Insights on Glaucoma from Analysis of the CIGTS Data

CIGTS 数据分析对青光眼的见解

• 批准号: 8111469
• 负责人: DAVID C MUSCH
• 金额: $ 23.33万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8111469
• 关键词: Address; African; Aftercare; Age; Applications Grants; Characteristics; Clinical Trials; Comorbidity; Data; Data Analyses; Development; Diabetes Mellitus; Diagnosis; Event; Eye; Family; Future; Glaucoma; Incidence; Intervention; Linear Regressions; Location; Medical; Methods; Monitor; Morphologic artifacts; National Eye Institute; Natural History; Newly Diagnosed; Open-Angle Glaucoma; Operative Surgical Procedures; Outcome; Patient Care Management; Patients; Physiologic Intraocular Pressure; Probability; Race; Recording of previous events; Reporting; Research; Resources; Risk Factors; Role; Scotoma; Time; Variant; Vision; Visual Fields; base; clinically relevant; cost effective; evidence base; insight; predictive modeling; response

DESCRIPTION (provided by applicant): The Collaborative Initial Glaucoma Treatment Study (CIGTS), a National Eye Institute supported multicenter clinical trial, provided unique insights to how newly diagnosed open-angle glaucoma (OAG) should be treated, whether by initial surgical or medical intervention. Even so, much clinically-relevant and important information to glaucoma and its treatment remains to be evaluated in the extensive CIGTS data resource. Conduct of the proposed data analyses described in this grant application will provide unique, cost-effective opportunities to investigate additional research questions that are directly relevant to the management and care of patients who have open-angle glaucoma. We propose to conduct extensive analyses that address the following four specific aims: (1) Develop a predictive model that provides a ranking of factors that influence improvement in visual field (VF) during treatment of OAG. (2) Describe the natural history of open-angle glaucoma (OAG) development in initially un-treated fellow eyes, and develop a predictive model for the onset of OAG in such eyes. (3) Investigate VF defects documented in the CIGTS, including their location, cluster number, and extent at baseline, response to IOP reduction and elevation, and the association of baseline VF defect characteristics with the probability of progressive VF loss. (4) Compare alternate methods to define and analyze progressive loss of visual field - pointwise linear regression, mixed linear regression, "event-based" methods, and trajectory analysis - with regard to the outcomes they yield (risk factors, estimates of VF progression). PUBLIC HEALTH RELEVANCE: The Collaborative Initial Glaucoma Treatment Study, a National Eye Institute supported multicenter clinical trial, provided unique insights to how newly diagnosed glaucoma should be treated, whether by initial surgical or medical intervention. Conduct of the proposed data analyses described in this grant application will expand our ability to provide evidence-based direction to the management and care of patients diagnosed with glaucoma. In addition, these analyses will inform future studies of how best to evaluate progression of visual field loss in glaucoma, which is the most important outcome to monitor in studies of glaucoma treatment.

描述(由申请人提供)：协作性初始青光眼治疗研究(CIGTS)是一项由国家眼科研究所支持的多中心临床试验，为新诊断的开角型青光眼(OAG)应该如何治疗提供了独特的见解，无论是通过初始手术还是药物干预。尽管如此，许多与青光眼及其治疗有关的临床相关和重要信息仍有待在广泛的CIGTS数据资源中进行评估。本拨款申请中所述的拟议数据分析的实施将提供独特的、具有成本效益的机会，以调查与开角型青光眼患者的管理和护理直接相关的其他研究问题。我们建议进行广泛的分析，以解决以下四个具体目标：(1)开发一个预测模型，提供影响OAG治疗期间视野(VF)改善的因素的排名。(2)描述未经治疗的对侧眼发生开角型青光眼(OAG)的自然历史，并建立OAG发病的预测模型。(3)调查CIGTS中记录的室颤缺陷，包括它们的位置、簇数、基线时的范围、对眼压降低和升高的反应，以及基线室颤缺陷特征与进行性室颤丧失的可能性的关系。(4)比较定义和分析进行性视野丧失的其他方法--逐点线性回归、混合线性回归、“基于事件”的方法和轨迹分析--它们产生的结果(危险因素、VF进展的估计)。 公共卫生相关性：协作性初始青光眼治疗研究是由国家眼科研究所支持的多中心临床试验，为新诊断的青光眼应该如何治疗提供了独特的见解，无论是通过初始手术还是通过药物干预。本拨款申请中所述的拟议数据分析的实施将扩大我们为被诊断为青光眼的患者的管理和护理提供循证指导的能力。此外，这些分析将为未来的研究提供信息，如何最好地评估青光眼视野丧失的进展，这是青光眼治疗研究中需要监测的最重要的结果。