ASM Conference on Viral Genome Replication

ASM 病毒基因组复制会议

• 批准号: 8129412
• 负责人: Sean PJ Whelan
• 金额: $ 1万
• 依托单位: AMERICAN SOCIETY FOR MICROBIOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-03-01 至 2012-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8129412
• 关键词: Academia; Accounting; Acute; Affect; Alberta province; American; Antiviral Agents; Antiviral Therapy; Biochemical; Biological; Canada; Cessation of life; Chronic; Clinical; Communicable Diseases; DNA; DNA Viruses; DNA-Directed DNA Polymerase; DNA-Directed RNA Polymerase; Data; Development; Discipline; Disease; Disease Outcome; Elements; Environment; Enzymes; Feedback; Fostering; Funding; Goals; Government; HIV; Health; Hepatitis C virus; Human; Human poliovirus; Industry; Infection; Infection prevention; Intervention; Knowledge; Link; Measles; Microbiology; Molecular; Morbidity - disease rate; Oral; Pathogenesis; Polioviruses; Process; Publications; RNA; RNA Viruses; Rabies; Research; Research Personnel; Rinderpest; Scientist; Simplexvirus; Smallpox; Societies; Technology; Therapeutic; Time; Translations; Vaccination; Vaccines; Viral; Viral Genome; Viral Vaccines; Virus; Virus Diseases; Work; abstracting; base; career; design; enzyme structure; insight; interdisciplinary approach; interest; meetings; mortality; resistance mechanism; single molecule; symposium; unpublished works; viral RNA; virology

DESCRIPTION (provided by applicant): Viral infections account for the majority of infectious disease deaths worldwide. Viral vaccines have proved effective in controlling many diseases and have resulted in the global eradication of smallpox. Rinderpest, will shortly be the second infection eradicated by vaccination and this will hopefully be followed by measles and poliovirus. Despite this, there are numerous chronic viral infections - HIV, HCV and HSV as well as acute viral infections - RSV, Rabies, for which vaccines either do not exist or are not widely distributed. Antiviral intervention has resulted in improvement of disease outcome for HIV and HSV, as well as for RSV. The development of effective vaccines and antiviral agents by rational design demands a detailed molecular and biochemical understanding of the replication cycle of the causative agents and how this is linked to pathogenesis of disease. Such an undertaking can only be accomplished through the cooperation of scientists from multiple disciplines working in government, academic and industrial settings. Funds are requested to provide partial support for a new American Society of Microbiology conference on Viral Genome Replication, which will be held from February 6-9, 2011 in Banff, Alberta. This conference will bring together researchers working at the forefront of the mechanism of viral genome replication from all classes of viruses. It has been the tradition in virology to divide and conquer and there is an acute need for a different paradigm: to unify and conquer. The division of virology into DNA vs. RNA, positive-strand RNA vs. negative-strand RNA, herpes vs. pox, picornas vs. hepaci has led to a circumstance in which the lexicon for one virus is virtually unintelligible to an investigator studying another virus. As a result, both intellectual and technical advances made with one virus that could apply to another can go virtually unnoticed. This circumstance is particularly problematic in the field of viral genome replication where, for example, mechanistic insight obtained for a viral replicative DNA polymerase could apply to a viral replicative RNA polymerase but connections are not made because of the historical divide that exists between DNA and RNA virologists. The (re)establishment of a meeting that will bring investigators together based on their common interest in a step of the viral lifecycle rather than the virus type will reinvigorate a field that is key to our ability to treat and prevent and viral infections. We also particularly desire to cross pollinate among researchers working on the strategies of replication at the single molecule, structural, and biochemical level with chemists working on strategies of intervention reflecting the three themes of the meeting: (i) Viral genome replication strategies; (ii) Elements, factors and enzymes: Structure, function and mechanism; (iii) Antivirals: Targets, mechanisms and resistance. PUBLIC HEALTH RELEVANCE: Viral infections account for the majority of morbidity and mortality associated with infectious disease worldwide. Knowledge gained from studies of viral genome replication has already facilitated the development of effective vaccines and antiviral therapies against some of these agents. The ASM sponsored conference entitled "Viral Genome Replication" is dedicated to exploring the state-of-the-art in this critical field. The aims of this conference are to bring together researchers from academia, government and industry probing the mechanisms of viral genome replication irrespective of the type of virus and foster an environment in which ideas and information are freely exchanged.

描述（由申请人提供）：病毒感染占全世界大多数传染病死亡。事实证明，病毒疫苗可有效控制许多疾病，并导致了全球天花的根除。 Rinderpest将很快成为通过疫苗消除的第二种感染，希望随后是麻疹和脊髓灰质炎病毒。尽管如此，仍有许多慢性病毒感染 - HIV，HCV和HSV以及急性病毒感染 - RSV，狂犬病，疫苗不存在或不存在广泛分布。抗病毒干预导致艾滋病毒和HSV以及RSV的疾病预后改善。通过合理设计的有效疫苗和抗病毒药物的开发需要对病原体的复制周期的详细分子和生化理解，以及如何将其与疾病的发病机理联系起来。只有通过在政府，学术和工业环境中工作的多个学科的科学家的合作才能完成这样的事业。要求资金为新的美国微生物学会大会会议提供部分支持，该学会将于2011年2月6日至9日在艾伯塔省班夫举行。这次会议将汇集到所有类别病毒的病毒基因组复制机制的最前沿的研究人员。划分和征服一直是病毒学中的传统，对不同的范式迫切需要：统一和征服。病毒学分为DNA与RNA，阳性RNA与负链RNA，疱疹与Pox，Picornas vs. Hepaci的划分导致了一种情况，其中一种病毒的词典对于研究另一种病毒的研究者几乎无法理解。结果，一种可以适用于另一种病毒的病毒所取得的智力和技术进步几乎没有引起人们的注意。在病毒基因组复制领域，这种情况尤其有问题，例如，对于病毒复制性DNA聚合酶获得的机械洞察力可能适用于病毒复制RNA聚合酶，但由于DNA病毒学家和RNA病毒学家之间存在的历史鸿沟而没有建立联系。 （重新）建立一场会议，该会议将根据病毒生命周期的一步而不是病毒类​​型将调查人员汇集在一起​​，这将振兴一个领域，这是我们治疗和预防和预防和病毒感染能力的关键。我们还尤其渴望在从事复制策略，结构和生化水平的研究人员之间进行授粉，并通过从事干预策略的化学家，反映了会议的三个主题：（i）病毒基因组复制策略； （ii）元素，因素和酶：结构，功能和机制； （iii）抗病毒药：目标，机制和耐药性。 公共卫生相关性：病毒感染解释了与全球传染病相关的大多数发病率和死亡率。从病毒基因组复制的研究中获得的知识已经促进了针对其中一些药物的有效疫苗和抗病毒疗法的开发。 ASM赞助的题为“病毒基因组复制”的会议致力于探索这个关键领域的最先进。这次会议的目的是将来自学术界，政府和行业的研究人员汇集在一起​​，探讨病毒基因组复制机制，而与病毒类型无关，并促进了一个自由交流思想和信息的环境。