Bariatric Surgery, Gastric Stimulation: Metabolic Effects

减肥手术、胃刺激:代谢效应

基本信息

  • 批准号:
    8004335
  • 负责人:
  • 金额:
    $ 10.01万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2010
  • 资助国家:
    美国
  • 起止时间:
    2010-01-20 至 2010-12-31
  • 项目状态:
    已结题

项目摘要

DESCRIPTION (provided by applicant): The long-term objectives of this proposal are to examine hormonal mechanisms that may regulate weight loss and weight maintenance induced by bariatric surgery and implantable gastric stimulation (IGS). Particular focus is on hormones of the gut-central nervous system axis that are involved in appetite regulation, gut motility, energy partitioning and energy ZV expenditure. The objectives of Aim One are: a) to compare the changes in both fasting and post-prandial concentrations of ghrelin (total and octanoylated) and peptide YY (PYY) before and after Roux-en-Y gastric bypass (GBP) and gastric banding (BND) in a long-term prospective study and determine if these changes correlate with hunger, satiety, degree of weight loss weight maintenance; b) to characterize and; the fasting and post-prandial concentrations using high performance liquid chromatography of the two molecular forms of PYY, PYY(l-36) and PYY(3-36), in relation to body weight and weight reduction after GBP and BND; and c) to determine if there are differences in plasma leptin per unit fat mass and body composition, particularly visceral fat mass, using nuclear magnetic resonance imaging in weight-reduced individuals after GBP and BND procedures. Aim Two compares metabolic and neuroendocrine changes in individuals GBP and END. The purposes of this who have lost an equivalent amount of weight by calorie restriction, Aim are: a) to determine the role of the foregut in mediating insulin sensitivity through the use of intravenous glucose tolerance tests with frequent blood sampling; and b) compare the effects on thyroid and growth hormone axes with these three weight loss modalities. The focus of Aim Three is to elucidate possible hormonal mechanisms for weight loss induced by the IGS system, a new modality of weight loss therapy currently under investigation. The ultimate goal is to use information from these studies for the development of obesity treatments that are less invasive than bariatric surgery and more effective than current pharmacotherapy.
描述(由申请人提供):这项提案的长期目标是研究可能调节减肥手术和植入性胃刺激(IGS)诱导的体重减轻和体重维持的激素机制。特别关注的是肠道-中枢神经系统轴的激素,这些激素参与食欲调节、肠道运动、能量分配和能量ZV消耗。目标一的目标是:a)在一项长期的前瞻性研究中,比较Roux-en-Y胃旁路手术(GBP)和胃束带手术(BND)前后Ghrelin(总的和辛酰化的)和多肽YY(PYY)的空腹和餐后浓度的变化,并确定这些变化是否与饥饿、饱腹感、减肥维持程度有关;b)利用高效液相色谱法测定PYY(L-36)和PYY(3-36)两种分子形式的空腹和餐后浓度,与GBP和BND后体重和体重减轻的关系;以及c)使用核磁共振成像,确定在GBP和BND手术后,体重减轻的个体的每单位脂肪质量和身体成分,特别是内脏脂肪质量的血浆瘦素是否存在差异。目的比较GBP和END个体代谢和神经内分泌的变化。这项研究的目的是:a)通过使用静脉葡萄糖耐量试验和频繁采血来确定前肠在调节胰岛素敏感性中的作用;以及b)比较这三种减肥方式对甲状腺和生长激素轴的影响。目标三的重点是阐明IGS系统诱导减肥的可能激素机制,IGS系统是目前正在研究的一种新的减肥疗法。最终目标是利用这些研究的信息来开发比减肥手术侵入性更小、比目前的药物疗法更有效的肥胖治疗方法。

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

Judith Korner其他文献

Judith Korner的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('Judith Korner', 18)}}的其他基金

Association of genetic variation near the dopamine D2 receptor gene and other polymorphisms that modulate dopaminergic and opioid signaling on the weight loss response to naltrexone/bupropion
多巴胺 D2 受体基因附近的遗传变异与调节多巴胺能和阿片类信号传导对纳曲酮/安非他酮减肥反应的其他多态性的关联
  • 批准号:
    10586181
  • 财政年份:
    2023
  • 资助金额:
    $ 10.01万
  • 项目类别:
Changes in CSF Biomarkers after Bariatric Surgery
减肥手术后脑脊液生物标志物的变化
  • 批准号:
    10672445
  • 财政年份:
    2020
  • 资助金额:
    $ 10.01万
  • 项目类别:
Changes in CSF Biomarkers after Bariatric Surgery
减肥手术后脑脊液生物标志物的变化
  • 批准号:
    10460460
  • 财政年份:
    2020
  • 资助金额:
    $ 10.01万
  • 项目类别:
Changes in CSF Biomarkers after Bariatric Surgery
减肥手术后脑脊液生物标志物的变化
  • 批准号:
    10217130
  • 财政年份:
    2020
  • 资助金额:
    $ 10.01万
  • 项目类别:
Effects of Leptin on Body Weight and Neuroendocrine Axes after Gastric Bypass
瘦素对胃绕道手术后体重和神经内分泌轴的影响
  • 批准号:
    7447685
  • 财政年份:
    2008
  • 资助金额:
    $ 10.01万
  • 项目类别:
Effects of Leptin on Body Weight and Neuroendocrine Axes after Gastric Bypass
瘦素对胃绕道手术后体重和神经内分泌轴的影响
  • 批准号:
    7583938
  • 财政年份:
    2008
  • 资助金额:
    $ 10.01万
  • 项目类别:
Bariatric Surgery, Gastric Stimulation: Metabolic Effects
减肥手术、胃刺激:代谢效应
  • 批准号:
    7107942
  • 财政年份:
    2005
  • 资助金额:
    $ 10.01万
  • 项目类别:
Metabolic and Endocrine Effects of Bariatric Surgery
减肥手术的代谢和内分泌影响
  • 批准号:
    8457096
  • 财政年份:
    2005
  • 资助金额:
    $ 10.01万
  • 项目类别:
Metabolic and Endocrine Effects of Bariatric Surgery
减肥手术的代谢和内分泌影响
  • 批准号:
    9403777
  • 财政年份:
    2005
  • 资助金额:
    $ 10.01万
  • 项目类别:
Metabolic and Endocrine Effects of Bariatric Surgery
减肥手术的代谢和内分泌影响
  • 批准号:
    8850432
  • 财政年份:
    2005
  • 资助金额:
    $ 10.01万
  • 项目类别:

相似海外基金

How Does Particle Material Properties Insoluble and Partially Soluble Affect Sensory Perception Of Fat based Products
不溶性和部分可溶的颗粒材料特性如何影响脂肪基产品的感官知觉
  • 批准号:
    BB/Z514391/1
  • 财政年份:
    2024
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Training Grant
BRC-BIO: Establishing Astrangia poculata as a study system to understand how multi-partner symbiotic interactions affect pathogen response in cnidarians
BRC-BIO:建立 Astrangia poculata 作为研究系统,以了解多伙伴共生相互作用如何影响刺胞动物的病原体反应
  • 批准号:
    2312555
  • 财政年份:
    2024
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Standard Grant
RII Track-4:NSF: From the Ground Up to the Air Above Coastal Dunes: How Groundwater and Evaporation Affect the Mechanism of Wind Erosion
RII Track-4:NSF:从地面到沿海沙丘上方的空气:地下水和蒸发如何影响风蚀机制
  • 批准号:
    2327346
  • 财政年份:
    2024
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Standard Grant
Graduating in Austerity: Do Welfare Cuts Affect the Career Path of University Students?
紧缩毕业:福利削减会影响大学生的职业道路吗?
  • 批准号:
    ES/Z502595/1
  • 财政年份:
    2024
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Fellowship
感性個人差指標 Affect-X の構築とビスポークAIサービスの基盤確立
建立个人敏感度指数 Affect-X 并为定制人工智能服务奠定基础
  • 批准号:
    23K24936
  • 财政年份:
    2024
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Grant-in-Aid for Scientific Research (B)
Insecure lives and the policy disconnect: How multiple insecurities affect Levelling Up and what joined-up policy can do to help
不安全的生活和政策脱节:多种不安全因素如何影响升级以及联合政策可以提供哪些帮助
  • 批准号:
    ES/Z000149/1
  • 财政年份:
    2024
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Research Grant
How does metal binding affect the function of proteins targeted by a devastating pathogen of cereal crops?
金属结合如何影响谷类作物毁灭性病原体靶向的蛋白质的功能?
  • 批准号:
    2901648
  • 财政年份:
    2024
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Studentship
Investigating how double-negative T cells affect anti-leukemic and GvHD-inducing activities of conventional T cells
研究双阴性 T 细胞如何影响传统 T 细胞的抗白血病和 GvHD 诱导活性
  • 批准号:
    488039
  • 财政年份:
    2023
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Operating Grants
New Tendencies of French Film Theory: Representation, Body, Affect
法国电影理论新动向:再现、身体、情感
  • 批准号:
    23K00129
  • 财政年份:
    2023
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
The Protruding Void: Mystical Affect in Samuel Beckett's Prose
突出的虚空:塞缪尔·贝克特散文中的神秘影响
  • 批准号:
    2883985
  • 财政年份:
    2023
  • 资助金额:
    $ 10.01万
  • 项目类别:
    Studentship
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了