2011 Fibronectin, Integrins and Related Molecules GRC/GRS

2011 纤连蛋白、整合素及相关分子 GRC/GRS

• 批准号: 8125512
• 负责人: DAVID A CALDERWOOD
• 金额: $ 0.6万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-28 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8125512
• 关键词: Address; Adhesions; Area; Atherosclerosis; Blood Platelets; Cardiovascular Diseases; Cardiovascular system; Cell Adhesion; Cell Adhesion Process; Cell-Cell Adhesion; Cells; Cellular Morphology; Disease; Disease model; Distant; Education; Embryonic Development; Event; Extracellular Matrix; Fibronectins; Government; Health; Homeostasis; Host Defense; Image; Inflammatory; Integrins; International; Italy; Knowledge; Learning; Leukocyte Trafficking; Life; Malignant Neoplasms; Mediating; Modeling; Molecular; Myocardial Infarction; Neoplasm Metastasis; Participant; Pathogenesis; Physiologic Neovascularization; Play; Postdoctoral Fellow; Proliferating; Reperfusion Injury; Request for Applications; Research; Research Personnel; Resort; Role; Scientist; Signal Transduction; Site; Solid Neoplasm; Stroke; Structure; Students; Suspension substance; Suspensions; Systems Development; Therapeutic; Thrombosis; Thrombus; Time; Tissues; Training; Translating; Tumor Angiogenesis; Vascular blood supply; Vascular remodeling; Wound Healing; abstracting; adhesion receptor; cancer therapy; cell motility; data exchange; design; embryo tissue; experience; graduate student; human disease; in vivo; insight; malignant phenotype; meetings; member; migration; neoplastic cell; next generation; peer; posters; programs; symposium; tumor

DESCRIPTION (provided by applicant): We request partial support for the Fibronectin, Integrins and Related Molecules Gordon Research Conference and Gordon Research Seminar. The meetings will be held on April 30 - May 6, 2011 in the Il Ciocco Hotel and Resort, Lucca (Barga), Italy. The broad and long-term objectives of the conference are to increase our understanding of the fundamental molecular mechanisms of cell adhesion; to provide insights into how integrin-mediated adhesion contributes to normal embryonic development and tissue homeostasis; and to discover how it impacts human diseases such as cancer and cardiovascular disease. The meeting also plays an important role in educating and training the next generation of scientists and in recognition of this, for the first time, the conference will be preceded by a two-day Gordon-Kenan Research Seminar (GRS), designed to provide a unique forum for graduate students, post-docs, and other scientists with comparable levels of experience and education, to discuss their current research, learn from one another, network with their peers, and interact with select leading scientists from the associated Gordon Research Conference. The GRS also serves to prepare students to make a full and active contribution to the main conference which follows immediately after the symposium ends. The specific aims of this application are to convene at least 30 invited speakers, representing the cutting edge of current research in the area, and a total of approximately 170 participants for a five-day conference along with 50 postdoc or student participants in the GRS. The meeting will be held in a relatively isolated setting to maximize opportunities for informal interactions between delegates. The program will have sessions devoted to integrin structure, activation and signaling; the assembly and dynamics of multi-molecular adhesion sites; the roles of integrins in cell migration, mechano-sensing and mechano-signaling, cytoskeletal dynamics, and the assembly and remodeling of the extracellular matrix. A further session will focus on integrins in in vivo and disease models. The GRS will include a keynote address and sessions on live imaging and modeling of integrin adhesion site dynamics and new components and network interactions in the integrin adhesome. In addition to the invited speakers both the GRC and GRS programs will contain short talks selected from submitted abstracts and there will be posters sessions to further maximize scientific discussions. The Gordon Research Conference on Fibronectin, Integrins and Related Molecules is the pre-eminent gathering of integrin researchers and because it is held only every second year it is eagerly anticipated and usually heavily over-subscribed. It will now include the two-day Gordon-Kenan Research Seminar, prior to the conference, to maximize its role in training the next generation of scientists. For these reasons it provides a vital opportunity for the members of this dynamic field to exchange information and ideas, and to develop new directions, including those of direct relevance to treating human disease. PUBLIC HEALTH RELEVANCE: Partial support is sought for an international conference on Fibronectin, Integrins and Related Molecules. Integrin function is perturbed in a variety of diseases, notably cancer and inflammatory and cardiovascular diseases and we anticipate that this meeting of experts and trainees will stimulate discussions and exchanges of ideas that will provide new insights into the roles of integrins in disease pathogenesis, and possible treatments.

描述（由申请人提供）：我们要求对纤连蛋白，整合素和相关分子戈登研究会议和戈登研究研讨会要求部分支持。会议将于2011年4月30日至2011年5月6日在意大利的卢卡（Barga）的IL Ciocco Hotel and Resort举行。会议的广泛和长期目标是增加我们对细胞粘附基本分子机制的理解。提供有关整联蛋白介导的粘附如何有助于正常胚胎发育和组织稳态的见解；并发现它如何影响癌症和心血管疾病等人类疾病。这次会议还在教育和培训下一代科学家方面也起着重要作用，并为此对此进行认可，首次将在为期两天的戈登 - 肯南研究研讨会（GRS）之前，旨在为研究生，博士学位和其他科学家与当前的经验和教育进行互动，并与他们的当前研究互动，并与他们的当前研究互动，并与他们的当前研究互动，并与他们的当前研究互动，并与他们的当前研究员进行互动，并与他们的当前研究员进行互动，并与他们的当前研究员进行互动，并为他们提供了一项独特的论坛。研究会议。 GRS还为学生做好准备，为主要会议做出充分而积极的贡献，该会议紧接在研讨会结束后立即进行。本申请的具体目的是召集至少30名受邀演讲者，代表该地区当前研究的最前沿，共有约170名参与者参加为期五天的会议，以及50名Postdoc或GRS的学生参与者。会议将在相对孤立的环境中举行，以最大程度地利用代表之间非正式互动的机会。该程序将举办专门用于整合素结构，激活和信号传导的会议；多分子粘附位点的组装和动力学；整联蛋白在细胞迁移，机械感应和机械信号，细胞骨架动力学以及细胞外基质的组装和重塑中的作用。进一步的会议将重点介绍体内和疾病模型中的整合素。 GRS将包括有关实时成像的主题演讲和会议，并在整合素蛋白aDHOSON中进行整合素粘附站点动力学和新组件以及网络相互作用。除了受邀演讲者外，GRC和GRS计划都将包含从提交摘要中选择的简短演讲，并将举行海报会议，以进一步最大化科学讨论。戈登纤连蛋白，整联蛋白和相关分子的研究会议是整合素研究人员的杰出聚会，因为它仅每隔第二年就被举行，因此人们热切期待并且通常会超重订阅。现在，它将在会议之前包括为期两天的戈登 - 肯南研究研讨会，以最大程度地发挥其在培训下一代科学家中的作用。由于这些原因，它为这个动态领域的成员提供了一个至关重要的机会来交换信息和思想，并开发了新的方向，包括与治疗人类疾病的直接相关的方向。 公共卫生相关性：寻求纤连蛋白，整合素和相关分子国际会议的部分支持。整联蛋白功能在多种疾病中受到干扰，尤其是癌症，炎症性和心血管疾病，我们预计专家和受训者的这次会议将刺激讨论和交流思想的交流，这些思想将提供有关整合素在疾病病原体中的作用的新见解，以及可能的治疗方法。