FASEB SRC on Signal Transduction in the Immune System

描述（由申请人提供）：本申请寻求FASEB夏季会议“免疫系统中的信号转导”的部分资金，将于2011年6月19日至24日在科罗拉多州斯诺马斯举行，未来的会议将于2013年和2015年举行。本次会议的主要目标是全面关注有关健康和疾病中免疫细胞反应的信号机制的最新进展。2011年的会议将是FASEB会议的第六次会议。这次会议已经在研究机构，学术界和工业界引起了广泛的兴趣，因为杰出的发言者名单，所提出的工作的前沿性和许多演讲与免疫疾病的相关性。此外，由于大多数主流免疫学会议不提供信号转导机制的深入关注，这个专门的FASEB会议已经建立了会议作为许多研究人员的高调论坛。因此，本次FASEB会议是FASEB夏季会议中出席人数最多的会议之一。会议吸引了世界各地免疫信号转导的领导者，以及新的研究人员和学生。计划于2011年举行的会议包括对适应性和先天免疫信号机制的共同重视，使该计划在免疫学会议中独一无二，特别是在专注于信号的会议中。2011年的会议包括一个强烈的关注细胞骨架的变化，调节白细胞活化和迁移，在淋巴细胞分化过程中的代谢途径的重要性，并使用显微镜和数学建模，以揭示白细胞受体信号和激酶调节的详细生化机制。这些主题代表了免疫信号研究的前沿，并使拟议的计划相对于其他会议独特。虽然会议有一个骨干的定期与会者和发言者，我们将确保新的想法和领域是在2011年提出了22个新的发言者（共33个邀请会谈）。此外，每次会议都有空间从摘要中选择一个或几个简短的演讲，优先考虑新的研究者或来自PI未发表的小组的博士后。这将确保会议议题的多样性。会议的总体目标是：1.提供一个关键的和密集的概述免疫信号的最新进展，强调白细胞迁移和代谢和使用尖端技术来解决这些问题; 2。将资深科学家和年轻研究人员聚集在一起，在轻松愉快的气氛中进行演讲和非正式讨论，以提高学生和年轻研究人员的技能; 3.通过广泛传播信息和最新突破，快速推进免疫系统分子机制的研究。因此，我们预计这次会议将建立在过去的会议在影响免疫信号研究的方向的成功。 公共卫生相关性：本次会议的主要目标是全面关注有关健康和疾病中免疫细胞反应的信号机制的最新进展。大量人类疾病影响信号转导途径中的分子，因此，这些途径为越来越多的涉及免疫系统和炎症的疾病提供了潜在的治疗靶点。本次会议将通过广泛传播该领域的信息和最新突破，为免疫系统研究的快速发展做出贡献。此外，本次会议将提供一个论坛，热烈讨论新的想法及其对治疗炎症和自身免疫性疾病以及癌症的新型疗法开发的适用性。

DESCRIPTION (provided by applicant): This application seeks partial funding for a FASEB Summer Conference on "Signal Transduction in the Immune System", to be held June 19-24, 2011 in Snowmass, Colorado, with future meetings to be held in 2013 and 2015. The major goal of this conference is to provide a comprehensive focus on recent advances regarding the signaling mechanisms involved in the response of immune cells in both health and disease. The meeting in 2011 will be the 6th occurrence of this FASEB conference. This conference has garnered widespread interest in research institutes, academia, and industry because of the outstanding speaker rosters, the cutting edge nature of the work presented and the relevance of many presentations to immunologic diseases. Additionally, since most mainstream immunology meetings do not provide an in-depth focus on signal transduction mechanisms, this dedicated FASEB conference has established the meeting as a high profile forum for many investigators. As a result, this FASEB conference has been one of the most highly attended FASEB Summer conferences in general. The meeting attracts the leaders in immune signal transduction world-wide, as well as new investigators and students. The meeting planned for 2011 includes a joint emphasis on adaptive and innate immune signaling mechanisms, making this program unique among immunology meetings, and in particular, among meetings focusing on signaling. The 2011 conference includes a strong focus on cytoskeletal changes that regulate leukocyte activation and migration, the importance of metabolic pathways during lymphocyte differentiation, and the use of microscopy and mathematical modeling to uncover detailed biochemical mechanisms of leukocyte receptor signaling and kinase regulation. These topics represent the cutting edge of research in immune signaling, and make the proposed program unique relative to other meetings. Though the conference has a backbone of regular attendees and speakers, we will ensure that new ideas and areas are addressed in 2011 by featuring 22 new speakers (out of a total of 33 invited talks). In addition, each session has space for one or several short talks to be selected from abstracts, with priority given to new investigators or post-docs from groups in which PIs are not presenting. This will ensure a diversity of topics at the meeting. The overall objectives of the meeting are: 1. To provide a critical and intensive overview of the recent advances in immune signaling, emphasizing leukocyte migration and metabolism and the use of cutting edge technologies to address these issues; 2. To bring together senior scientists and young investigators in a convivial atmosphere of presentation and informal discussion to promote the skills of students and young investigators; 3. To rapidly advance the research on the molecular mechanisms in the immune system by broadly disseminating information and recent breakthroughs. Thus, we anticipate that this conference will build upon the success of past conferences in influencing the direction of immune signaling research. PUBLIC HEALTH RELEVANCE: The major goal of this conference is to provide a comprehensive focus on recent advances regarding the signaling mechanisms involved in the response of immune cells in both health and disease. A large number of human diseases affect molecules in signal transduction pathways and thus, these pathways present potential therapeutic targets for the increasing number of diseases involving the immune system and inflammation. This conference will contribute to the rapid advancement of research on the immune system by broadly disseminating information and recent breakthroughs in the field. In addition, this conference will provide a forum for lively discussions of new ideas and their applicability to the development of novel therapeutics to treat inflammatory and autoimmune disorders, as well as cancer.