HPV Vaccination in the Cambodian Community

描述(申请人提供)：宫颈癌是发病率和死亡率的主要原因。几乎所有的宫颈癌都是由HPV感染引起的。几种HPV疫苗(可以预防70%的宫颈癌)已经被批准用于美国女孩和年轻女性。大多数柬埔寨裔美国人是以移民身份来到美国的，超过一半的人英语水平有限。东南亚裔妇女的宫颈癌发病率比其他任何种族/民族都高，柬埔寨人的发病率是非西班牙裔白人的两倍(15.0比7.7/10万)。这项研究的目标是进行混合方法研究，这些研究可用于为针对9-17岁有女儿的柬埔寨妇女制定、实施和评估文化上适当的HPV疫苗接种干预措施提供信息。应同时使用定性和定量方法来检查东南亚和其他移民群体的预防性卫生做法的决定因素。我们的主要目标是：提供与在柬埔寨社区推广使用HPV疫苗相关的定性数据；以及关于柬埔寨青少年接受HPV疫苗接种的定量数据，以及HPV疫苗接种的相关性。最近对美国HPV疫苗监测的一项审查发现，没有任何出版物涉及自我报告的HPV疫苗接种的可靠性。我们的次要目标是评估柬埔寨研究小组中针对HPV疫苗接种情况的调查措施的重测可靠性。我们以社区为基础的参与性研究将建立在与柬埔寨社区长期合作的基础上。现有的柬埔寨社区联盟将作为该项目的社区咨询委员会。居住在西雅图-塔科马大都市区、女儿年龄在9-17岁之间的柬埔寨女性将被纳入这项研究。我们的研究将使用健康行为框架的理论视角。定性和定量研究阶段将按顺序进行。我们将完成对柬埔寨母亲的25次定性采访。将使用定性数据结果来指导定量调查工具的开发。将对200名柬埔寨母亲进行社区电话调查，并要求50名调查参与者完成重测调查。 公共卫生相关性：该项目将提供有关柬埔寨社区接种HPV疫苗的有价值的定性和定量信息。项目结果可以用来指导为柬埔寨裔美国人编写、实施和评估符合文化背景的HPV疫苗接种教育材料和干预计划。

DESCRIPTION (provided by applicant): Cervical cancer is a major cause of morbidity and mortality. Virtually all cancers of the cervix are caused by HPV infection. Several HPV vaccines (that could prevent 70 percent of all cervical cancers) have been approved for American girls and young women. The majority of Cambodian Americans came to the US as immigrants and over one-half have limited English proficiency. Women of Southeast Asian descent have higher cervical cancer incidence rates than any other racial/ethnic group, and the incidence among Cambodians is twice the incidence among non-Hispanic whites (15.0 versus 7.7 per 100,000). The study goal is to conduct mixed-methods research that could be used to inform the development, implementation, and evaluation of culturally appropriate HPV vaccination interventions targeting Cambodian women with daughters in the 9-17 age group. Qualitative and quantitative methods should both be used to examine determinants of preventive health practices in Southeast Asian and other immigrant groups. Our primary objectives are: to provide qualitative data relevant to the promotion of HPV vaccine use in Cambodian communities; and quantitative data about the uptake of HPV vaccination among Cambodian adolescents, as well as correlates of HPV vaccine uptake. A recent review of HPV vaccine surveillance in the US found no publications addressing the reliability of self-reported HPV vaccine uptake. Our secondary objective is to assess the test-retest reliability of survey measures addressing HPV vaccine uptake in a Cambodian study group. Our community-based participatory research will build on a long-standing collaboration with the Cambodian community. An existing Cambodian Community Coalition will serve as the community advisory board for the project. Cambodian women who have a daughter in the 9-17 age group and live in the Seattle-Tacoma metropolitan area will be included in this study. Our research will use the theoretical perspective of the Health Behavior Framework. Qualitative and quantitative study phases will be conducted sequentially. We will complete 25 qualitative interviews with Cambodian mothers. Qualitative data findings will be used to guide the development of a quantitative survey instrument. A community-based telephone survey of 200 Cambodian mothers will be conducted, and a sub-sample of 50 survey participants will be asked to complete a retest survey. PUBLIC HEALTH RELEVANCE: This project will provide valuable qualitative and quantitative information about HPV vaccination in the Cambodian community. Project findings could be used to guide the development, implementation, and evaluation of culturally appropriate HPV vaccination educational materials and intervention programs for Cambodian Americans.