FASEB SRC on Genetic Recombination and Genome Rearrangements

FASEB SRC 关于基因重组和基因组重排

• 批准号: 8199893
• 负责人: John HJ Petrini
• 金额: $ 0.45万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2012-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8199893
• 关键词: American; Arabidopsis; Ataxia Telangiectasia; BRCA1 gene; BRCA2 Protein; BRCA2 gene; Bacteria; Biological; Biological Models; Biology; Bloom Syndrome; Caenorhabditis elegans; Chromosomes; Colorado; DNA Repair; DNA Sequence Rearrangement; Defect; Disease; Double Strand Break Repair; Drosophila genus; Equilibrium; Genetic; Genetic Recombination; Genome; Genome Stability; Goals; Hereditary Breast Carcinoma; Human; Information Technology; Inherited; Life; Malignant Neoplasms; Mammals; Mutate; Nijmegen Breakage Syndrome; Organism; Participant; Pathway interactions; Play; Principal Investigator; Proteins; Research Personnel; Resistance; Role; Series; Societies; Syndrome; System; Techniques; Work; Xenopus; Yeasts; biological systems; environmental mutagens; homologous recombination; malignant breast neoplasm; new technology; programs; recombinational repair; symposium; unpublished works

DESCRIPTION (provided by applicant): This application seeks partial support for the Federation of American Societies of Experimental Biology (FASEB) conference on Genetic Recombination and Genome Rearrangements to be held July 24-29, 2011 in Steamboat Springs, Colorado. The 2011 Conference on Genetic Recombination and Chromosome Rearrangements will be the fourteenth in a series of highly successful bi-annual conferences devoted to these topics. This conference aims to join investigators studying many diverse aspects of genetic recombination, in a range of biological systems and with different experimental approaches. Presentations will introduce new and unpublished work on timely questions in the field and will include discussion from all participants. The FASEB conference provides unique opportunities for the exchange of information and technology that can be appreciated and exploited across the recombination field. Recombination plays an important role in the control of genetic stability in human as well as all other living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), Nijmegen Breakage Syndrome (NBS) and A-T like disorder (A-TLD), are caused by defects in double-strand break repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. Furthermore, the product of the BRCA2 gene, which is mutated in a subset of hereditary breast cancers, interacts directly with Rad51 and is essential for homologous recombination. Many of the invited speakers will discuss the role of proteins defective in these human cancer prone syndromes in genome stability and resistance to environmental mutagens. To inform and augment studies from mammals, work concerning related proteins and mechanisms from model systems of bacteria, yeast, Arabidopsis, Drosophila, C. elegans and Xenopus will be featured. Much of the conference will be devoted to topics of concern to the National Cancer. PUBLIC HEALTH RELEVANCE: DNA repair by homologous recombination plays an important role in the control of genetic stability in all living organisms. The discovery that several human cancer prone syndromes, for example, Ataxia Telangiectasia (A-T), hereditary forms of breast cancer (BRCA1 or BRCA2) and Bloom's syndrome are caused by defects in the DNA recombination/repair has highlighted the importance of this pathway in maintaining genome integrity and cancer avoidance. This conference brings together the principal investigators studying the mechanisms of recombination with the goal of further understanding how recombination contributes to genome stability.

描述（由申请人提供）：本申请为美国实验生物学联合会（FASEB）基因重组和基因组重排会议寻求部分支持，将于2011年7月24日至29日在科罗拉多州的Steamboat Springs举行。 2011年关于遗传重组和染色体重排的会议将是一系列致力于这些主题的非常成功的两年一次会议中的第十四届会议。该会议旨在加入研究人员，研究遗传重组的许多不同方面，在一系列生物系统和不同的实验方法中。演讲将在该领域及时介绍及时的问题，并包括所有参与者的讨论。 FASEB会议为信息和技术的交换提供了独特的机会，这些机会可以在整个重组领域得到赞赏和利用。 重组在控制人类以及所有其他生物体的遗传稳定性中起着重要作用。发现多种人类癌症综合症，例如，毛细血管理（A-T），Nijmegen Breakage综合征（NBS）和A-T类似疾病（A-TLD）是由双链破裂修复中的缺陷引起的，这突显了这种途径在维持天性和癌症中的重要性。此外，在遗传性乳腺癌的子集中突变的BRCA2基因的产物直接与RAD51相互作用，对于同源重组至关重要。许多受邀的扬声器将讨论蛋白质在这些易于人类癌症综合症中有缺陷的蛋白质在基因组稳定性和对环境诱变剂的抗性中的作用。为了告知和增强哺乳动物的研究，将介绍有关细菌，酵母，拟南芥，果蝇，秀丽隐杆线虫和Xenopus的相关蛋白质和机制的工作。会议的大部分时间将致力于全国癌症关注的主题。 公共卫生相关性：通过同源重组维修的DNA修复在控制所有生物体的遗传稳定性中起重要作用。发现一些人类癌症易于综合症的发现，例如毛细血管理（A-T），遗传形式的乳腺癌（BRCA1或BRCA2）和Bloom综合征是由DNA重组/修复中的缺陷引起的，这突显了这一途径在维持天性综合和避免癌症方面的重要性。这次会议汇集了研究重组机制的主要研究人员，目的是进一步了解重组如何有助于基因组稳定性。