2011 Gordon Research Conference: Cellular and Molecular Mechanisms of Toxicity

描述（由申请人提供）：2011 GRC-CMMOT：了解后基因组时代的创新机制毒理学摘要：基础分子毒理学继续支持环境，制药和工业科学的关键创新。全球对药物和环境接触的监管以及公众对风险的看法正在发生很大变化。为了应对这些挑战，这一领域的发展科学需要保持领先的监管，政治和立法。因此，本次会议将介绍尖端的机制毒理学研究，支持环境，制药和工业科学的关键创新，并预示着一个令人兴奋的时期，在寻求预测和规避药物和毒物不良反应。会议将讨论广泛的主题，如炎症和修复/适应，时钟基因，表观基因组学，肝毒性，神经炎性疾病，个体易感性/适应以及计算机和体内预测毒理学的新模型。会议将汇集在各自领域前沿的研究人员，并将为年轻科学家和研究生提供机会，以海报形式展示他们的工作，并与该领域的领导人交流思想。一些海报主持人将被选中进行简短的演讲。本次会议的合议气氛，与程序化的讨论会，以及在下午和晚上的非正式聚会的机会，为来自不同学科的科学家提供了一个渠道，集思广益，并促进跨学科的合作，在各个研究领域的代表。 公共卫生相关性：2011年GRC：在过去的几年里，人们越来越关注环境暴露及其对人类健康的潜在影响，从哮喘到癌症。这次关于毒性的细胞和分子机制的会议重点关注暴露评估的前沿进展以及我们对与环境相关的人类疾病起源的关键细胞和分子事件的理解的最新进展。拟议的会议将为那些领导各自研究领域的人提供一个独特的机会，分享他们的成果，讨论未来的方向，并建立合作努力，以推进这一高度跨学科的科学领域。

DESCRIPTION (provided by applicant): 2011 GRC-CMMOT: Understanding Innovative Mechanistic Toxicology in the Post-Genomic Era Abstract: Basic molecular toxicology continues to underpin key innovations in environmental, pharmaceutical and industrial sciences. Much is changing in global regulation of pharmaceutical and environmental exposures and also in public perception of risk. In order to meet these challenges, the developing science in this area needs to keep ahead of regulation, politics and legislation. Thus, this conference will present cutting edge mechanistic toxicological research underpinning key innovations in environmental, pharmaceutical and industrial sciences and heralds an exciting period in the quest to predict and circumvent adverse drug and toxicant reactions. The Conference will feature a wide range of topics, such as inflammation and repair/adaptation, clock genes, epigenomics, hepatotoxicity, neuroinflammatory diseases, individual susceptibility/adaptation together with new models of in silico and in vivo predictive toxicology. The Conference will bring together a collection of investigators who are at the forefront of their field, and will provide opportunities for junior scientists and graduate students to present their work in poster format and exchange ideas with leaders in the field. Some poster presenters will be selected for short talks. The collegial atmosphere of this Conference, with programmed discussion sessions as well as opportunities for informal gatherings in the afternoons and evenings, provides an avenue for scientists from different disciplines to brainstorm and promotes cross-disciplinary collaborations in the various research areas represented. PUBLIC HEALTH RELEVANCE: 2011 GRC: CMMOT Narrative Over the past several years, there has been growing concern regarding environmental exposures and their potential impact on human health, from asthma to cancer. This conference on the cellular and molecular mechanisms of toxicity focuses on both cutting-edge advances in exposure assessment as well as the latest advancements in our understanding of key cellular and molecular events underlying the origins of environmentally-linked human disease. The proposed conference will represent a unique opportunity for those leading their respective research areas to share their results, discuss future directions, and forge collaborative efforts that would advance this highly interdisciplinary field of science.