2011 Polyamines Gordon Research Conference and Gordon Research Seminar

2011年多胺戈登研究会议暨戈登研究研讨会

• 批准号: 8118329
• 负责人: LISA M SHANTZ
• 金额: $ 0.2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8118329
• 关键词: Antineoplastic Agents; Antiparasitic Agents; Area; Award; Bacteria; Bacterial Infections; Basic Science; Cell physiology; Collaborations; Communities; Creativeness; Development; Discipline; Disease; Disease model; Energy Metabolism; Environment; Enzymes; Epigenetic Process; Eukaryota; Eukaryotic Cell; Fostering; Funding; Genetic; Goals; Growth; Homeostasis; International; Link; Location; Malignant Neoplasms; Mammalian Cell; Metabolic Pathway; Metabolism; Organism; Parasites; Parasitic infection; Participant; Pathogenesis; Pathway interactions; Physiological; Play; Polyamines; Postdoctoral Fellow; Prokaryotic Cells; Protozoa; Request for Proposals; Research; Research Personnel; Resort; Role; Scientist; Students; Therapeutic; Therapeutic Agents; Translational Research; Travel; Work; Yeasts; analog; cancer chemoprevention; carcinogenesis; cell growth; design; drug development; experience; graduate student; human disease; insight; interest; meetings; multidisciplinary; planetary Atmosphere; polycation; posters; small molecule; success; symposium; tool; tumor

DESCRIPTION (provided by applicant): Since 1975, the Gordon Research Conference (GRC) on Polyamines has been a multidisciplinary conference focused on the polyamine metabolic pathway, the role of polyamines in cellular physiology and the development of small molecules that modulate polyamine metabolism as potential therapeutic agents. This meeting is widely regarded as the pre-eminent venue for the presentation and discussion of polyamine research. The Polyamines GRC will be held at the Waterville Valley Resort in Waterville Valley, NH from June 19-24, 2011. Polyamines are small organic polycations found in virtually all prokaryotic and eukaryotic cells. It has been acknowledged for many years that the polyamines and their enzymes play critical roles in a diverse set of human diseases. In recent years, it has become increasingly clear that polyamines have unique roles in different organisms, and further that the biosynthetic and catabolic pathways, as well as the associated regulatory mechanisms, vary widely among species. Thus, the field brings together researchers interested in the physiological role of polyamines in a broad array of organisms (mammalian cells, yeast, protozoa and bacteria) and researchers interested in therapeutic applications for cancer and parasitic or bacterial infection. This variety of scientific disciplines represented at the Polyamines GRC makes for an intellectually stimulating environment for participants. The 2011 conference will feature presentations from scientists in the forefront of polyamine research. Speakers will emphasize the role of the polyamines in carcinogenesis, diseases of energy metabolism and parasite pathogenesis. The meeting will include presentations on anticancer and antiparasitic drug development, as well as disease models to bridge the gap between basic and translational research. Other sessions have been designed to promote discussion in the area of epigenetics, which may give insight into the basic mechanisms by which polyamines regulate cell growth, and to outline the role of polyamine metabolism in cellular homeostasis in a variety of organisms. The meeting will be composed of 30 minute talks followed by 10 minute discussion periods, and two poster sessions. It will also include short talks by students or postdoctoral fellows whose work has been chosen from the poster presentations. To further encourage the participation of young scientists, the Polyamines GRC will be held in conjunction with the third Graduate Research Seminar (GRS) on Polyamines. The main objective of the GRS will again be to provide graduate students and postdoctoral fellows with a relaxed atmosphere that encourages free exchange of scientific information in the absence of all but a few senior colleagues. In previous years this has made the GRC that follows a richer and less intimidating experience, as evidenced by significant participation of these young scientists in discussion periods during the main conference. We anticipate that the interactions between participants of both conferences will promote the sharing of research tools and ideas, consequently strengthening current collaborations and fostering new ones. PUBLIC HEALTH RELEVANCE: PROJECT NARRATIVE The Gordon Research Conference on Polyamines and the pre-conference Graduate Research Seminar provide a forum for both internationally known researchers and young scientists new to the field to discuss their work and maintain active scientific collaborations. Our goal is to promote discussion from a diverse scientific community on the mechanisms that link the polyamines and their enzymes to human disease. The Gordon Conferences provide the ideal setting, with a format emphasizing the presentation of new and unpublished material in an informal and interactive setting that encourages extensive discussion.

描述(申请人提供)：自1975年以来，戈登多胺研究会议(GRC)一直是一个多学科的会议，重点是多胺代谢途径，多胺在细胞生理学中的作用，以及作为潜在治疗剂调节多胺代谢的小分子的发展。这次会议被广泛认为是介绍和讨论多胺研究的最好场所。多胺GRC将于2011年6月19日至24日在华盛顿州沃特维尔山谷的沃特维尔山谷度假村举行。多胺是一种小的有机聚阳离子，几乎存在于所有原核和真核细胞中。多胺及其酶在一系列不同的人类疾病中起着关键作用，这一点多年来已被公认。近年来，人们越来越清楚地认识到，多胺在不同的生物体中具有独特的作用，而且不同物种的生物合成和分解代谢途径以及相关的调节机制也存在很大差异。因此，该领域聚集了对多胺在一系列生物体(哺乳动物细胞、酵母、原生动物和细菌)中的生理作用感兴趣的研究人员和对癌症和寄生虫或细菌感染的治疗应用感兴趣的研究人员。在多胺GRC上代表的各种科学学科为参与者创造了一个激发智力的环境。2011年的会议将由多胺研究前沿的科学家发表演讲。演讲者将强调多胺在癌症发生、能量代谢疾病和寄生虫致病中的作用。会议将包括关于抗癌和抗寄生虫药物开发的演讲，以及弥合基础研究和转化性研究之间差距的疾病模型。其他会议的目的是促进表观遗传学领域的讨论，这可能使人们深入了解多胺调节细胞生长的基本机制，并概述多胺代谢在各种生物体的细胞内稳态中的作用。会议将由30分钟的演讲、10分钟的讨论时间和两个海报会议组成。它还将包括学生或博士后研究员的简短演讲，他们的作品是从海报演示中挑选出来的。为了进一步鼓励年轻科学家的参与，多胺GRC将与第三届多胺研究生研究研讨会(GRS)同时举行。GRS的主要目标将再次是为研究生和博士后研究员提供一个宽松的氛围，鼓励在除少数资深同事以外的所有人缺席的情况下自由交流科学信息。在前几年，这使得GRC有了更丰富和不那么可怕的经历，这些年轻科学家在主要会议期间大量参与讨论就是明证。我们预计，两次会议与会者之间的互动将促进研究工具和想法的共享，从而加强目前的合作并促进新的合作。 公共卫生相关性：项目说明戈登多胺研究会议和会前研究生研究研讨会为国际知名的研究人员和新进入该领域的年轻科学家提供了一个论坛，讨论他们的工作并保持积极的科学合作。我们的目标是促进不同科学界对多胺及其酶与人类疾病联系机制的讨论。戈登会议提供了理想的环境，其形式强调在鼓励广泛讨论的非正式和互动环境中介绍新的和未出版的材料。