HPV Vaccination in the Cambodian Community

简介（由申请人提供）：子宫颈癌是本港发病及死亡的主要原因。几乎所有的宫颈癌都是由HPV感染引起的。几种HPV疫苗（可以预防70%的宫颈癌）已经被批准用于美国女孩和年轻女性。大多数柬埔寨裔美国人是作为移民来到美国的，超过一半的人英语水平有限。东南亚裔妇女的宫颈癌发病率高于其他任何种族/族裔群体，柬埔寨人的发病率是非西班牙裔白人的两倍（15.0比7.7 / 100,000）。该研究的目标是开展混合方法研究，为针对9-17岁年龄段有女儿的柬埔寨妇女制定、实施和评估文化上适当的HPV疫苗接种干预措施提供信息。应同时使用定性和定量方法来检查东南亚和其他移民群体预防性保健做法的决定因素。我们的主要目标是：提供与促进柬埔寨社区使用HPV疫苗有关的定性数据；柬埔寨青少年接种HPV疫苗的定量数据，以及HPV疫苗接种的相关因素。最近对美国HPV疫苗监测的回顾发现，没有出版物涉及自我报告的HPV疫苗摄取的可靠性。我们的第二个目标是评估柬埔寨研究组中人乳头瘤病毒疫苗摄取调查措施的测试-再测试可靠性。我们以社区为基础的参与性研究将以与柬埔寨社区的长期合作为基础。现有的柬埔寨社区联盟将担任该项目的社区咨询委员会。有9-17岁女儿且居住在西雅图-塔科马大都市区的柬埔寨妇女将被纳入本研究。我们的研究将使用健康行为框架的理论视角。定性和定量研究阶段将依次进行。我们将完成对柬埔寨母亲的25次定性访谈。定性数据调查结果将用于指导定量调查工具的发展。将对200名柬埔寨母亲进行以社区为基础的电话调查，并要求50名调查参与者的子样本完成重新测试调查。

DESCRIPTION (provided by applicant): Cervical cancer is a major cause of morbidity and mortality. Virtually all cancers of the cervix are caused by HPV infection. Several HPV vaccines (that could prevent 70 percent of all cervical cancers) have been approved for American girls and young women. The majority of Cambodian Americans came to the US as immigrants and over one-half have limited English proficiency. Women of Southeast Asian descent have higher cervical cancer incidence rates than any other racial/ethnic group, and the incidence among Cambodians is twice the incidence among non-Hispanic whites (15.0 versus 7.7 per 100,000). The study goal is to conduct mixed-methods research that could be used to inform the development, implementation, and evaluation of culturally appropriate HPV vaccination interventions targeting Cambodian women with daughters in the 9-17 age group. Qualitative and quantitative methods should both be used to examine determinants of preventive health practices in Southeast Asian and other immigrant groups. Our primary objectives are: to provide qualitative data relevant to the promotion of HPV vaccine use in Cambodian communities; and quantitative data about the uptake of HPV vaccination among Cambodian adolescents, as well as correlates of HPV vaccine uptake. A recent review of HPV vaccine surveillance in the US found no publications addressing the reliability of self-reported HPV vaccine uptake. Our secondary objective is to assess the test-retest reliability of survey measures addressing HPV vaccine uptake in a Cambodian study group. Our community-based participatory research will build on a long-standing collaboration with the Cambodian community. An existing Cambodian Community Coalition will serve as the community advisory board for the project. Cambodian women who have a daughter in the 9-17 age group and live in the Seattle-Tacoma metropolitan area will be included in this study. Our research will use the theoretical perspective of the Health Behavior Framework. Qualitative and quantitative study phases will be conducted sequentially. We will complete 25 qualitative interviews with Cambodian mothers. Qualitative data findings will be used to guide the development of a quantitative survey instrument. A community-based telephone survey of 200 Cambodian mothers will be conducted, and a sub-sample of 50 survey participants will be asked to complete a retest survey. PUBLIC HEALTH RELEVANCE: This project will provide valuable qualitative and quantitative information about HPV vaccination in the Cambodian community. Project findings could be used to guide the development, implementation, and evaluation of culturally appropriate HPV vaccination educational materials and intervention programs for Cambodian Americans.