmental/environmental control of its ontogeny, to cellular/morphogenic aspects related to its unique membrane structure, to transcriptional/epigenetic regulation of its gene expression, and to disorders following from variations in these normal processes. Sessions in 2011 will include Developmental Biology of Erythropoiesis; Transcriptional Control of Gene Expression; Epigenetics and Systems Biology of Red Cells; Erythropoiesis, Signaling and Red Cell Production; Erythrocyte Terminal Maturation; Membrane Protein Structures, Associations and Functions; Red Cell Disorders; Iron, Heme and the Red Cell; Parasite Interactions with Red Cells. By focusing on these topics, the Red Cells GRC continues to be the primary venue for presentation of the latest cutting edge basic science, novel insights into human disease, and innovations in methodology that it has covered throughout its history and for which it has become famous. The meeting attracts an international coterie of researchers and provides a lively forum for active participation and discussion within intimate surroundings that facilitates interactions between senior and junior investigators, and between investigators that normally may not readily interact. The meeting will be held on July 24-29, 2011 at Proctor Academy in Andover, New Hampshire, and will convene 52 speakers with a total of ~140 participants. The conference aims to be inclusive for women, minorities, and persons with disabilities; participants will include postdoctoral fellows and graduate students in addition to investigators who are early in their academic careers. Some postdoctoral fellow and student poster presenters will be selected for short talks. The opportunities for informal gatherings at meals and in the afternoons and evenings, provides an avenue for scientists from different disciplines to interact, promoting cross-disciplinary collaboration. By the nature of its subject matter, the Red Cells GRC remains fully relevant to enhancing the understanding of both the normal progression of erythroid cell maturation and the alterations that lead to its pathology. PUBLIC HEALTH RELEVANCE: Defects in red blood cell formation and function can lead to anemias that range from mild to life-threatening. The 2011 Red Cells Gordon Research Conference is the primary means for investigators in the field to present their most recent findings, exchange ideas, and discuss future directions for investigating and understanding normal and aberrant modes of the erythroid cell. This exchange of new findings and ideas will accelerate development of improved diagnoses and therapies for human anemias.

描述（由申请人提供）：要求为 2011 年戈登红细胞研究会议 (GRC) 的部分支持提供资金，这是自 1979 年以来每隔一年举行的一系列会议中的下一次会议。这次会议聚集了顶尖的和最有前途的新研究人员，他们正在研究红细胞的各个方面，从其个体发育的发育/环境控制，到与其独特的膜结构相关的细胞/形态发生方面，到 其基因表达的转录/表观遗传调控，以及这些正常过程变化引起的疾病。 2011 年的会议将包括红细胞生成发育生物学；基因表达的转录控制；红细胞表观遗传学和系统生物学；红细胞生成、信号传导和红细胞生成；红细胞终末成熟；膜蛋白结构、关联和功能；红细胞疾病；铁、血红素和红细胞；寄生虫与红细胞的相互作用。通过专注于这些主题，红细胞 GRC 继续成为展示最新前沿基础科学、对人类疾病的新颖见解以及方法创新的主要场所，这些内容在其历史上一直涵盖并因此而闻名。这次会议吸引了国际研究人员，并为在亲密的环境中积极参与和讨论提供了一个活跃的论坛，促进了高级和初级研究人员之间以及通常不易互动的研究人员之间的互动。该会议将于 2011 年 7 月 24 日至 29 日在新罕布什尔州安多弗的普罗克特学院举行，将有 52 名演讲者，总共约 140 名与会者。会议旨在包容妇女、少数族裔和残疾人；除了处于学术生涯早期的研究人员之外，参与者还将包括博士后研究员和研究生。一些博士后研究员和学生海报展示者将被选中进行简短的演讲。用餐时以及下午和晚上的非正式聚会为来自不同学科的科学家提供了互动的途径，促进了跨学科合作。就其主题的性质而言，红细胞 GRC 仍然与增强对红细胞成熟的正常进展和导致其病理学的改变的理解完全相关。 公众健康相关性：红细胞形成和功能缺陷可导致贫血，贫血程度从轻度到危及生命。 2011 年红细胞戈登研究会议是该领域的研究人员展示其最新发现、交流想法以及讨论研究和理解红细胞正常和异常模式的未来方向的主要途径。这种新发现和想法的交流将加速改进人类贫血诊断和治疗的开发。